A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India

Maturitas

Volumn 67, Issue 3, 2010, Pages 239-244

  Singh, Monica ^a   Singh, Puneetpal ^a   Singh, Surinder ^b   Juneja, Pawan Kumar ^b   Kaur, Taranpal ^c  

^a PUNJABI UNIVERSITY   (India)

^b Aggarwal Orthopedic Hospital   (India)

^c Amrit Poly Clinic   (India)

Author keywords

APOE SNPs; BMD; Haplotypes; India; Osteoporosis; Postmenopausal females

Indexed keywords

APOLIPOPROTEIN E;

ARTICLE; BONE DENSITY; BONE MASS; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; INDIA; MAJOR CLINICAL STUDY; OSTEOPENIA; OSTEOPOROSIS; POSTMENOPAUSE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; APOLIPOPROTEINS E; BODY MASS INDEX; BONE DENSITY; COHORT STUDIES; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; INDIA; MIDDLE AGED; OBESITY; OSTEOPOROSIS, POSTMENOPAUSAL; POLYMORPHISM, GENETIC; PREMENOPAUSE; RISK FACTORS; WOMEN'S HEALTH;

EID: 77958101229     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2010.06.017     Document Type: Article

References (29)

1. World Health Organization (WHO) Consensus development conference, diagnosis, prophylaxis and treatment of osteoporosis Am J Med 94 1993 646 650
2. N.A. Pocock, J.A. Eisman, J.L. Hopper, M.G. Yeates, P.N. Sambrook, and S. Eberl Genetic determinants of bone mass in adults. A twin Study J Clin Invest 80 1987 706 710
3. R. Gueguen, P. Jouanny, F. Guillemin, C. Kuntz, J. Pourel, and G. Siest Segregation analysis and variance components analysis of bone mineral density in healthy families J Bone Miner Res 10 1995 2017 2022
4. W. Horst-Sikorska, R. Kalak, A. Wawrzyniak, M. Marcinkowska, L. Celczynska-Bajew, and R. Slomski Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures J Bone Miner Metab 25 2007 310 319
5. S.F. Lei, Y.Z. Liu, F.Y. Deng, Y.M. Li, M.X. Li, and H.W. Deng Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese J Bone Miner Metab 23 2005 323 328
6. J.B. Richards, F.K. Kavvoura, and F. Rivadeneira Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture Ann Intern Med 151 2009 528 537
7. J.M. Johnston, J.A. Cauley, and M. Ganguli APOE 4 and hip fracture risk in a community-based study of older adults J Am Geriatr Soc 47 1999 1342 1345
8. M.H. Knapen, K. Hamulyak, and C. Vermeer The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein) and urinary calcium excretion Ann Intern Med 111 1989 1001 1005
9. M. Shiraki, Y. Shiraki, and C. Aoki Association of bone mineral density with apolipoprotein E phenotype J Bone Miner Res 12 1997 1438 1445
10. L.M. Salamone, J.A. Cauley, and J. Zmuda Apolipoprotein E gene polymorphism and bone loss: estrogen status modifies the influence of apolipoprotein E on bone loss J Bone Miner Res 15 2000 308 314
11. H. Hirasawa, S. Tanaka, and A. Sakai ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells J Bone Miner Res 22 2007 1020 1030
12. M. Kohlmeier, J. Saupe, K. Schaefer, and G. Asmus Bone fracture history and prospective bone fracture risk of hemodialysis patients are related to apolipoprotein E genotype Calcif Tissue Int 62 1998 278 281
13. D.G. von Muhlen, E. Barrett-Connor, D.L. Schneider, P.A. Morin, and P. Parry Osteoporosis and apolipoprotein E genotype in older adults: the Rancho Bernardo study Osteoporos Int 12 2001 332 335 (Pubitemid 34912741)
14. T. Stulc, R. Ceska, A. Horinek, and J. Stepan Bone mineral density in patients with apolipoprotein E type 2/2 and 4/4 genotype Physiol Res 49 2000 435 439
15. L.U. Gerdes, P. Vestergaard, A.P. Hemann, and Mosekilde Regional and hormone dependent effects of apolipoprotein E genotype on changes in bone mineral in perimenopausal women J Bone Miner Res 16 2001 1906 1916
16. J.A. Cauley, J.M. Zmuda, K. Yaffe, L.H. Kuller, R.E. Ferrell, and S.R. Wisniewski Apolipoprotein E polymorphism: a new genetic marker of hip fracture risk-the study of osteoporotic fractures J Bone Miner Res 14 1999 1175 1181
17. C. Cooper, G. Campion, and L.J. Melton Hip fractures in the elderly: a world-wide projection Osteoporosis Int 2 1992 285 309
18. U. Krishna, and R.U. Mehta Osteoporosis - incidence and implications J Obstet Gynecol India 50 2000 150 155
19. N.D. Aggarwal, G.D. Singh, R. Aggarwal, R.P. Kaur, and S.P. Thapar A survey of osteoporosis using the calcaneum as an index Int Orthop 10 1986 147 153
20. O. Johnell, B. Gullberg, E. Allander, and J.A. Kanis The apparent incidence of hip fracture in Europe: a study of national register sources. MEDOS Study Group Osteoporos Int 2 1992 298 302
21. A. Gupta Osteoporosis in India-the nutritional hypothesis A. Mithal, D.S. Rao, M. Zaidi, Metabolic bone disorders 1998 Indian Society for Bone and Mineral Research 115 132
22. J.R. Long, L.J. Zhao, and P.Y. Liu Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes BMC Genet 5 2004 11 17
23. J.R. Long, P.Y. Liu, and Y.J. Liu APOE haplotypes influence bone mineral density in Caucasian males but not females Calcif Tissue Int 75 2004 299 304
24. E. Appel, S. Eisenberg, and J. Roitelman Improved PCR amplification/Hhal restriction for unambiguous determination of apolipoprotein E alleles Clin Chem 41 1995 187 190
25. L. Excoffier, G. Laval, and S. Schneider Arlequin ver 3.0: an integrated software package for population genetics data analysis Evolutionary Bioinformatics Online 1 2005 47 50
26. I. Menashe, P.S. Rosenberg, and B.E. Chen PGA: power calculator for case-control genetic association analyses BMC Genet 9 2008 36
27. B. Devlin, and K. Roeder Genomic control for association studies Biometrics 55 1999 997 1004
28. S.L. Booth, K.L. Tucker, and H. Chen Dietary vitamin K intakes are associated with hip fractures but not with bone mineral density in elderly men and women Am J Clin Nutr 71 2000 1201 1208
29. E.R. Martin, E.H. Lai, and J.R. Gilbert SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease Am J Hum Genet 67 2000 383 394