Coexistence of myeloma cast nephropathy, light chain deposition disease, and nonamyloid fibrils in a patient with multiple myeloma

American Journal of Kidney Diseases

Volumn 56, Issue 5, 2010, Pages 971-976

  Qian, Qi ^a   Leung, Nelson ^a   Theis, Jason D ^a   Dogan, Ahmet ^a   Sethi, Sanjeev ^a  

^a MAYO CLINIC   (United States)

Author keywords

cast nephropathy; Heavy and light chain deposition disease; Index Words; laser microdissection; mass spectrometry; multiple myeloma; proteomics

Indexed keywords

ALBUMIN; AMYLOID P COMPONENT; CALCITONIN; CALCIUM; DEXAMETHASONE; HEMOGLOBIN; IMMUNOGLOBULIN; ISOTONIC SOLUTION; LENALIDOMIDE; PAMIDRONIC ACID; IMMUNOGLOBULIN LIGHT CHAIN;

ACUTE KIDNEY FAILURE; ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CALCIUM BLOOD LEVEL; CASE REPORT; CONFUSION; CYTOGENETICS; DIZZINESS; GLOMERULAR NONAMYLOID FIBRILLARY DEPOSITION; GLOMERULOPATHY; HEAVY CHAIN DISEASE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; KIDNEY DISEASE; LASER MICRODISSECTION; LIGHT CHAIN DEPOSITION; LIGHT CHAIN DEPOSITION DISEASE; MALE; MASS SPECTROMETRY; MENTAL DEFICIENCY; MULTIPLE MYELOMA; MYELOMA; MYELOMA CAST NEPHROPATHY; PARAPROTEINEMIA; PROTEOMICS; RIB FRACTURE; THROMBOCYTE COUNT; UREA NITROGEN BLOOD LEVEL; WEAKNESS; BIOPSY; COMPLICATION; DIFFERENTIAL DIAGNOSIS; ELECTRON MICROSCOPY; FLUORESCENCE MICROSCOPY; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW UP; GLOMERULUS; IMMUNOLOGY; KIDNEY TUBULE; MIDDLE AGED; PATHOLOGY; ULTRASTRUCTURE;

BIOPSY; DIAGNOSIS, DIFFERENTIAL; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW-UP STUDIES; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES; MALE; MASS SPECTROMETRY; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MULTIPLE MYELOMA;

EID: 77958454213     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2010.06.018     Document Type: Article

References (12)

1. S. Sethi, M. Hanna, and F. Fervenza Unusual casts in a case of multiple myeloma Am J Kidney Dis 54 2009 970 974
2. E.C. Lorenz, S. Sethi, and T.L. Poshusta Renal failure due to combined cast nephropathy, amyloidosis and light-chain deposition disease Nephrol Dial Transplant 25 2010 1340 1343
3. J. Lin, G.S. Markowitz, and A.M. Valeri Renal monoclonal immunoglobulin deposition disease: the disease spectrum J Am Soc Nephrol 12 2001 1482 1492
4. N. Gokden, N. Cetin, and N. Colakoglu Morphologic manifestations of combined light-chain deposition disease and light-chain cast nephropathy Ultrastruct Pathol 31 2007 141 149
5. J.A. Vrana, J.D. Gamez, B.J. Madden, J.D. Theis, H.R. Bergen III, and A. Dogan Classification of amyloidosis by laser microdissection and mass spectrometry-based proteomic analysis in clinical biopsy specimens Blood 114 2009 4957 4959
6. F.J. Rodriguez, J.D. Gamez, and J.A. Vrana Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues Lab Invest 88 2008 1024 1037
7. D.V. Miller, A. Dogan, and S. Sethi New-onset proteinuria with massive amorphous glomerular deposits Am J Kidney Dis 55 2010 749 754
8. C.E. Alpers, and J. Kowalewska Fibrillary glomerulonephritis and immunotactoid glomerulopathy J Am Soc Nephrol 19 2008 34 37
9. S.M. Korbet, M.M. Schwartz, and E.J. Lewis Immunotactoid glomerulopathy (fibrillary glomerulonephritis) Clin J Am Soc Nephrol 1 2006 1351 1356
10. L.M. Dember Light chains, casts, sheets and fibrils: monoclonal immunoglobulin diseases and immunotactoid/fibrillary glomerulopathy Clin J Am Soc Nephrol 1 2006 1320 1321
11. J.R. Sedor Tissue proteomics: a new investigative tool for renal biopsy analysis Kidney Int 75 2009 876 879
12. S. Sethi, J.D. Gamez, and J.A. Vrana Glomeruli of dense deposit disease contain components of the alternative and terminal complement pathway Kidney Int 75 2009 952 960