Hepatitis B therapy in pregnancy

Current Hepatitis Reports

Volumn 9, Issue 4, 2010, Pages 197-204

  Bzowej, Natalie H ^a  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

Antiviral; Hepatitis B; Lamivudine; Nucleoside; Nucleotide; Perinatal transmission; Pregnancy; Tenofovir; Treatment

Indexed keywords

ADEFOVIR; ALANINE AMINOTRANSFERASE; ENTECAVIR; HEPATITIS B ANTIBODY; HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; INTERFERON; LAMIVUDINE; PEGINTERFERON; PLACEBO; RNA DIRECTED DNA POLYMERASE INHIBITOR; TELBIVUDINE; TENOFOVIR; VIRUS DNA;

ANTIVIRAL RESISTANCE; BREAST FEEDING; CLINICAL TRIAL; CONGENITAL MALFORMATION; DELIVERY; DRUG EFFICACY; DRUG SAFETY; FIRST TRIMESTER PREGNANCY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOPROPHYLAXIS; INFECTION PREVENTION; MEDICAL DECISION MAKING; NONHUMAN; PREGNANCY; REVIEW; RISK BENEFIT ANALYSIS; SECOND TRIMESTER PREGNANCY; TERATOGENICITY; THIRD TRIMESTER PREGNANCY; TREATMENT DURATION; VERTICAL TRANSMISSION; VIRUS INHIBITION; VIRUS LOAD; VIRUS TRANSMISSION;

EID: 77958102964     PISSN: 15403416     EISSN: 15410706     Source Type: Journal    
DOI: 10.1007/s11901-010-0059-x     Document Type: Review

References (48)

1. World Health Organization: Hepatitis B: World Health Organization fact sheet 204 (revised August 2008). Available at http://www.who.int/mediacentre/ factsheets/fs204/en. Accessed August 2010.
2. GB Yao 1996 Importance of perinatal versus horizontal transmission of hepatitis B virus infection in China Gut 38 S39 S42 10.1136/gut.38.Suppl-2.S39 8786052
3. AS Lok BJ McMahon 2009 Chronic hepatitis B: update 2009 Hepatology 50 1 36
4. BJ McMahon WL Alward DB Hall, et al. 1985 Acute hepatitis B virus infection: relation to the clinical expression of disease and subsequent development of the carrier state J Infect Dis 151 599 603 1:STN:280: DyaL2M7jt12hsg%3D%3D 3973412
5. NC Tassopoulos GJ Papavangelou MH Sjogren, et al. 1987 Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults Gastroenterology 92 1844 1850 1:STN:280:DyaL2s7ptFKmsQ%3D%3D 3569758
6. MH Chang 2000 Natural history of hepatitis B virus infection in children J Gastroenterol Hepatol 15 Suppl E16 E19 10.1046/j.1440-1746.2000.02096.x 10921376 (Pubitemid 30435730)
7. EB Keeffe DT Dieterich SB Han, et al. 2008 A treatment algorithm for the management of chronic hepatitis B in the United States: 2008 update Clin Gastroenterol Hepatol 6 1315 1341 1:CAS:528:DC%2BD1MXhtFSlurk%3D 10.1016/j.cgh.2008.08.021 18845489
8. GK Lau T Piratvisuth KX Luo, et al. 2005 Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B N Engl J Med 352 2682 2695 1:CAS:528:DC%2BD2MXls1SktL8%3D 10.1056/NEJMoa043470 15987917 (Pubitemid 41007823)
9. Marcellin P, Heathcote EJ, Buti, M, et al.: Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. 2008, 359:2442-2455.
10. Antiretroviral Pregnancy Registry: Available at http://www.apregistry. com. Accessed August 2010.
11. RJ Fontana 2009 Side effects of long-term oral antiviral therapy for hepatitis B Hepatology 49 S185 S189 1:CAS:528:DC%2BD1MXlvFKqsb4%3D 10.1002/hep.22885 19399802
12. Munderi P, Wilkes H, Tumukunde D, et al.: Pregnancy and outcomes among women on triple-drug antiretroviral therapy (ART) in the DART trial [poster WEPEB261]. Presented at the Fifth IAS Conference on HIV Pathogenesis, Treatment and Prevention. Cape Town, South Africa; July 19-22, 2009.
13. FDA Pregnancy class definitions: Available at http://en.wikipedia.org/ wiki/Pregnancy-category. Accessed August 2010.
14. Berg T, Marcellin P, Zoulim F, et al.: Tenofovir is effective a monotherapy or in combination with emtricitabine in adefovir treated patients with chronic hepatitis B infection. Gastroenterology 2010 (Epub ahead of print).
15. CL Lai E Gane YF Liaw, et al. 2007 Telbivudine verus lamivudine in patients with chronic hepatitis B N Engl J Med 357 2576 2588 1:CAS:528:DC%2BD2sXhsVKht7nF 10.1056/NEJMoa066422 18094378 (Pubitemid 350294224)
16. G Nguyen RT Garcia N Nguyen, et al. 2009 Clinical course of hepatitis B virus infection during pregnancy Aliment Pharmacol Ther 29 755 764 1:STN:280:DC%2BD1M3gslansA%3D%3D 10.1111/j.1365-2036.2009.03932.x 19183158
17. RA de Man LM Wolters F Nevens, et al. 2001 Safety and efficacy of oral entecavir given for 28 days in patients with chronic hepatitis B virus infection Hepatology 34 578 582 10.1053/jhep.2001.26815 11526545 (Pubitemid 32786650)
18. T Santantonio M Mazzola T Iacovazzi, et al. 2000 Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine J Hepatol 32 300 306 1:CAS:528:DC%2BD3cXhtlyktrg%3D 10.1016/S0168-8278(00)80076-8 10707871 (Pubitemid 30093910)
19. SG Lim CT Wai A Rajnakova, et al. 2002 Fatal hepatitis B reactivation following discontinuation of nucleoside analogues for chronic hepatitis B Gut 51 597 599 1:STN:280:DC%2BD38vntlSmsg%3D%3D 10.1136/gut.51.4.597 12235087
20. RP Beasley LY Hwang CC Lin, et al. 1981 Hepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Initial report of a randomised double-blind placebo-controlled trial Lancet 2 388 393 1:STN:280:DyaL3M3mvFCmuw%3D%3D 6115159
21. RP Beasley LY Hwang CE Stevens 1983 Efficacy of hepatitis B immune globulin for prevention of perinatal transmission of the hepatitis B virus carrier state: final report of a randomized double-blind, placebo-controlled trial Hepatology 3 135 141 1:STN:280:DyaL3s7lvFWrsA%3D%3D 10.1002/hep.1840030201 6339349
22. RP Beasley LY Hwang GC Lee, et al. 1983 Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine Lancet 2 1099 1102 1:STN:280:DyaL2c%2FjvVGgsQ%3D%3D 10.1016/S0140-6736(83)90624-4 6138642
23. C Lee Y Gong J Brok, et al. 2006 Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis BMJ 332 328 336 10.1136/bmj.38719.435833.7C 16443611 (Pubitemid 43253746)
24. R del Canho PM Grosheide JA Mazel, et al. 1997 Ten-year neonatal hepatitis B vaccination program, The Netherlands, 1982-1992: protective efficacy and long-term immunogenicity Vaccine 15 1624 1630 10.1016/S0264-410X(97)00080-7 9364693 (Pubitemid 27445742)
25. E Wiseman MA Fraser S Holden, et al. 2009 Perinatal transmission of hepatitis B virus: an Australian experience Med J Aust 190 489 492 19413519 This study reported the perinatal transmission rate in 313 HBsAg-positive women from Australia. To date, most data have come from Asian countries. This study confirmed that immunoprophylaxis failure occurs in those with very high viral loads
26. L Mandelbrot A Landreau-Mascaro C Rekacewicz, et al. 2001 Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1 JAMA 285 2083 2093 1:CAS:528:DC%2BD3MXjs12ju78%3D 10.1001/jama.285.16. 2083 11311097
27. R Gupta T Warren A Wald 2007 Genital herpes Lancet 370 2127 2137 10.1016/S0140-6736(07)61908-4 18156035 (Pubitemid 350296304)
28. M van Zonneveld AB van Nunen HG Niesters, et al. 2003 Lamivudine treatment during pregnancy to prevent perinatal transmission of hepatitis B virus infection J Viral Hepat 10 294 297 10.1046/j.1365-2893.2003.00440.x 12823596 (Pubitemid 36801916)
29. WM Xu YT Cui L Wang, et al. 2009 Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, randomized, double-blind, placebo-controlled study J Viral Hepat 16 94 103 10.1111/j.1365-2893.2008.01056.x 19175878 This study is one that is unlikely to ever be performed again, because double-blind, placebo-controlled studies are difficult to do in pregnant women
30. Z Shi Y Yang L Ma, et al. 2010 Lamivudine in late pregnancy to interrupt in utero transmission of hepatitis B virus: a systematic review and meta-analysis Obstet Gynecol 116 147 159 10.1097/AOG.0b013e3181e45951 20567182 This meta-analysis helps to clarify whether antiviral therapy is beneficial in preventing perinatal transmission
31. XM Li YB Yang HY Hou, et al. 2003 Interruption of HBV intrauterine transmission: a clinical study World J Gastroenterol 9 1501 1503 1:CAS:528:DC%2BD3sXoslajtL8%3D 12854150
32. M Shi X Li J He, et al. 2005 Lamivudine in interruption of HBV intrauterine infection Clin Med Chin 21 77 78
33. ZH Han YH Chen LW Li, et al. 2005 Effect and safety of preventing HBV vertical transmission by lamivudine treatment Clin J Intern Med 44 378
34. WF Li R Jiang Z Wie Y Li 2006 Clinical effect and safety of lamivudine in interruption of chronic HBV maternal to infant transmission Chin Hepatol 11 106 107
35. HF Feng SF Zhang 2007 Effect on interruption of hepatitis B virus vertical transmission by lamivudine J Appl Clin Pediatr 22 1019 1020 1:CAS:528:DC%2BD1cXhsFKjur4%3D
36. GJ Xiang JW Sun SQ Jiang, et al. 2007 Evaluation of therapeutic effect in HBV vertical transmission by lamivudine treatment combined with active-passive immunization for pregnant women Clin Prac Med 2 14 16
37. JH Yang 2008 The clinical observation of effect of lamivudine on blocking mother to infant transmission of chronic HBV Int Med Health Guid News 14 76 78
38. S Yang M Liu L Wang 2008 Effect of high viral hepatitis B virus DANN loads on vertical transmission of hepatitis B virus in late-pregnant women Zhonghua Fu Chan Za Zhi 43 329 331 1:CAS:528:DC%2BD1cXptlKisr0%3D
39. Shi Z, Li X, Yang Y, Ma L: Clinical research on the interruption of mother to child transmission of HBV-a randomized, double-blind, placebo-controlled study. Presented at Unite for Sight 6th Annual Global Health Conference. New Haven, CT: Yale University; April 18-19, 2009.
40. SA Olivo LG Macedo IC Gadotti, et al. 2008 Scales to assess the quality of randomized controlled trials: a systematic review Phys Ther 88 156 175 10.2522/ptj.20070147 18073267 (Pubitemid 351210558)
41. LJ Zhang L Wang 2009 Blocking intrauterine infection by telbivudine in pregnant chronic hepatitis B patients [in Chinese] Zhonghua Gan Zang Bing Za Zhi 17 561 563 19719910
42. SN Kazim SM Wakil LA Khan, et al. 2002 Vertical transmission of hepatitis B virus despite maternal lamivudine therapy Lancet 359 1488 1489 10.1016/S0140-6736(02)08425-8 11988251 (Pubitemid 34457770)
43. DZ Xu YP Yan BC Choi, et al. 2002 Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case-control study J Med Virol 67 20 26 10.1002/jmv.2187 11920813 (Pubitemid 34260071)
44. MJ ter Borg WF Leemans RA de Man HL Janssen 2008 Exacerbation of chronic hepatitis B infection after delivery J Viral Hepat 15 37 41 18088243
45. Lamivudine [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2009. Available at http://us.gsk.com/products/assets/us-epivir.pdf. Accessed August 2010.
46. Tenofovir DF [package insert]. Foster City, CA: Gilead Sciences; 2010. Available at http://www.gilead.com/pdf/viread-pi.pdf. Accessed August 2010.
47. RP Beasley CE Stevens IS Shiao HC Meng 1975 Evidence against breast-feeding as a mechanism for vertical transmission of hepatitis B Lancet 2 740 741 1:STN:280:DyaE28%2FltVajtg%3D%3D 10.1016/S0140-6736(75)90724-2 52772
48. JB Hill JS Sheffield MJ Kim, et al. 2002 Risk of hepatitis b transmission in breast-fed infants of chronic hepatitis B carriers Obstet Gynecol 99 1049 1052 10.1016/S0029-7844(02)02000-8 12052598 (Pubitemid 34621230)