Comparative study of coagulation and thrombin generation in the portal and jugular plasma of patients with cirrhosis

Thrombosis and Haemostasis

Volumn 104, Issue 4, 2010, Pages 741-749

  Delahousse, Bénédicte ^a   Labat Debelleix, Valérie ^a   Decalonne, Loic ^a   D'Alteroche, Louis ^a   Perarnau, Jean Marc ^a   Gruel, Yves ^a,b  

^a UNIVERSITY HOSPITAL OF TOURS   (France)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

Cirrhosis; Coagulation; Liver disease; Thrombin generation assay

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; BLOOD CLOTTING FACTOR 8; D DIMER; FIBRINOGEN; PHOSPHOLIPID; PROTEIN C; PROTEIN S; PROTHROMBIN; THROMBIN; THROMBOMODULIN; THROMBOPLASTIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CHILD PUGH SCORE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE MUTATION; HUMAN; HYPERCOAGULABILITY; JUGULAR VEIN; LIVER CIRRHOSIS; MALE; PARTIAL THROMBOPLASTIN TIME; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; SCORING SYSTEM; SCREENING TEST; TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT;

ADULT; AGED; BLOOD COAGULATION TESTS; FACTOR VIII; FEMALE; HUMANS; HYPERTENSION, PORTAL; JUGULAR VEINS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PORTAL VEIN; PORTASYSTEMIC SHUNT, TRANSJUGULAR INTRAHEPATIC; THROMBIN; THROMBOSIS;

EID: 77958140479     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-01-0040     Document Type: Article

References (35)

1. Boks AL, Brommer EJ, Schalm SW, et al. Hemostasis and fibrinolysis in severe liver failure and their relation to hemorrhage. Hepatology 1986; 6: 79-86.
2. Tripodi A, Mannucci PM. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. J Hepatol 2007; 46: 727-733. (Pubitemid 46400157)
3. Hemker HC, Giesen PL, Ramjee M, et al. The thrombogram: monitoring thrombin generation in platelet-rich plasma. Thromb Haemost 2000; 83: 589-591. (Pubitemid 30201136)
4. Hemker HC, Wielders S, Kessels H, et al. Continuous registration of thrombin generation in plasma, its use for the determination of the thrombin potential. Thromb Haemost 1993; 70: 617-624. (Pubitemid 23310567)
5. Baglin T. The measurement and application of thrombin generation. Br J Haematol 2005; 130: 653-661.
6. Tripodi A, Legnani C, Chantarangkul V, et al. High thrombin generation measured in the presence of thrombomodulin is associated with an increased risk of recurrent venous thromboembolism. J Thromb Haemost 2008; 6: 1327-1333. (Pubitemid 352016312)
7. Besser M, Baglin C, Luddington R, et al. High rate of unprovoked recurrent venous thrombosis is associated with high thrombin-generating potential in a prospective cohort study. J Thromb Haemost 2008; 6: 1720-1725.
8. Couturaud F, Duchemin J, Leroyer C, et al. Thrombin generation in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. A pilot study. Thromb Haemost 2008; 99: 223-228.
9. Segers O, van Oerle R, ten Cate H, et al. Thrombin generation as an intermediate phenotype for venous thrombosis. Thromb Haemost 2010; 103: 114-122.
10. Dargaud Y, Beguin S, Lienhart A, et al. Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. Thromb Haemost 2005; 93: 475-480. (Pubitemid 40392535)
11. Schols SE, van der Meijden PE, van Oerle R, et al. Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: relation to bleeding. Thromb Haemost 2008; 99: 64-70.
12. Salvagno GL, Astermark J, Lippi G, et al. Thrombin generation assay: a useful routine check-up tool in the management of patients with haemophilia? Haemophilia 2009; 15: 290-296.
13. Tripodi A, Salerno F, Chantarangkul V, et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology 2005; 41: 553-558. (Pubitemid 40289502)
14. Tripodi A, Primignani M, Chantarangkul V, et al. Thrombin generation in patients with cirrhosis: the role of platelets. Hepatology 2006; 44: 440-445. (Pubitemid 44214883)
15. Jacobi D, de Muret A, Arbeille B, et al. Transjugular intrahepatic portosystemic shunt for the treatment of portal hypertension secondary to non-cirrhotic perisinusoidal hepatic fibrosis. Eur J Gastroenterol Hepatol 2006; 18: 549-551. (Pubitemid 43832758)
16. Rossle M, Haag K, Ochs A, et al. The transjugular intrahepatic portosystemic stent-shunt procedure for variceal bleeding. N Engl J Med 1994; 330: 165-171. (Pubitemid 24026884)
17. Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-649.
18. Ripoll L, Paulin D, Thomas S, et al. Multiplex PCR-mediated site-directed mutagenesis for one-step determination of factor V Leiden and G20210A transition of the prothrombin gene. Thromb Haemost 1997; 78: 960-961.
19. Hemker HC, Giesen P, Al Dieri R, et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003; 33: 4-15. (Pubitemid 37449290)
20. Mayer LD, Hope MJ, Cullis PR. Vesicles of variable sizes produced by a rapid extrusion procedure. Biochim Biophys Acta 1986; 858: 161-168.
21. Dargaud Y, Trzeciak MC, Bordet JC, et al. Use of calibrated automated thrombinography +/- thrombomodulin to recognise the prothrombotic phenotype. Thromb Haemost. 2006; 96: 562-567. (Pubitemid 44782534)
22. Tchaikovski SN, van Vliet HA, Thomassen MC, et al. Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography. Thromb Haemost 2007; 98: 1350-1356.
23. Haidl H, Cimenti C, Leschnik B, et al. Age-dependency of thrombin generation measured by means of calibrated automated thrombography (CAT). Thromb Haemost 2006; 95: 772-775.
24. Dielis AW, Castoldi E, Spronk HM, et al. Coagulation factors and the protein C system as determinants of thrombin generation in a normal population. J Thromb Haemost 2008; 6: 125-131.
25. Al Dieri R, Peyvandi F, Santagostino E, et al. The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding. Thromb Haemost 2002; 88: 576-582. (Pubitemid 35173997)
26. Duchemin J, Pan-Petesch B, Arnaud B, et al. Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma. Thromb Haemost 2008; 99: 767-773. (Pubitemid 351694233)
27. Hollestelle MJ, Geertzen HG, Straatsburg IH, et al. Factor VIII expression in liver disease. Thromb Haemost 2004; 91: 267-275.
28. Martinelli I, Primignani M, Aghemo A, et al. High levels of factor VIII and risk of extra-hepatic portal vein obstruction. J Hepatol 2009; 50: 916-922.
29. Machlus KR, Colby EA, Wu JR, et al. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost 2009; 102: 936-944.
30. Tripodi A, Primignani M, Chantarangkul V, et al. An imbalance of pro- vs anticoagulation factors in plasma from patients with cirrhosis. Gastroenterology 2009; 137: 2105-2111.
31. Reverdiau-Moalic P, Delahousse B, Body G, et al. Evolution of blood coagulation activators and inhibitors in the healthy human fetus. Blood. 1996; 88: 900-906. (Pubitemid 26333312)
32. Zocco MA, Di Stasio E, De Cristofaro R, et al. Thrombotic risk factors in patients with liver cirrhosis: correlation with MELD scoring system and portal vein thrombosis development. J Hepatol 2009; 51: 682-689.
33. Fimognari FL, Violi F. Portal vein thrombosis in liver cirrhosis. Intern Emerg Med 2008; 3: 213-218.
34. Violi F, Ferro D, Basili S, et al. Ongoing prothrombotic state in the portal circulation of cirrhotic patients. Thromb Haemost 1997; 77: 44-47. (Pubitemid 27064966)
35. Hemker HC, Al Dieri R, De Smedt E, et al. Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 2006; 96: 553-561. (Pubitemid 44782533)