Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6850-6853

  Jiao, Guan Sheng ^a   Kim, Seongjin ^a   Moayeri, Mahtab ^b   Cregar Hernandez, Lynne ^a   McKasson, Linda ^a   Margosiak, Stephen A ^a   Leppla, Stephen H ^b   Johnson, Alan T ^a  

^a PanThera Biopharma LLC   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Anthrax; Inhibitor; Lethal factor; Small molecule

Indexed keywords

AMIDE; ANILINE; ANTIDOTE; BENZYL AMINE DERIVATIVE; PHENETHYL ALCOHOL; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ARTICLE; CLINICAL EVALUATION; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SYNTHESIS; IN VIVO STUDY; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TREATMENT OUTCOME;

ANIMALS; ANTIDOTES; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 77958072042     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.058     Document Type: Article

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