Chitosan as mucoadhesive agent to enhance absorption of therapeutic proteins encapsulated into solid lipid nanoparticles

Technical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009

Volumn 2, Issue , 2009, Pages 111-114

  Teixeira, J ^a   Gehm, C ^a   Julio A ^a   Castro, C ^b   Fonseca, J ^a   Martins, S ^a   Ferreira, D ^a   Sarmento, B ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b INSTITUTO SUPERIOR DE CIÊNCIAS DA SAÚDE EGAS MONIZ   (Portugal)

Author keywords

Absorption enhancer; Chitosan; Insulin; Oral delivery; Solid lipid nanoparticles

Indexed keywords

ABSORPTION-ENHANCERS; ANIMAL MODEL; BLOOD GLUCOSE LEVEL; COLLOIDAL CARRIERS; CULTURE CELLS; ENTEROCYTES; IN-VITRO; IN-VIVO; MUCOADHESIVE PROPERTIES; ORAL ADMINISTRATION; ORAL DELIVERY; RELIABLE SYSTEMS; SOLID LIPID NANOPARTICLES; THERAPEUTIC PROTEIN; TIGHT JUNCTIONS;

ABSORPTION; ANIMAL CELL CULTURE; BIOPOLYMERS; CELL CULTURE; CHITIN; CHITOSAN; GLUCOSE; NANOPARTICLES; NANOTECHNOLOGY;

INSULIN;

EID: 77958033815     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (5)

1. T. M. Allen, et al. Drug Delivery Systems: Entering the Mainstream, Science (2004) 303: 1818-1822.
2. A. des Rieux, et al. Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. Journal of Controlled Release (2006), 116:1-27.
3. Sarmento et al. Alginate-chitosan nanoparticles are effective for oral insulin delivery. Pharmaceutical Research (2007) 24: 2198-2206.
4. Sarmento et al. Oral bioavailability of insulin contained in polysaccharide nanoparticles Biomacromolecules (2007) 8: 3054-3060. (Pubitemid 350011625)
5. P. Artursson, Effect of Chitosan on the Permeability of monolayers of Intestinal Epithelial cells (Caco-2). Pharmaceutical Research (1994) 11: 1358-1361.