Hepcidin concentrations and iron homeostasis in preeclampsia

Clinical Chemistry and Laboratory Medicine

Volumn 48, Issue 10, 2010, Pages 1423-1426

  Toldi, Gergely ^a,b   Stenczer, Balázs ^b   Molvarec, Attila ^b   Takáts, Zoltán ^a   Beko, Gabriella ^a   Rigó Jr , Jánosa ^b   Vásárhelyi, Barna ^c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

hepcidin; interleukin 6; iron homeostasis; preeclampsia

Indexed keywords

FERRITIN; HEPCIDIN; INTERLEUKIN 6; IRON; TRANSFERRIN;

ADULT; ARTICLE; BLOOD CELL COUNT; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; GESTATIONAL AGE; HOMEOSTASIS; HUMAN; INFLAMMATION; IRON BINDING CAPACITY; IRON BLOOD LEVEL; MASS SPECTROMETRY; MEAN CORPUSCULAR HEMOGLOBIN; PREECLAMPSIA; PREGNANT WOMAN; PRIORITY JOURNAL; TRANSFERRIN BLOOD LEVEL;

ADOLESCENT; ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD CELL COUNT; FEMALE; FERRITINS; HOMEOSTASIS; HUMANS; INTERLEUKIN-6; IRON; MIDDLE AGED; PRE-ECLAMPSIA; PREGNANCY; YOUNG ADULT;

EID: 77958022909     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2010.290     Document Type: Article

References (18)

1. Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF 3rd, Petraglia F. Inflammation and pregnancy. Reprod Sci 2009;16:206-15.
2. Basher K, Deb K. Alteration in iron status in preeclampsia. Mymensingh Med J 2006;15:22-4.
3. Rayman MP, Barlis J, Evans RW, Redman CW, King LJ. Abnormal iron parameters in the pregnancy syndrome preeclampsia. Am J Obstet Gynecol 2002;187:412-8.
4. Balla J, Jeney V, Varga Z, Komódi E, Nagy E, Balla G. Iron homeostasis in chronic inflammation. Acta Physiol Hung 2007;94:95-106.
5. Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol 2009;122:78-86.
6. Brown MA, Lindheimer MD, de Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001;20: IX-XIV.
7. Murphy AT, Witcher DR, Luan P, Wroblewski VJ. Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 2007;110:1048-54.
8. Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006;108:3204-9.
9. Greer IA, Lyall F, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol 1994;84:937-40.
10. Casart YC, Tarrazzi K, Camejo MI. Serum levels of interleukin-6, interleukin-1beta and human chorionic gonadotropin in preeclamptic and normal pregnancy. Gynecol Endocrinol 2007;23:300-3.
11. Ishizaka N, Saito K, Furuta K, Matsuzaki G, Koike K, Noiri E, et al. Angiotensin II-induced regulation of the expression and localization of iron metabolism-related genes in the rat kidney. Hypertens Res 2007;30:195-202.
12. Xia Y, Kellems RE. Is preeclampsia an autoimmune disease? Clin Immunol 2009;133:1-12.
13. Senden IP, de Groot CJ, Steegers EA, Bertina RM, Swinkels DW. Preeclampsia and the C282Y mutation in the hemochromatosis (HFE) gene. Clin Chem 2004;50:973-4.
14. Kasvosve I, Gomo ZA, Nathoo KJ, Matibe P, Mudenge B, Loyevsky M, et al. Effect of ferroportin Q248H polymorphism on iron status in African children. Am J Clin Nutr 2005;82:1102-6.
15. Schimanski LM, Drakesmith H, Merryweather-Clarke AT, Viprakasit V, Edwards JP, Sweetland E, et al. In vitro functional analysis of human ferroportin (FPN) and hemochromatosisassociated FPN mutations. Blood 2005;105:4096-102.
16. Khatun R, Wu Y, Kanenishi K, Ueno M, Tanaka S, Hata T, et al. Immunohistochemical study of transferrin receptor expression in the placenta of pre-eclamptic pregnancy. Placenta 2003;24:870-6.
17. Chockalingam UM, Murphy E, Ophoven JC, Weisdorf SA, Georgieff MK. Cord transferrin and ferritin values in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia. J Pediatr 1987;111:283-6.
18. Schulze KJ, Christian P, Ruczinski I, Ray AL, Nath A, Wu LS, et al. Hepcidin and iron status among pregnant women in Bangladesh. Asia Pac J Clin Nutr 2008;17:451-6.