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Volumn 172, Issue 3, 2010, Pages 305-310

Crystal structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa

Author keywords

Antibiotic resistance; Gene regulation; MexZ; Pseudomonas aeruginosa; TetR

Indexed keywords

BACTERIAL PROTEIN; MEXZ PROTEIN; TETR PROTEIN; UNCLASSIFIED DRUG;

EID: 77958185365     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2010.07.012     Document Type: Article
Times cited : (26)

References (38)
  • 2
    • 0345466364 scopus 로고    scopus 로고
    • Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides
    • Aires J.R., Kohler T., Nikaido H., Plesiat P. Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrob. Agents Chemother. 1999, 43(11):2624-2628.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , Issue.11 , pp. 2624-2628
    • Aires, J.R.1    Kohler, T.2    Nikaido, H.3    Plesiat, P.4
  • 3
    • 34248152648 scopus 로고    scopus 로고
    • Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials
    • Alguel Y., Meng C., Teran W., Krell T., Ramos J.L., Gallegos M.T., Zhang X. Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials. J. Mol. Biol. 2007, 369(3):829-840.
    • (2007) J. Mol. Biol. , vol.369 , Issue.3 , pp. 829-840
    • Alguel, Y.1    Meng, C.2    Teran, W.3    Krell, T.4    Ramos, J.L.5    Gallegos, M.T.6    Zhang, X.7
  • 5
    • 13244281317 scopus 로고    scopus 로고
    • Coot: model-building tools for molecular graphics
    • Pt.1
    • Emsley P., Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 2004, 60(Pt. 12, Pt.1):2126-2132.
    • (2004) Acta Crystallogr. D Biol. Crystallogr. , vol.60 , Issue.PART. 12 , pp. 2126-2132
    • Emsley, P.1    Cowtan, K.2
  • 6
    • 0034075360 scopus 로고    scopus 로고
    • Antimicrobial susceptibility and frequency of occurrence of clinical blood isolates in Europe from the SENTRY antimicrobial surveillance program, 1997 and 1998
    • Fluit A.C., Jones M.E., Schmitz F.J., Acar J., Gupta R., Verhoef J. Antimicrobial susceptibility and frequency of occurrence of clinical blood isolates in Europe from the SENTRY antimicrobial surveillance program, 1997 and 1998. Clin. Infect. Dis. 2000, 30(3):454-460.
    • (2000) Clin. Infect. Dis. , vol.30 , Issue.3 , pp. 454-460
    • Fluit, A.C.1    Jones, M.E.2    Schmitz, F.J.3    Acar, J.4    Gupta, R.5    Verhoef, J.6
  • 7
    • 77958166373 scopus 로고    scopus 로고
    • Annual Report. Cystic Fibrosis Foundation, Bethesda.
    • Foundation CF, 2002. Annual Report. Cystic Fibrosis Foundation, Bethesda.
    • (2002)
    • Foundation, C.F.1
  • 8
    • 0037397798 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa pneumonia
    • Garau J., Gomez L. Pseudomonas aeruginosa pneumonia. Curr. Opin. Infect. Dis. 2003, 16(2):135-143.
    • (2003) Curr. Opin. Infect. Dis. , vol.16 , Issue.2 , pp. 135-143
    • Garau, J.1    Gomez, L.2
  • 9
    • 0035214060 scopus 로고    scopus 로고
    • Distribution and prevalence of antimicrobial resistance among gram-negative isolates in intensive care units (ICU) in Belgian hospitals between 1996 and 1999
    • Glupczynski Y., Delmee M., Goossens H., Struelens M. Distribution and prevalence of antimicrobial resistance among gram-negative isolates in intensive care units (ICU) in Belgian hospitals between 1996 and 1999. Acta Clin. Belg. 2001, 56(5):297-306.
    • (2001) Acta Clin. Belg. , vol.56 , Issue.5 , pp. 297-306
    • Glupczynski, Y.1    Delmee, M.2    Goossens, H.3    Struelens, M.4
  • 10
    • 34248658815 scopus 로고    scopus 로고
    • Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection
    • Govan J.R., Brown A.R., Jones A.M. Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol. 2007, 2:153-164.
    • (2007) Future Microbiol. , vol.2 , pp. 153-164
    • Govan, J.R.1    Brown, A.R.2    Jones, A.M.3
  • 11
    • 0029814366 scopus 로고    scopus 로고
    • Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
    • Govan J.R., Deretic V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev. 1996, 60(3):539-574.
    • (1996) Microbiol. Rev. , vol.60 , Issue.3 , pp. 539-574
    • Govan, J.R.1    Deretic, V.2
  • 12
    • 0033826385 scopus 로고    scopus 로고
    • Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment
    • Hancock R.E., Speert D.P. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment. Drug Resist. Updat. 2000, 3(4):247-255.
    • (2000) Drug Resist. Updat. , vol.3 , Issue.4 , pp. 247-255
    • Hancock, R.E.1    Speert, D.P.2
  • 13
    • 0025262173 scopus 로고
    • Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure
    • Hendrickson W.A., Horton J.R., LeMaster D.M. Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three-dimensional structure. EMBO J. 1990, 9(5):1665-1672.
    • (1990) EMBO J. , vol.9 , Issue.5 , pp. 1665-1672
    • Hendrickson, W.A.1    Horton, J.R.2    LeMaster, D.M.3
  • 14
    • 0028244325 scopus 로고
    • Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance
    • Hinrichs W., Kisker C., Duvel M., Muller A., Tovar K., Hillen W., Saenger W. Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance. Science 1994, 264(5157):418-420.
    • (1994) Science , vol.264 , Issue.5157 , pp. 418-420
    • Hinrichs, W.1    Kisker, C.2    Duvel, M.3    Muller, A.4    Tovar, K.5    Hillen, W.6    Saenger, W.7
  • 15
    • 22544461608 scopus 로고    scopus 로고
    • Induction of the MexXY efflux pump in Pseudomonas aeruginosa is dependent on drug-ribosome interaction
    • Jeannot K., Sobel M.L., El Garch F., Poole K., Plesiat P. Induction of the MexXY efflux pump in Pseudomonas aeruginosa is dependent on drug-ribosome interaction. J. Bacteriol. 2005, 187(15):5341-5346.
    • (2005) J. Bacteriol. , vol.187 , Issue.15 , pp. 5341-5346
    • Jeannot, K.1    Sobel, M.L.2    El Garch, F.3    Poole, K.4    Plesiat, P.5
  • 16
    • 84889120137 scopus 로고
    • Kjeldgaard Improved methods for building protein models in electron density maps and the location of errors in these models
    • Jones T.A., Zou J.Y., Cowan S.W., Kjeldgaard Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 1991, 47(2):110-119.
    • (1991) Acta Crystallogr. A , vol.47 , Issue.2 , pp. 110-119
    • Jones, T.A.1    Zou, J.Y.2    Cowan, S.W.3
  • 17
    • 0027879008 scopus 로고
    • Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
    • Kabsch W. Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants. J. Appl. Cryst. 1993, 26:6.
    • (1993) J. Appl. Cryst. , vol.26 , pp. 6
    • Kabsch, W.1
  • 18
    • 0032695922 scopus 로고    scopus 로고
    • Bacterial antibiotic efflux systems of medical importance
    • Kohler T., Pechere J.C., Plesiat P. Bacterial antibiotic efflux systems of medical importance. Cell Mol. Life Sci. 1999, 56(9-10):771-778.
    • (1999) Cell Mol. Life Sci. , vol.56 , Issue.9-10 , pp. 771-778
    • Kohler, T.1    Pechere, J.C.2    Plesiat, P.3
  • 19
    • 0034031728 scopus 로고    scopus 로고
    • Aminoglycoside-resistance mechanisms for cystic fibrosis Pseudomonas aeruginosa isolates are unchanged by long-term, intermittent, inhaled tobramycin treatment
    • MacLeod D.L., Nelson L.E., Shawar R.M., Lin B.B., Lockwood L.G., Dirk J.E., Miller G.H., Burns J.L., Garber R.L. Aminoglycoside-resistance mechanisms for cystic fibrosis Pseudomonas aeruginosa isolates are unchanged by long-term, intermittent, inhaled tobramycin treatment. J. Infect. Dis. 2000, 181(3):1180-1184.
    • (2000) J. Infect. Dis. , vol.181 , Issue.3 , pp. 1180-1184
    • MacLeod, D.L.1    Nelson, L.E.2    Shawar, R.M.3    Lin, B.B.4    Lockwood, L.G.5    Dirk, J.E.6    Miller, G.H.7    Burns, J.L.8    Garber, R.L.9
  • 20
    • 4444337691 scopus 로고    scopus 로고
    • MexZ-mediated regulation of mexXY multidrug efflux pump expression in Pseudomonas aeruginosa by binding on the mexZ-mexX intergenic DNA
    • Matsuo Y., Eda S., Gotoh N., Yoshihara E., Nakae T. MexZ-mediated regulation of mexXY multidrug efflux pump expression in Pseudomonas aeruginosa by binding on the mexZ-mexX intergenic DNA. FEMS Microbiol. Lett. 2004, 238(1):23-28.
    • (2004) FEMS Microbiol. Lett. , vol.238 , Issue.1 , pp. 23-28
    • Matsuo, Y.1    Eda, S.2    Gotoh, N.3    Yoshihara, E.4    Nakae, T.5
  • 21
    • 33644746633 scopus 로고    scopus 로고
    • Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product
    • Morita Y., Sobel M.L., Poole K. Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product. J. Bacteriol. 2006, 188(5):1847-1855.
    • (2006) J. Bacteriol. , vol.188 , Issue.5 , pp. 1847-1855
    • Morita, Y.1    Sobel, M.L.2    Poole, K.3
  • 22
    • 0022462584 scopus 로고
    • Prevalence and mechanisms of aminoglycoside resistance. A ten-year study
    • Phillips I., King A., Shannon K. Prevalence and mechanisms of aminoglycoside resistance. A ten-year study. Am. J. Med. 1986, 80(6B):48-55.
    • (1986) Am. J. Med. , vol.80 , Issue.6 B , pp. 48-55
    • Phillips, I.1    King, A.2    Shannon, K.3
  • 23
    • 1642422948 scopus 로고    scopus 로고
    • Efflux-mediated multiresistance in Gram-negative bacteria
    • Poole K. Efflux-mediated multiresistance in Gram-negative bacteria. Clin. Microbiol. Infect. 2004, 10(1):12-26.
    • (2004) Clin. Microbiol. Infect. , vol.10 , Issue.1 , pp. 12-26
    • Poole, K.1
  • 24
    • 12944262276 scopus 로고    scopus 로고
    • Aminoglycoside resistance in Pseudomonas aeruginosa
    • Poole K. Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 2005, 49(2):479-487.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , Issue.2 , pp. 479-487
    • Poole, K.1
  • 25
    • 0035353081 scopus 로고    scopus 로고
    • Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance
    • Poole K., Srikumar R. Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance. Curr. Top. Med. Chem. 2001, 1(1):59-71.
    • (2001) Curr. Top. Med. Chem. , vol.1 , Issue.1 , pp. 59-71
    • Poole, K.1    Srikumar, R.2
  • 29
    • 0346694551 scopus 로고    scopus 로고
    • Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions
    • Schweizer H.P. Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions. Genet. Mol. Res. 2003, 2(1):48-62.
    • (2003) Genet. Mol. Res. , vol.2 , Issue.1 , pp. 48-62
    • Schweizer, H.P.1
  • 31
    • 33646364338 scopus 로고    scopus 로고
    • Effector-repressor interactions, binding of a single effector molecule to the operator-bound TtgR homodimer mediates derepression
    • Teran W., Krell T., Ramos J.L., Gallegos M.T. Effector-repressor interactions, binding of a single effector molecule to the operator-bound TtgR homodimer mediates derepression. J. Biol. Chem. 2006, 281(11):7102-7109.
    • (2006) J. Biol. Chem. , vol.281 , Issue.11 , pp. 7102-7109
    • Teran, W.1    Krell, T.2    Ramos, J.L.3    Gallegos, M.T.4
  • 33
    • 0031729127 scopus 로고    scopus 로고
    • Cell-to-cell signaling and Pseudomonas aeruginosa infections
    • Van Delden C., Iglewski B.H. Cell-to-cell signaling and Pseudomonas aeruginosa infections. Emerg. Infect. Dis. 1998, 4(4):551-560.
    • (1998) Emerg. Infect. Dis. , vol.4 , Issue.4 , pp. 551-560
    • Van Delden, C.1    Iglewski, B.H.2
  • 34
    • 0034030439 scopus 로고    scopus 로고
    • Microbial resistance: lessons from the EPIC study. European Prevalence of Infection
    • Vincent J.L. Microbial resistance: lessons from the EPIC study. European Prevalence of Infection. Intensive Care Med. 2000, 26(Suppl. 1):S3-S8.
    • (2000) Intensive Care Med. , vol.26 , Issue.SUPPL. 1
    • Vincent, J.L.1
  • 35
    • 0029148091 scopus 로고
    • The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee
    • Vincent J.L., Bihari D.J., Suter P.M., Bruining H.A., White J., Nicolas-Chanoin M.H., Wolff M., Spencer R.C., Hemmer M. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA 1995, 274(8):639-644.
    • (1995) JAMA , vol.274 , Issue.8 , pp. 639-644
    • Vincent, J.L.1    Bihari, D.J.2    Suter, P.M.3    Bruining, H.A.4    White, J.5    Nicolas-Chanoin, M.H.6    Wolff, M.7    Spencer, R.C.8    Hemmer, M.9
  • 36
    • 2142697190 scopus 로고    scopus 로고
    • Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Vogne C., Aires J.R., Bailly C., Hocquet D., Plesiat P. Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob. Agents Chemother. 2004, 48(5):1676-1680.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , Issue.5 , pp. 1676-1680
    • Vogne, C.1    Aires, J.R.2    Bailly, C.3    Hocquet, D.4    Plesiat, P.5
  • 38
    • 71049141260 scopus 로고    scopus 로고
    • Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa. Microbiology
    • Yamamoto, M., Ueda, A., Kudo, M., Matsuo, Y., Fukushima, J., Nakae, T., Kaneko, T., Ishigatsubo, Y., 2009. Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa. Microbiology.
    • (2009)
    • Yamamoto, M.1    Ueda, A.2    Kudo, M.3    Matsuo, Y.4    Fukushima, J.5    Nakae, T.6    Kaneko, T.7    Ishigatsubo, Y.8


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