Estimating the dynamics of protofibril elongation involved in Aβ42 peptide aggregation in Alzheimer's disease

2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010

Volumn , Issue , 2010, Pages 451-453

  Ghosh, Preetam ^a   Kumar, Amit ^a   Datta, Bhaswati ^a   Rangachari, Vijayaraghavan ^a  

^a UNIVERSITY OF SOUTHERN MISSISSIPPI   (United States)

Author keywords

Chemical reaction kinetics; Ordinary differential equations

Indexed keywords

ALZHEIMER'S DISEASE; BIOPHYSICAL ANALYSIS; DIVIDE AND CONQUER; IN-VITRO; MOLECULAR LEVELS; PEPTIDE AGGREGATION; PRE-NUCLEATION; SIMULATION MODEL; THREE STAGES;

AGGLOMERATION; ASSOCIATION REACTIONS; BIOINFORMATICS; COMPUTER SIMULATION; DISEASES; ELONGATION; NEWTONIAN FLOW; NUCLEATION; PEPTIDES; RATE CONSTANTS; REACTION KINETICS;

ORDINARY DIFFERENTIAL EQUATIONS;

EID: 77958031696     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1145/1854776.1854854     Document Type: Conference Paper

References (6)

1. Harper, JD and Lansbury, PT, (1997) Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins, Annu Rev Biochem 66, 385-407.
2. Walsh, DM, Lomakin, A, Benedek, GB, Condron, MM, and Teplow, DB (1997) Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate, J Biol Chem 272, 22364-22372.
3. Nichols, MR, Moss, MA, Reed, DK, Lin, WL, Mukhopadhyay, R, Hoh, JH, Rosenberry, TL (2002) Growth of beta-amyloid(1-40) protofibrils by monomer elongation and lateral association. Characterization of distinct products by light scattering and atomic force microscopy, Biochemistry 41, 6115-6127.
4. Blackley, HK, Sanders, GH, Davies, MC, Roberts, CJ, Tendler, SJ, and Wilkinson, MJ (2000) In-situ atomic force microscopy study of beta-amyloid fibrillization, J Mol Biol 298, 833-840.
5. Lee, CC, Nayak, A, Sethuraman, A, Belfort, G, and McRae, GJ (2007) A three-stage kinetic model of amyloid fibrillation, Biophys J 92, 3448-3458.
6. Morris, AM, Watzky, MA, and Finke, RG (2009) Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature, Biochim Biophys Acta 1794, 375-397.