A novel controlled drug delivery system based on pH-responsive hydrogels included in soft gelatin capsules

Acta Biomaterialia

Volumn 6, Issue 12, 2010, Pages 4650-4656

  Frutos, G ^a   Prior Cabanillas, A ^b   Paris R ^c   Quijada Garrido, I ^c  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b JUSTE SAQF   (Spain)

^c INSTITUTO DE CIENCIA Y TECNOLOGÍA DE POLÍMEROS   (Spain)

Author keywords

Capsules; Diltiazem; Drug release; Stimuli responsive hydrogels; Zero order release

Indexed keywords

CARBOXYLATION; CONTROLLED DRUG DELIVERY; DRUG DOSAGE; HYDROGELS; MONOMERS; POLYETHYLENE GLYCOLS; TARGETED DRUG DELIVERY;

CAPSULE; DILTIAZEM; DILTIAZEM HYDROCHLORIDE; DOSAGE FORMS; DRUG RELEASE; METHACRYLIC ACIDS; MONOMER COMPOSITIONS; STIMULUS-RESPONSIVE HYDROGELS; SWELLING PROCESS; ZERO-ORDER RELEASE;

MAGNETIC RESONANCE IMAGING;

DILTIAZEM; GELATIN;

ARTICLE; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; HYDROGEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 77958083023     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.07.018     Document Type: Article

References (36)

1. P. Gupta, K. Vermani, and S. Garg Hydrogels: from controlled release to pH-responsive drug delivery Drug Discov Today 7 2002 569 579
2. Y. Qiu, and K. Park Environment-sensitive hydrogels for drug delivery Adv Drug Del Rev 53 2001 321 339
3. T.R. Hoare, and D.S. Kohane Hydrogels in drug delivery: progress and challenges Polymer 49 2008 1993 2007
4. A.K. Bajpai, S.K. Shukla, S. Bhanu, and S. Kankane Responsive polymers in controlled drug delivery Prog Polym Sci 33 2008 1088 1118
5. C.L. Bell, and N.A. Peppas Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol) Biomaterials 17 1996 1203 1218
6. J. Zhang, and N.A. Peppas Synthesis and characterization of pH- and temperature-sensitive poly(methacrylic acid)/poly(N-isopropylacrylamide) interpenetrating polymeric networks Macromolecules 33 2000 102 107
7. R.G. Sousa, A. Prior-Cabanillas, I. Quijada-Garrido, and J.M. Barrales-Rienda Dependence of copolymer composition, swelling history, and drug concentration on the loading of diltiazem hydrochloride (DIL·HCl) into poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels and its release behaviour from hydrogel slabs J Control Release 102 2005 595 606
8. R. París, J.M. Barrales-Rienda, and I. Quijada-Garrido Dynamic swelling of hydrogels based on random terpolymers of N-isopropylacrylamide, methacrylic acid and poly(ethylene glycol) macromonomer Polymer 50 2009 2065 2074
9. I. Quijada-Garrido, A. Prior-Cabanillas, R. París, G. Frutos, and J.M. Barrales-Rienda Water transport properties of pH-responsive hydrogels based on poly(methacrylic acid) with polyether side chains by magnetic resonance imaging Macromol Chem Phys 210 2009 520 530
10. A. Prior-Cabanillas, J.M. Barrales-Rienda, G. Frutos, and I. Quijada-Garrido Swelling behaviour of hydrogels from methacrylic acid and poly(ethylene glycol) side chains by magnetic resonance imaging Polym Int 56 2007 506 511
11. M. Torres-Lugo, M. García, R. Record, and N.A. Peppas Physicochemical behavior and cytotoxic effects of p(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins J Control Release 80 2002 197 205
12. H. Vihola, A. Laukkanen, L. Valtola, H. Tenhu, and J. Hirvonen Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam) Biomaterials 26 2005 3055 3064
13. V. Pillay, and R. Fassihi In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract. I. Comparison of pH-responsive drug release and associated kinetics J Control Release 59 1999 229 242
14. M.D. Kurkuri, and T.M. Aminabhavi Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine J Control Release 96 2004 9 20
15. B. Kim, and N.A. Peppas In vitro release behavior and stability of insulin in complexation hydrogels as oral drug delivery carriers Int J Pharm 266 2003 29 37
16. J. Gu, F. Xia, Y. Wu, X. Qu, Z. Yang, and L. Jiang Programmable delivery of hydrophilic drug using dually responsive hydrogel cages J Control Release 117 2007 396 402
17. J.P.K. Tan, C.H. Goh, and K.C. Tam Comparative drug release studies of two cationic drugs from pH-responsive nanogels Eur J Pharm Sci 32 2007 340 348
18. S. Conti, L. Maggi, L. Segale, E. Ochoa Machiste, U. Conte, and P. Grenier Matrices containing NaCMC and HPMC. 2. Swelling and release mechanism study Int J Pharm 333 2007 143 151
19. S. Mandal, S.K. Basu, and B. Sa Sustained release of a water-soluble drug from alginate matrix tablets prepared by wet granulation method AAPS PharmSciTech 10 2009 1348 1356
20. Y.E.S. Hamza, and M.H. Aburahma Design and in vitro evaluation of novel sustained-release double-layer tablets of lornoxicam: utility of cyclodextrin and xanthan gum combination AAPS PharmSciTech 10 2009 1357 1367
21. J. Zarate, M. Igartua, R.M. Hernandez, and J.L. Pedraz Polymeric materials and formulation technologies for modified-release tablet development Mini-Rev Med Chem 9 2009 1504 1517
22. Gambhire MN, Ambade KW, Kurmi SD, Kadam VJ, Jadhav KR. Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS PharmSciTech 2007;8.
23. Díez-Peña E, Frutos P, Frutos G, Quijada-Garrido I, Barrales-Rienda JM. The influence of the copolymer composition on the diltiazem hydrochloride release from a series of pH-sensitive poly[(N-isopropycrylamide)- co-(meth-acrylic acid) hydrogels. AAPS PharmSciTech 2004;5.
24. F. Alvarez-Manceñido, M. Landin, and R. Martínez-Pacheco Konjac glucomannan/xanthan gum enzyme sensitive binary mixtures for colonic drug delivery Eur J Pharm Biopharm 69 2008 573 581
25. N. Rouge, P. Buri, and E. Doelker Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery Int J Pharm 136 1996 117 139
26. E. Diez-Peña, I. Quijada-Garrido, and J.M. Barrales-Rienda Analysis of the swelling dynamics of cross-linked P(N-iPAAm-co-MAA) copolymers and their homopolymers under acidic medium. A kinetics interpretation of the overshooting effect Macromolecules 36 2003 2475 2483
27. I. Quijada-Garrido, A. Prior-Cabanillas, L. Garrido, and J.M. Barrales-Rienda Swelling monitorization of poly[(N-isopropylacrylamide)-co- (methacrylic acid)] copolymers by magnetic resonance imaging Macromolecules 38 2005 7434 7442
28. A. Richter, S. Howitz, D. Kuckling, and K.F. Arndt Influence of volume phase transition phenomena on the behavior of hydrogel-based valves Sensor Actuator B Chem 99 2004 451 458
29. M. Knörgen, K.F. Arndt, S. Richter, D. Kuckling, and H. Schneider Investigation of swelling and diffusion in polymers by 1H NMR imaging: LCP networks and hydrogels J Mol Struct 554 2000 69 79
30. M. Knörgen, U. Heuert, H. Schneider, D. Kuckling, S. Richter, and K.F. Arndt Investigation of swelling and diffusion in polymers by NMR imaging Macromol Symp 145 1999 83 94
31. H. Thrien-Aubin, and X.X. Zhu NMR spectroscopy and imaging studies of pharmaceutical tablets made of starch Carbohydr Polym 75 2009 369 379
32. P. Kulinowski, P. Dorozynski, R. Jachowicz, and W.P. Weglarz An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms - a tool for quantitative assessment of hydrogel formation processes J Pharm Biomed Anal 48 2008 685 693
33. H.L. Frisch Sorption and transport in glassy polymers - a review Polym Eng Sci 20 1980 2 13
34. J. Crank The mathematics of diffusion 2nd ed. 1979 Clarendon Press Oxford [chapter 2]
35. K. Yamaoka, T. Nakagawa, and T. Uno Statistical moments in pharmacokinetics J Pharmacokinet Biopharm 6 1978 547 558
36. M.L. Vueba, L.A.E. Batista De Carvalho, F. Veiga, J.J. Sousa, and M.E. Pina Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets Eur J Pharm Biopharm 58 2004 51 59