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Volumn 36, Issue 7, 2010, Pages 440-444

Whole-genome association studies for multigenic diseases: Ethical dilemmas arising from commercializationd the case of genetic testing for autism

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EID: 77958106087     PISSN: 03066800     EISSN: 14734257     Source Type: Journal    
DOI: 10.1136/jme.2009.031385     Document Type: Article
Times cited : (23)

References (26)
  • 1
    • 65949104586 scopus 로고    scopus 로고
    • Genomewide association studies and human disease
    • Hardy J, Singleton A. Genomewide association studies and human disease. N Engl J Med 2009;360:1759-68.
    • (2009) N Engl J Med , vol.360 , pp. 1759-1768
    • Hardy, J.1    Singleton, A.2
  • 2
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: consensus, uncertainty and challenges
    • McCarthy MI, Abecasis GR, Cardon LR, et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008;9:356-69.
    • (2008) Nat Rev Genet , vol.9 , pp. 356-369
    • McCarthy, M.I.1    Abecasis, G.R.2    Cardon, L.R.3
  • 3
    • 34147186908 scopus 로고    scopus 로고
    • Understanding autism: parents and pediatricians in historical perspective
    • Silverman C, Brosco JP. Understanding autism: parents and pediatricians in historical perspective. Arch Pediatr Adolesc Med 2007;161:392- 8.
    • (2007) Arch Pediatr Adolesc Med , vol.161 , pp. 392-398
    • Silverman, C.1    Brosco, J.P.2
  • 4
    • 0000984981 scopus 로고
    • Autistic disturbances of affective contact
    • Kanner L. Autistic disturbances of affective contact. Nervous Child 1943;2:217-50.
    • (1943) Nervous Child , vol.2 , pp. 217-250
    • Kanner, L.1
  • 6
    • 0017138765 scopus 로고
    • The genetics, if any, of infantile autism and childhood schizophrenia
    • Hanson DR, Gottesman II. The genetics, if any, of infantile autism and childhood schizophrenia. J Autism Child Schizophr 1976;6:209-34.
    • (1976) J Autism Child Schizophr , vol.6 , pp. 209-234
    • Hanson, D.R.1    Gottesman, I.I.2
  • 7
    • 0028906338 scopus 로고
    • Autism as a strongly genetic disorder: evidence from a British twin study
    • Bailey A, Le Couteur A, Gottesman I, et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 1995;25:63-77.
    • (1995) Psychol Med , vol.25 , pp. 63-77
    • Bailey, A.1    Le Couteur, A.2    Gottesman, I.3
  • 8
    • 33744462332 scopus 로고    scopus 로고
    • Genetics of autism spectrum disorder
    • Klauck SM. Genetics of autism spectrum disorder. Eur J Hum Genet 2006;14:714-20.
    • (2006) Eur J Hum Genet , vol.14 , pp. 714-720
    • Klauck, S.M.1
  • 9
    • 33847327313 scopus 로고    scopus 로고
    • Autism Genome Project, Consortium., Mapping autism risk loci using genetic linkage and chromosomal, rearrangements
    • Autism Genome Project Consortium. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet 2007;39:319-28.
    • (2007) Nat Genet , vol.39 , pp. 319-328
  • 10
    • 34247481814 scopus 로고    scopus 로고
    • Strong association of de novo copy number mutations with autism
    • Sebat J, Lakshmi B, Malhotra D, et al. Strong association of de novo copy number mutations with autism. Science 2007;316:445-9.
    • (2007) Science , vol.316 , pp. 445-449
    • Sebat, J.1    Lakshmi, B.2    Malhotra, D.3
  • 11
    • 42349095075 scopus 로고    scopus 로고
    • Advances in autism genetics: on the threshold of a new neurobiology
    • Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 2008;9:341-55.
    • (2008) Nat Rev Genet , vol.9 , pp. 341-355
    • Abrahams, B.S.1    Geschwind, D.H.2
  • 13
    • 77958113119 scopus 로고    scopus 로고
    • Wellcome Trust Centre for Human Genetics. Neurogenetics & Psychiatric Disorders Accessed 4 June 2010
    • Wellcome Trust Centre for Human Genetics. Neurogenetics & Psychiatric Disorders. http://www.well.ox.ac.uk/monaco/autism/autism_links.shtml (Accessed 4 June 2010).
  • 14
    • 27144517182 scopus 로고    scopus 로고
    • Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism
    • Philippi A, Roschmann E, Tores F, et al. Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism. Mol Psychiatry 2005;10:950-60.
    • (2005) Mol Psychiatry , vol.10 , pp. 950-960
    • Philippi, A.1    Roschmann, E.2    Tores, F.3
  • 15
    • 33845683734 scopus 로고    scopus 로고
    • Protein kinase C-beta 1 gene variants are not associated with autism in the Irish population
    • Yang MS, Cochrane L, Conroy J, et al. Protein kinase C-beta 1 gene variants are not associated with autism in the Irish population. Psychiatr Genet 2007;17:39-41.
    • (2007) Psychiatr Genet , vol.17 , pp. 39-41
    • Yang, M.S.1    Cochrane, L.2    Conroy, J.3
  • 16
    • 67649387094 scopus 로고    scopus 로고
    • Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression
    • Lintas C, Sacco R, Garbett K, et al. Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression. Mol Psychiatry 2009;14:705-18.
    • (2009) Mol Psychiatry , vol.14 , pp. 705-718
    • Lintas, C.1    Sacco, R.2    Garbett, K.3
  • 17
    • 38949210771 scopus 로고    scopus 로고
    • Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis
    • Philippi A, Tores F, Carayol J, et al. Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis. BMC Med Genet 2007;8:74.
    • (2007) BMC Med Genet , vol.8 , pp. 74
    • Philippi, A.1    Tores, F.2    Carayol, J.3
  • 18
    • 48349101819 scopus 로고    scopus 로고
    • Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism
    • Maussion G, Carayol J, Lepagnol-Bestel AM, et al. Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. Hum Mol Genet 2008;17:2541-51.
    • (2008) Hum Mol Genet , vol.17 , pp. 2541-2551
    • Maussion, G.1    Carayol, J.2    Lepagnol-Bestel, A.M.3
  • 19
    • 27144491428 scopus 로고    scopus 로고
    • Demandez le test de l'autisme! [Autism test on sale!]
    • Jordan B. Demandez le test de l'autisme! [Autism test on sale!]. Med Sci (Paris) 2005;21:886-7.
    • (2005) Med Sci (Paris) , vol.21 , pp. 886-887
    • Jordan, B.1
  • 20
    • 33847216876 scopus 로고    scopus 로고
    • L'autisme d'une entreprise [The autism of a company]
    • Jordan B. L'autisme d'une entreprise [The autism of a company]. Med Sci (Paris) 2007;23:215-16.
    • (2007) Med Sci (Paris) , vol.23 , pp. 215-216
    • Jordan, B.1
  • 21
    • 34249749922 scopus 로고    scopus 로고
    • Génétique et business: défendons la liberté de critique! [Genetics and business: in defence of free speech!]
    • Jordan B, Favre M, Barthelemy C, et al. Génétique et business: défendons la liberté de critique! [Genetics and business: in defence of free speech!]. Med Sci (Paris) 2007;23:545-6.
    • (2007) Med Sci (Paris) , vol.23 , pp. 545-546
    • Jordan, B.1    Favre, M.2    Barthelemy, C.3
  • 22
    • 77958097590 scopus 로고    scopus 로고
    • 23andMe Democratizes Personal Genetics Accessed 4 June 2010
    • 23andMe Democratizes Personal Genetics. https://www.23andme.com/about/press/20080909b/ (Accessed 4 June 2010).
  • 23
    • 50549102055 scopus 로고    scopus 로고
    • The contractual genome: how direct-to-consumer genomic services may help patients take ownership of their DNA
    • Accessed 4 June 2010
    • Foster MW, Sharp RR. The contractual genome: how direct-to-consumer genomic services may help patients take ownership of their DNA. Person Med 2008;5:399-404. http://www.futuremedicine.com/doi/full/10.2217/17410541.5.4.399 (Accessed 4 June 2010).
    • (2008) Person Med , vol.5 , pp. 399-404
    • Foster, M.W.1    Sharp, R.R.2
  • 24
    • 67650459886 scopus 로고    scopus 로고
    • Biomarkers in psychiatry
    • Singh l, Rose N. Biomarkers in psychiatry. Nature 2009;460:202-7.
    • (2009) Nature , vol.460 , pp. 202-207
    • Singh, l.1    Rose, N.2
  • 25
    • 35348957507 scopus 로고    scopus 로고
    • ASHG social issues committee ASHG statement on direct-to-consumer genetic testing in the United States
    • Hudson K, Javitt G, Burke W, et al. ASHG social issues committee. ASHG statement on direct-to-consumer genetic testing in the United States. Am J Hum Genet 2007;81:635-7.
    • (2007) Am J Hum Genet , vol.81 , pp. 635-637
    • Hudson, K.1    Javitt, G.2    Burke, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.