Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: A 1-week randomized clinical trial in healthy young men

Diabetes Care

Volumn 33, Issue 8, 2010, Pages 1831-1833

  Lapauw, Bruno ^a   Ouwens, Margriet ^b   'T Hart, Leen M ^c   Wuyts, Birgitte ^a   Holst, Jens J ^d   T'Sjoen, Guy ^a   Kaufman, Jean Marc ^a   Ruige, Johannes B ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DERMESTRIL PLUS LETROZOLE; ESTRADIOL; GASTRIC INHIBITORY POLYPEPTIDE; LETROZOLE; TESTOSTERONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY COMPOSITION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GLUCOSE CLAMP TECHNIQUE; HUMAN; HUMAN EXPERIMENT; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL;

ADULT; AROMATASE INHIBITORS; ESTRADIOL; FASTING; GASTRIC INHIBITORY POLYPEPTIDE; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; MALE; NITRILES; POSTPRANDIAL PERIOD; TESTOSTERONE; TRIAZOLES; TRIGLYCERIDES; YOUNG ADULT;

EID: 77958156356     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-0515     Document Type: Article

References (15)

1. Haring R, Völzke H, Felix SB, Schipf S, Dörr M, Rosskopf D, Nauck M, Schöfl C, Wallaschofski H. Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania. Diabetes 2009;58:2027-2031
2. Khaw KT, Barrett-Connor E. Lower endogenous androgens predict central adiposity in men. Metabolism Ann Epidemiol 1992;2:675-682
3. Colangelo LA, Ouyang P, Liu K, Kopp P, Golden SH, Dobs AS, Szklo M, Vaidya D, Cushman M, Gapstur SM. Association of endogenous sex hormones with diabetes and impaired fasting glucose in men: multi-ethnic study of atherosclerosis. Diabetes Care 2009;32:1049-1051
4. Lapauw B, T'Sjoen G, Mahmoud A, Kaufman JM, Ruige JB. Short-term aromatase inhibition: effects on glucose metabolism and serum leptin levels in young and elderly men. Eur J Endocrinol 2009;160:397-402
5. Lin HJ, Lee BC, Ho YL, Lin YH, Chen CY, Hsu HC, Lin MS, Chien KL, Chen MF. Postprandial glucose improves the risk prediction of cardiovascular death beyond the metabolic syndrome in the nondiabetic population. Diabetes Care 2009;32:1721-1726
6. Ferrannini E, Mari A. How to measure insulin sensitivity. J Hypertens 1998;16:895-906
7. Deacon CF, Holst JJ. Immunoassays for the incretin hormones GIP and GLP-1. Best Pract Res Clin Endocrinol Metab 2009;23:425-432
8. o study. Nutr Metab Cardiovasc Dis 2008;18:256-262
9. Ruige JB, Van Gaal LF. Low fasting triglycerides: hallmark of the healthy large hip? Obesity (Silver Spring) 2009;17:1621-1626
10. Yialamas MA, Dwyer AA, Hanley E, Lee H, Pitteloud N, Hayes FJ. Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2007;92:4254-4259
11. Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, Defronzo RA, Cusi K. Dose-response effect of elevated plasma free fatty acid on insulin signaling. Diabetes 2005;54:1640-1648
12. Ukropcova B, McNeil M, Sereda O, de Jonge L, Xie H, Bray GA, Smith SR. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest 2005;115:1934-1941
13. Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterology 2007;133:1796-1805
14. Singh SK, Bartoo AC, Krishnan S, Boylan MO, Schwartz JH, Michael Wolfe M. Glucose-dependent insulinotropic polypeptide (GIP) stimulates transepithelial glucose transport. Obesity (Silver Spring) 2008;16:2412-2416
15. Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia 2002;45:1201-1210