Transient activation of the ALT pathway in human primary fibroblasts exposed to high-LET radiation

Radiation Research

Volumn 174, Issue 5, 2010, Pages 539-549

  Berardinelli, F ^a,b   Antoccia, A ^a,b   Cherubini, R ^c   De Nadal, V ^c   Gerardi, S ^c   Cirrone, G A P ^d   Tanzarella, C ^a,b   Sgura, A ^a,b  

^a ROMA TRE UNIVERSITY   (Italy)

^b INFN SEZIONE DI ROMA   (Italy)

^c LABORATORI NAZIONALI DI LEGNARO   (Italy)

^d INFN LABORATORI NAZIONALI DEL SUD   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; LINEAR ENERGY TRANSFER; PRIORITY JOURNAL; PROTON RADIATION; RADIATION EXPOSURE; SISTER CHROMATID EXCHANGE; TELOMERE;

DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GENOME, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LINEAR ENERGY TRANSFER; NUCLEAR PROTEINS; PROTEIN TRANSPORT; SISTER CHROMATID EXCHANGE; TELOMERASE; TELOMERE; TIME FACTORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 77958090630     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2127.1     Document Type: Article

References (42)

1. R. A. DePinho, The age of cancer. Nature 408, 248-254 (2000).
2. E. H. Blackburn, Telomere states and cell fates. Nature 408, 53-56 (2000).
3. W. E. Wright, M. A. Piatyszek, W. E. Rainey, W. Byrd and J. W. Shay, Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18, 173-179 (1996).
4. J. Yui, C. P. Chiu and P. M. Lansdorp, Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood 91, 3255-3262 (1998).
5. C. W. Greider and E. H. Blackburn, Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413 (1985).
6. P. M. Lansdorp, N. P. Verwoerd, F. M. van de Rijke, V. Dragowska, M. T. Little, R. W. Dirks, A. K. Raap and H. J. Tanke, Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5, 685-691 (1996).
7. J. Yang, E. Chang, A. M. Cherry, C. D. Bangs, Y. Oei, A. Bodnar, A. Bronstein, C. P. Chiu and G. S. Herron, Human endothelial cell life extension by telomerase expression. J. Biol. Chem. 274, 26141-26148 (1999).
8. N. W. Kim, M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Coviello, W. E. Wright, S. L. Weinrich and J. W. Shay, Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
9. J. D. Henson, A. A. Neumann, T. R. Yeager and R. R. Reddel, Alternative lengthening of telomeres in mammalian cells. Oncogene 21, 598-610 (2002).
10. T. R. Yeager, A. A. Neumann, A. Englezou, L. I. Huschtscha, J. R. Noble and R. R. Reddel, Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. Cancer Res. 59, 4175-4179 (1999).
11. G. Wu, X. Jiang, W. H. Lee and P. L. Chen, Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen breakage syndrome 1. Cancer Res. 63, 2589-2595 (2003).
12. R. R. Reddel and T. M. Bryan, Alternative lengthening of telomeres: dangerous road less travelled. Lancet 361, 1840-1841 (2003).
13. S. M. Bailey, M. A. Brenneman and E. H. Goodwin, Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res. 32, 3743-3751 (2004).
14. M. A. Dunham, A. A. Neumann, C. L. Fasching and R. R. Reddel, Telomere maintenance by recombination in human cells. Nat. Genet. 26, 447-450 (2000).
15. T. M. Bryan, A. Englezou, J. Gupta, S. Bacchetti and R. R. Reddel, Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240-4248 (1995).
16. M. P. Hande, E. Samper, P. Lansdorp and M. A. Blasco, Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144, 589-601 (1999).
17. H. Niida, Y. Shinkai, M. P. Hande, T. Matsumoto, S. Takehara, M. Tachibana, M. Oshimura, P. M. Lansdorp and Y. Furuichi, Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA. Mol. Cell Biol. 20, 4115-4127 (2000).
18. A. Ayouaz, C. Raynaud, C. Heride, D. Revaud and L. Sabatier, Telomeres: hallmarks of radiosensitivity. Biochimie 90, 60-72 (2008).
19. C. Ducray and L. Sabatier, Role of chromosome instability in long term effect of manned-space missions. Adv. Space Res. 22, 597-602 (1998).
20. D. Neuhof, A. Ruess, F. Wenz and K. J. Weber, Induction of telomerase activity by irradiation in human lymphoblasts. Radiat. Res. 155, 693-697 (2001).
21. A. Sgura, A. Antoccia, F. Berardinelli, R. Cherubini, S. Gerardi, C. Zilio and C. Tanzarella, Telomere length in mammalian cells exposed to low-and high-LET radiations. Radiat. Prot. Dosimetry 122, 176-179 (2006).
22. M. Durante, Y. Furusawa and E. Gotoh, A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry. Int. J. Radiat. Biol. 74, 457-462 (1998).
23. S. Ferlicot, N. Youssef, D. Feneux, F. Delhommeau, V. Paradis and P. Bedossa, Measurement of telomere length on tissue sections using quantitative fluorescence in situ hybridization (Q-FISH). J. Pathol. 200, 661-666 (2003).
24. S. Perner, S. Bruderlein, C. Hasel, I. Waibel, A. Holdenried, N. Ciloglu, H. Chopurian, K. V. Nielsen, A. Plesch and P. Moller, Quantifying telomere lengths of human individual chromosome arms by centromere-calibrated fluorescence in situ hybridization and digital imaging. Am. J. Pathol. 163, 1751-1756 (2003).
25. H. Wege, M. S. Chui, H. T. Le, J. M. Tran and M. A. Zern, SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity. Nucleic Acids Res. 31, E3 (2003).
26. N. W. Kim and F. Wu, Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res. 25, 2595-2597 (1997).
27. S. M. Bailey, E. H. Goodwin and M. N. Cornforth, Strand-specific fluorescence in situ hybridization: the CO-FISH family. Cytogenet. Genome Res. 107, 14-17 (2004).
28. S. Gonzalo, I. Jaco, M. F. Fraga, T. Chen, E. Li, M. Esteller and M. A. Blasco, DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat. Cell Biol. 8, 416-424 (2006).
29. M. N. Cornforth and R. L. Eberle, Termini of human chromosomes display elevated rates of mitotic recombination. Mutagenesis 16, 85-89 (2001).
30. H. Terato, R. Tanaka, Y. Nakaarai, T. Nohara, Y. Doi, S. Iwai, R. Hirayama, Y. Furusawa and H. Ide, Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams. J. Radiat. Res. (Tokyo) 49, 133-146 (2008).
31. S. Oikawa and S. Kawanishi, Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett. 453, 365-368 (1999).
32. N. Sitte, G. Saretzki and T. von Zglinicki, Accelerated telomere shortening in fibroblasts after extended periods of confluency. Free Radic. Biol. Med. 24, 885-893 (1998).
33. H. Der-Sarkissian, S. Bacchetti, L. Cazes and J. A. Londono-Vallejo, The shortest telomeres drive karyotype evolution in transformed cells. Oncogene 23, 1221-1228 (2004).
34. S. Lantuejoul, C. Salon, J. C. Soria and E. Brambilla, Telomerase expression in lung preneoplasia and neoplasia. Int. J. Cancer 120, 1835-1841 (2007).
35. D. Y. Liu, Z. H. Peng, G. Q. Qiu and C. Z. Zhou, Expression of telomerase activity and oxidative stress in human hepatocellular carcinoma with cirrhosis. World J. Gastroenterol.9, 1859-1862 (2003).
36. M. P. Hande, P. M. Lansdorp and A. T. Natarajan, Induction of telomerase activity by in vivo X-irradiation of mouse splenocytes and its possible role in chromosome healing. Mutat. Res. 404, 205-214 (1998).
37. F. Leteurtre, X. Li, E. Gluckman and E. D. Carosella, Telomerase activity during the cell cycle and in gamma-irradiated hematopoietic cells. Leukemia 11, 1681-1689 (1997).
38. J. Xing, Y. Zhu, H. Zhao, H. Yang, M. Chen, M. R. Spitz and X. Wu, Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation. Cancer Epidemiol. Biomarkers Prev. 16, 606-609 (2007).
39. T. A. Morrish and C. W. Greider, Short telomeres initiate telomere recombination in primary and tumor cells. PLoS Genet. 5, e1000357 (2009).
40. O. E. Bechter, J. W. Shay and W. E. Wright, The frequency of homologous recombination in human ALT cells. Cell Cycle 3, 547-549 (2004).
41. Z. H. Zhong, W. Q. Jiang, A. J. Cesare, A. A. Neumann, R. Wadhwa and R. R. Reddel, Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J. Biol. Chem. 282, 29314-29322 (2007).
42. z/2 mice. Environ. Mol. Mutagen. 49, 467-475 (2008).