Case study on iron in mental development - in memory of John Beard (1947-2009)

Nutrition Reviews

Volumn 68, Issue SUPPL. 1, 2010, Pages

  Osendarp, Saskia J M ^a,b   Murray Kolb, Laura E ^c   Black, Maureen M ^d  

^a UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Brain development; Child development; Iron

Indexed keywords

IRON;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN DEVELOPMENT; BRAIN REGION; CHILD; CHILD DEVELOPMENT; HUMAN; IRON DEFICIENCY ANEMIA; MENTAL DEVELOPMENT; NONHUMAN;

ANEMIA, IRON-DEFICIENCY; BRAIN; CHILD; CHILD NUTRITIONAL PHYSIOLOGICAL PHENOMENA; CHILD, PRESCHOOL; COGNITION; COGNITION DISORDERS; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; IRON, DIETARY; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RISK FACTORS;

EID: 77958458711     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2010.00331.x     Document Type: Article

References (43)

1. World Health Organisation. Worldwide Prevalence of Anaemia 1993-2005: WHO Global Database on Anaemia. De Benoist B, McLean E, Egli I, Cogswell M, eds. Geneva, Switzerland: WHO Press; 2008.
2. McLean E, Egli I, De Benoist B, Wojdyla D, Cogswell M. Worldwide prevalence of anemia in pre-school aged children, pregnant women and non-pregnant women of reproductive age. In: Kraemer K, Zimmermann MB, eds. Nutritional Anemia. Basel, Switzerland: Sight and Life Press; 2007:1-12.
3. Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr. 2001;131(Suppl):S616-633.
4. Haas JD, Brownlie IV. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr. 2001;131(Suppl):S676-690.
5. Sachdev HPS, Gera T, Nestel P. Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials. Public Health Nutr. 2006;9:904-920.
6. Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105:E51.
7. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64(Suppl):S34-43.
8. Stoltzfus RJ, Kvalsvig JD, Chwaya HM, et al. Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. BMJ. 2001;323:1389-1393.
9. Beard J. Recent evidence from human and animal studies regarding iron status and infant development. J Nutr. 2007;137(Suppl):S524-530.
10. Black MM, Lozoff B. Nutrition and child development. In: Haith MM, Benson JB, eds. Encyclopedia of Infant and Child Development. Oxford, UK: Elsevier Inc.; 2008:449-459.
11. Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol. 2006;13:158-165.
12. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131(Suppl):S649-666.
13. Lozoff B, Jimenez E, Smith JB. Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years. Arch Pediatr Adolesc Med. 2006;160:1108-1113.
14. Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(Suppl):S560-571.
15. Sachdev HPS, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr. 2005;8:117-132.
16. Lynn R, Harland EP. A positive effect of iron supplementation on the IQs of iron deficient children. Pers Individ Dif. 1998;24:883-885.
17. Seshadri S, Gopaldas T. Impact of iron supplementation on cognitive functions in preschool and school-aged children - the Indian experience. Am J Clin Nutr. 1989;50:675-686.
18. Beard J. Iron deficiency alters brain development and functioning. J Nutr. 2003;133(Suppl):S1468-S1472.
19. Taylor EM, Crowe A, Morgan EH. Transferrin and iron uptake by the brain: effects of altered iron status. J Neurochem. 1991;57:1584-1592.
20. Crowe A, Morgan EH. Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res. 1992;592:8-16.
21. Han J, Day JR, Connor JR, Beard JL. Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Nutr Neurosci. 2003;6:1-10.
22. Rao R, Tkac I, Townsend EL, Gruetter R, Georgieff MK. Perinatal iron deficiency alters the neurochemical profile of the developing rat hippocampus. J Nutr. 2003;133:3215-3221.
23. Beard JL. Why iron deficiency is important in infant development. J Nutr. 2008;138:2534-2536.
24. Beard JL, Wiesinger JA, Connor JR. Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats. Dev Neurosci. 2003;25:308-315.
25. Bianco LE, Wiesinger J, Earley CJ, Jones BC, Beard JL. Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley rats. J Neurochem. 2008;106:205-215.
26. Burhans MS, Dailey C, Beard Z, et al. Iron deficiency: differential effects on monoamine transporters. Nutr Neurosci. 2005;8:31-38.
27. Burhans MS, Dailey C, Wiesinger J, Murray-Kolb LE, Jones BC, Beard JL. Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats. Physiol Behav. 2006;87:917-924.
28. Dwork AJ, Lawler G, Zybert PA, et al. An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res. 1990;518:31-39.
29. Aoki S, Okada Y, Nishimura K, et al. Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T. Radiology. 1989;172:381-385.
30. Beard JL, Connor JD, Jones BC. Brain iron: location and function. Prog Food Nutr Sci. 1993;17:183-221.
31. Beard JL, Unger EL, Bianco LE, Paul T, Rundle SE, Jones BC. Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats. J Nutr. 2007;137:1176-1182.
32. Felt BT, Lozoff B. Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development. J Nutr. 1996;126:693-701.
33. Roncagliolo M, Garrido M, Walter T, Peirano P, Lozoff B. Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses. Am J Clin Nutr. 1998;68:683-690.
34. Burden MJ, Westerlund AJ, Armony-Sivan R, et al. An event-related potential study of attention and recognition memory in infants with iron-deficiency anemia. Pediatrics. 2007;120:e336-e345.
35. Lozoff B, Clark KM, Jing Y, Armony-Sivan R, Angelilli ML, Jacobson SW. Dose-response relationships between iron deficiency with or without anemia and infant social-emotional behavior. J Pediatr. 2008;152:696-702.
36. Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007;369:60-70.
37. Black RE, Allen LH, Bhutta ZA, et al. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet. 2008;371:243-260.
38. Copenhagen Business School. Global Crises, Global Solutions: Costs and Benefits. Cambridge: Cambridge University Press; 2009.
39. Horton S, Alderman H. The economics of addressing nutritional anemia. In: Kraemer K, Zimmermann MB, eds. Nutritional Anemia. Zurich: Sight and Life Press; 2007:19-35.
40. Beard JL, Connor JR, Jones BC. Iron in the brain. Nutr Rev. 1993;51:157-170.
41. Beard JL, Hendricks MK, Perez EM, et al. Maternal iron deficiency anemia affects postpartum emotions and cognition. J Nutr. 2005;135:267-272.
42. Perez EM, Hendricks MK, Beard JL, et al. Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. J Nutr. 2005;135:850-855.
43. Murray-Kolb LE, Beard JL. Iron deficiency and child and maternal health. Am J Clin Nutr. 2009;89(Suppl):S946-S950.