Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents

Journal of the American Chemical Society

Volumn 132, Issue 41, 2010, Pages 14625-14637

  Verga, Daniela ^a   Nadai, Matteo ^b   Doria, Filippo ^a   Percivalle, Claudia ^a   Di Antonio, Marco ^b   Palumbo, Manlio ^b   Richter, Sara N ^b   Freccero, Mauro ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENTS; ALKYLATION REACTIONS; BIFUNCTIONAL; CELL LINES; CYTOTOXIC EFFECTS; DEPURINATION; ETHANETHIOL; EXCITED-STATE PROTON TRANSFER; GEL ELECTROPHORESIS; GOOD YIELD; HUMAN CANCER CELLS; L-PROLINE; LASER FLASH PHOTOLYSIS; MORPHOLINES; NAPHTHOQUINONE; ORDERS OF MAGNITUDE; PHOTOGENERATION; PHOTOPRECURSORS; PLASMID DNA; QUATERNARY AMMONIUM SALT; QUINONE METHIDE; SELECTIVITY INDEX; SEQUENCE ANALYSIS; TRIMETHYL;

ALKYLATION; AMINO ACIDS; CELL CULTURE; ELECTROPHORESIS; EXCITED STATES; GELS; KETONES; METHANOL; NAPHTHALENE; OLIGONUCLEOTIDES; PHENOLS; PHOTOLYSIS; POSITIVE IONS; SALTS;

AMMONIUM COMPOUNDS;

2,6 NAPHTHOQUINONE 6 METHIDE; 6 HYDROXY NAPHTHALENE 2 CARBALDEHYDE; 6 HYDROXYMETHYLNAPHTHALEN 2 OL; 6 METHYLAMINOMETHYLNAPHTHALEN 2 OL; [(2 HYDROXY 3 NAPHTHYL)METHYL]TRIMETHYL AMMONIUM IODIDE; AMINO ACID; AMMONIUM DERIVATIVE; BIFUNCTIONAL BINAPHTHALENYL DERIVATIVE; BINOL QUINONE METHIDE DERIVATIVE; DOUBLE STRANDED DNA; GUANINE; MORPHOLINE; NAPHTHALENE DERIVATIVE; NAPHTHOL QUATERNARY AMMONIUM; NAPHTHOQUINONE; NUCLEOPHILE; NUCLEOTIDE; OLIGONUCLEOTIDE; PLASMID DNA; QUATERNARY AMMONIUM DERIVATIVE; QUINONE DERIVATIVE; RIBOSE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; WATER;

ALKYLATION; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DNA ALKYLATION; DNA CROSS LINKING; GEL ELECTROPHORESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDRATION; IRRADIATION; LASER; PHOTOLYSIS; PHOTOREACTIVITY; PROTON TRANSPORT; SEQUENCE ANALYSIS;

ALKYLATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; NAPHTHOQUINONES; PHOTOCHEMISTRY; PURINES;

EID: 77958037184     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1063857     Document Type: Article

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