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Volumn 11, Issue 6, 2010, Pages 421-426

Gene therapy for erectile dysfunction: What is the future?

Author keywords

Corpora cavernous; Erectile dysfunction; Gene transfer; Naked DNA, Overactive bladder; Phase I trial; Plasmid; Smooth muscle

Indexed keywords

LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; NAKED DNA; PAPAVERINE; PHENTOLAMINE; PHOSPHODIESTERASE V INHIBITOR; PLASMID DNA; PROSTAGLANDIN E1; SILDENAFIL; TADALAFIL; VARDENAFIL;

EID: 77958085764     PISSN: 15272737     EISSN: 15346285     Source Type: Journal    
DOI: 10.1007/s11934-010-0145-1     Document Type: Review
Times cited : (9)

References (15)
  • 1
    • 72749125839 scopus 로고    scopus 로고
    • DNA as therapeutics; An update
    • 1:STN:280:DC%2BC3czmsVektA%3D%3D 10.4103/0250-474X.58169 20502565
    • P Saraswat RR Soni A Bhandari BP Nagori 2009 DNA as therapeutics; an update Indian J Pharm Sci 71 488 498 1:STN:280:DC%2BC3czmsVektA%3D%3D 10.4103/0250-474X.58169 20502565
    • (2009) Indian J Pharm Sci , vol.71 , pp. 488-498
    • Saraswat, P.1    Soni, R.R.2    Bhandari, A.3    Nagori, B.P.4
  • 2
    • 0242266610 scopus 로고    scopus 로고
    • Clinical gene therapy for nonmalignant disease
    • DOI 10.1016/S0002-9343(03)00447-9
    • TA Ratko JP Cummings J Blebea KA Matuszewski 2003 Clinical gene therapy for nonmalignant disease Am J Med 115 560 569 1:CAS:528:DC%2BD3sXos1Omtrs%3D 10.1016/S0002-9343(03)00447-9 14599636 (Pubitemid 37352803)
    • (2003) American Journal of Medicine , vol.115 , Issue.7 , pp. 560-569
    • Ratko, T.A.1    Cummings, J.P.2    Blebea, J.3    Matuszewski, K.A.4
  • 3
    • 0033635776 scopus 로고    scopus 로고
    • Potassium channels: Molecular defects, diseases, and therapeutic opportunities
    • 1:CAS:528:DC%2BD3MXislWksA%3D%3D 11121510
    • CC Shieh M Coghlan JP Sullivan M Gopalakrishnan 2000 Potassium channels: molecular defects, diseases, and therapeutic opportunities Pharmacol Rev 52 557 594 1:CAS:528:DC%2BD3MXislWksA%3D%3D 11121510
    • (2000) Pharmacol Rev , vol.52 , pp. 557-594
    • Shieh, C.C.1    Coghlan, M.2    Sullivan, J.P.3    Gopalakrishnan, M.4
  • 4
    • 0036118903 scopus 로고    scopus 로고
    • Molecular diversity of vascular potassium channel isoforms
    • DOI 10.1046/j.1440-1681.2002.03651.x
    • VP Korovkina SK England 2002 Molecular diversity of vascular potassium channel isoforms Clin Exp Pharmacol Physiol 29 317 323 1:CAS:528: DC%2BD38XisVKmsL8%3D 10.1046/j.1440-1681.2002.03651.x 11985543 (Pubitemid 34227067)
    • (2002) Clinical and Experimental Pharmacology and Physiology , vol.29 , Issue.4 , pp. 317-323
    • Korovkina, V.P.1    England, S.K.2
  • 5
    • 0036461641 scopus 로고    scopus 로고
    • Detection and implications of potassium channel alterations
    • DOI 10.1016/S1537-1891(02)00121-0, PII S1537189102001210
    • VP Korovkina SK England 2002 Detection and implications of potassium channel alterations Vascul Pharmacol 38 3 12 1:CAS:528:DC%2BD38Xns1ersLY%3D 10.1016/S1537-1891(02)00121-0 12378820 (Pubitemid 36398285)
    • (2002) Vascular Pharmacology , vol.38 , Issue.1 , pp. 3-12
    • Korovkina, V.P.1    England, S.K.2
  • 7
    • 23944468730 scopus 로고    scopus 로고
    • Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder
    • DOI 10.1152/ajprenal.00060.2005
    • KS Thorneloe AL Meredith AM Knorn, et al. 2005 Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder Am J Physiol Renal Physiol 289 F604 F610 1:CAS:528:DC%2BD2MXhtVWktrfL 10.1152/ajprenal.00060.2005 15827347 (Pubitemid 41208476)
    • (2005) American Journal of Physiology - Renal Physiology , vol.289 , Issue.3
    • Thorneloe, K.S.1    Meredith, A.L.2    Knorn, A.M.3    Aldrich, R.W.4    Nelson, M.T.5
  • 8
    • 24944477440 scopus 로고    scopus 로고
    • Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel
    • DOI 10.1113/jphysiol.2005.093823
    • ME Werner P Zvara AL Meredith, et al. 2005 Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel J Physiol 567 545 556 1:CAS:528:DC%2BD2MXhtVaqur%2FN 10.1113/jphysiol.2005.093823 16020453 (Pubitemid 41301050)
    • (2005) Journal of Physiology , vol.567 , Issue.2 , pp. 545-556
    • Werner, M.E.1    Zvara, P.2    Meredith, A.L.3    Aldrich, R.W.4    Nelson, M.T.5
  • 9
    • 77649267082 scopus 로고    scopus 로고
    • Gene therapy in the management of erectile dysfunction (ED): Past, present, and future
    • 1:CAS:528:DC%2BC3cXhsVSjsb4%3D 20333343 This is a good complementary review of gene transfer for therapy for erectile dysfunction
    • A Melman KP Davies 2009 Gene therapy in the management of erectile dysfunction (ED): past, present, and future Scientific World Journal 9 846 854 1:CAS:528:DC%2BC3cXhsVSjsb4%3D 20333343 This is a good complementary review of gene transfer for therapy for erectile dysfunction
    • (2009) Scientific World Journal , vol.9 , pp. 846-854
    • Melman, A.1    Davies, K.P.2
  • 10
    • 33845774784 scopus 로고    scopus 로고
    • hMaxi-K gene transfer in males with erectile dysfunction: Results of the first human trial
    • DOI 10.1089/hum.2006.17.1165
    • A Melman N Bar-Chama A McCullough, et al. 2006 hMaxi-K gene transfer in males with erectile dysfunction: results of the first human trial Hum Gene Ther 17 1165 1176 1:CAS:528:DC%2BD28XhtlGktLfJ 10.1089/hum.2006.17.1165 17134370 (Pubitemid 44975134)
    • (2006) Human Gene Therapy , vol.17 , Issue.12 , pp. 1165-1176
    • Melman, A.1    Bar-Chama, N.2    McCullough, A.3    Davies, K.4    Christ, G.5
  • 11
    • 0033533669 scopus 로고    scopus 로고
    • Virus treatment questioned after gene therapy death
    • 1:CAS:528:DyaK1MXmvFCns7k%3D 10.1038/43977 10524611
    • S Lehrman 1999 Virus treatment questioned after gene therapy death Nature 401 517 518 1:CAS:528:DyaK1MXmvFCns7k%3D 10.1038/43977 10524611
    • (1999) Nature , vol.401 , pp. 517-518
    • Lehrman, S.1
  • 12
    • 77649242689 scopus 로고    scopus 로고
    • Smooth-Muscle-Specific Gene Transfer with the Human Maxi-K Channel Improves Erectile Function and Enhances Sexual Behavior in Atherosclerotic Cynomolgus Monkeys
    • Dec 25 (Epub ahead of print). This report demonstrates the versatility of plasmid-based therapy. In this case, the hSlo gene was used in a plasmid backbone with a smooth muscle-activated-only promoter. In addition, it demonstrated that the product could correct erectile dysfunction that was caused by atherosclerosis in a primate model
    • •• Christ GJ, Andersson KE, Williams K, et al.: Smooth-Muscle-Specific Gene Transfer with the Human Maxi-K Channel Improves Erectile Function and Enhances Sexual Behavior in Atherosclerotic Cynomolgus Monkeys. Eur Urol 2008 Dec 25 (Epub ahead of print). This report demonstrates the versatility of plasmid-based therapy. In this case, the hSlo gene was used in a plasmid backbone with a smooth muscle-activated-only promoter. In addition, it demonstrated that the product could correct erectile dysfunction that was caused by atherosclerosis in a primate model.
    • (2008) Eur Urol
    • Christ, G.J.1    Andersson, K.E.2    Williams, K.3
  • 13
    • 34447559512 scopus 로고    scopus 로고
    • The Treatment Satisfaction Scale (TSS) is a sensitive measure of treatment effectiveness for both patients and partners: Results of a randomized controlled trial with vardenafil
    • DOI 10.1111/j.1743-6109.2007.00527.x
    • R Rosen I Goldstein XY Huang, et al. 2007 The Treatment Satisfaction Scale (TSS) is a sensitive measure of treatment effectiveness for both patients and partners: results of a randomized controlled trial with vardenafil J Sex Med 4 1009 1021 1:CAS:528:DC%2BD2sXptFKjtr4%3D 10.1111/j.1743-6109.2007.00527.x 17627746 (Pubitemid 47079634)
    • (2007) Journal of Sexual Medicine , vol.4 , Issue.4 , pp. 1009-1021
    • Rosen, R.1    Goldstein, I.2    Huang, X.-Y.3    Bangerter, K.4    Taylor, T.5
  • 14
    • 70350066071 scopus 로고    scopus 로고
    • Gene transfer for erectile dysfunction: Will this novel therapy be accepted by urologists?
    • 10.1097/MOU.0b013e3283314985 19741539 This manuscript reports the results of a web-based survey to determine if clinical urologists would be willing to utilize gene transfer in their practice
    • A Melman L Rojas G Christ 2009 Gene transfer for erectile dysfunction: will this novel therapy be accepted by urologists? Curr Opin Urol 19 595 600 10.1097/MOU.0b013e3283314985 19741539 This manuscript reports the results of a web-based survey to determine if clinical urologists would be willing to utilize gene transfer in their practice
    • (2009) Curr Opin Urol , vol.19 , pp. 595-600
    • Melman, A.1    Rojas, L.2    Christ, G.3
  • 15
    • 74049146039 scopus 로고    scopus 로고
    • Standards for clinical trials in male sexual dysfunctions
    • 1:CAS:528:DC%2BC3cXitFGjtr0%3D 10.1111/j.1743-6109.2009.01623.x 20092447 This wonderful review forms a basis of understanding for the basic requirements of clinical trials
    • H Porst Y Vardi E Akkus, et al. 2010 Standards for clinical trials in male sexual dysfunctions J Sex Med 7 414 444 1:CAS:528:DC%2BC3cXitFGjtr0%3D 10.1111/j.1743-6109.2009.01623.x 20092447 This wonderful review forms a basis of understanding for the basic requirements of clinical trials
    • (2010) J Sex Med , vol.7 , pp. 414-444
    • Porst, H.1    Vardi, Y.2    Akkus, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.