Expression of various glutamate receptors including N-methyl-D-aspartate receptor (NMDAR) in an ovarian teratoma removed from a young woman with anti-NMDAR encephalitis

Internal Medicine

Volumn 49, Issue 19, 2010, Pages 2167-2173

  Tachibana, Naoko ^a   Shirakawa, Takashi ^a   Ishii, Keiko ^a   Takahashi, Yukitoshi ^b   Tanaka, Keiko ^c   Arima, Kunimasa ^d   Yoshida, Takuhiro ^e   Ikeda, Shu ichi ^e  

^a Okaya City Hospital   (Japan)

^b SHIZUOKA INSTITUTE OF EPILEPSY AND NEUROLOGICAL DISORDERS   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

^d National Center Hospital of Neurology and Psychiatry   (Japan)

^e SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Glutamate receptor; Limbic encephalitis; N methyl D aspartate receptor (NMDAR); Ovarian teratoma; Paraneoplastic syndrome

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; RECEPTOR ANTIBODY;

ADULT; ARTICLE; CASE REPORT; DISEASE SEVERITY; DYSKINESIA; ENCEPHALITIS; FEMALE; FLU LIKE SYNDROME; GRAND MAL SEIZURE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERSALIVATION; IMMUNOREACTIVITY; MENTAL DISEASE; OVARY TERATOMA; PROTEIN EXPRESSION; SALPINGOOOPHORECTOMY;

AUTOANTIBODIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; OVARIAN NEOPLASMS; PARANEOPLASTIC SYNDROMES, NERVOUS SYSTEM; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; TERATOMA; YOUNG ADULT;

EID: 77958096263     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.49.4069     Document Type: Article

References (23)

1. Sansing LH, Tüzün E, Ko MW, Baccon J, Lynch DR, Dalmau J. A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol 3: 291-296, 2007.
2. Dalmau J, Gleichman A, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7: 1091-1098, 2008.
3. Kamei S, Kuzuhara S, Ishihara M, et al. Nationwide survey of acute juvenile female non-herpetic encephalitis in Japan: relationship to anti-N-methyl-D-aspartate receptor encephalitis. Intern Med 48: 673-679, 2009.
4. Vitaliani R, Mason W, Ances B, Zwerdling T, Jiang Z, Dalmau J. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol 58: 594-604, 2005.
5. Dalmau J, Tüzün E, Wu H-Y, et al. Paraneoplastic N-methyl-Daspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 61: 25-36, 2007.
6. Iizuka T, Sakai F, Ide T, et al. Anti-NMDA receptor encephalitis in Japan. Long-term outcome without tumor removal. Neurology 70: 504-511, 2008.
7. Bloom FE. Neurotransmission and the central nervous system. In: Goodman & Gilman's The Pharmacological Basis of Therapeutics. Brunton LL, Lazo JS, Parker KL, Eds. McGraw-Hill, New York, 2006: 317-340.
8. Groc L, Heine M, Cousins SL, et al. NMDA receptor surface mobility depends on NR2A-2B subunits. Proc Natl Acad Sci USA 103: 18769-18774, 2006.
9. Takahashi Y, Mori H, Mishina M, et al. Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua. Neurology 61: 891-896, 2003.
10. Bataller L, Leopa KA, Wu GF, Rossi JE, Rosenfeld MR, Dalmau J. Autoimmune limbic encephalitis in 39 patients: immunophenotypes and outcomes. J Neurol Neurosurg Psychiatry 78: 381-385, 2007.
11. Takahashi Y. Epitope of autoantibodies to N-methyl-D-aspartate receptor heteromers in paraneoplastic limbic encephalitis. Ann Neurol 64: 110-111, 2008.
12. Dalmau J. Reply: epitope of autoantibodies to N-methyl-Daspartate receptor heteromers in paraneoplastic limbic encephalitis. Ann Neurol 64: 111-112, 2008.
13. Seki M, Suzuki S, Iizuka T, et al. Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. J Neurol Neurosurg Psychiatry 79: 324-326, 2008.
14. Tzn E, Zhou L, Baehring JM, Bannykh S, Rosenfeld MR, Dalmau J. Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma. Acta Neuropathol 118: 737-743, 2009.
15. Hughes EG, Peng X, Gleichman AJ, et al. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci 30: 5866-5875, 2010.
16. Ishiura H, Matsuda S, Higashihara M, et al. Response of anti- NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology 71: 1921-1922, 2008.
17. Wong-Kisiel LC, Ji T, Renaud DL, et al. Response to immunotherapy in a 20-month-old boy with anti-NMDA receptor encephalitis. Neurology 74: 1550-1551, 2010.
18. Lai M, Hughes EG, Peng X, et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol 65: 424-434, 2009.
19. Graus F, Boronat A, Xifro X, et al. The expanding clinical profile of anti-AMPA receptor encephalitis. Neurology 74: 857-859, 2010.
20. Niehusmann P, Dalmau J, Rudlowski C, et al. Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with newonset epilepsy. Arch Neurol 66: 458-464, 2009.
21. Florance NR, Davis RL, Lam C, et al. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol 66: 11-18, 2009.
22. Eker A, Saka E, Dalmau J, et al. Testicular teratoma and anti-1Nmethyl- D-aspartate receptor-associated encephalitis. J Neurol Neurosurg Psychiatry 79: 1082-1083, 2008.
23. Novillo-Lopez ME, Rossi J, Dalmau J, Masjuan J. Treatmentresponsive encephalitis and NMDA receptor antibodies in man. Neurology 70: 728-729, 2008.