In silico point mutation and evolutionary trace analysis applied to nicotinic acetylcholine receptors in deciphering ligand-binding surfaces

Journal of Molecular Modeling

Volumn 16, Issue 10, 2010, Pages 1651-1670

  Parthiban, Marimuthu ^a,b   Shanmughavel, Piramanayagam ^a   Sowdhamini, Ramanathan ^b  

^a BHARATHIAR UNIVERSITY   (India)

^b UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

Author keywords

Evolutionary trace analysis; In silico point mutation; Ligand binding domain; Molecular docking; NAChR; Neurodegenerative disease

Indexed keywords

4 (N MALEIMIDO)BENZYLTRIMETHYLAMMONIUM; 4 (N MALEIMIDO)PHENYLTRIMETHYLAMMONIUM; ACETYLCHOLINE; AMMONIUM DERIVATIVE; BROMOACETYLCHOLINE; BUNGAROTOXIN RECEPTOR; CARBACHOL; CODEINE; CYSTEINE; DIHYDRO BETA ERYTHROIDINE; EPIBATIDINE; GALANTAMINE; GLUTAMINE; HEXAMETHONIUM; LOPHOTOXIN; MECAMYLAMINE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4; PHENCYCLIDINE; PHYSOSTIGMINE; SERINE; SEROTONIN; TUBOCURARINE CHLORIDE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; EVOLUTIONARY HOMOLOGY; LIGAND BINDING; MOLECULAR DOCKING; MUTATION; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING SITES; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; SEQUENCE ANALYSIS, PROTEIN;

EID: 77958040133     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-010-0670-3     Document Type: Article

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