Chondroitinase ABC treatment of injured spinal cord in rats evaluation of long-term outcomes

Neural Regeneration Research

Volumn 5, Issue 16, 2010, Pages 1238-1242

  Yuan, Haifeng ^a,b   Ding, Yongli ^c   Song, Yueming ^a   Hu, Lihong ^b   Wang, Zili ^b   Liu, Hao ^a   Liu, Limin ^a   Gong, Quan ^a   Li, Tao ^a   Kong, Qingquan ^a  

^a SICHUAN UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Anterograde tracing; Biotinylated dextran amine; Chondroitinase ABC; Morphology; Neural regeneration; Spinal cord injury; Treatment

Indexed keywords

BIOLOGICAL MARKER; CHONDROITIN ABC LYASE; DEXTRAN; GLYCOSAMINOGLYCAN; NEUROFILAMENT PROTEIN; PROTEOCHONDROITIN SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; BRAIN MAPPING; CELL LABELING; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; QUANTITATIVE ANALYSIS; RAT; SPINAL CORD TRANSSECTION; SUBARACHNOID SPACE; TREATMENT DURATION;

EID: 77957984988     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2010.16.007     Document Type: Article

References (31)

1. Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus ransaction. Exp Neurol. 1996;139(2): 244-256.
2. Nakamura M, Fujimura Y, Yato Y, et al. Changes in choline acetyltransferase activity and distribution following incomplete cervical spinal cord injury in the rat. Neuroscience. 1996;75(2): 481-494.
3. Nakamae T, Tanaka N, Nakanishi K, et al. Chondroitinase ABC promotes corticospinal axon growth in organotypic cocultures. Spinal Cord. 2009;47(2):161-165.
4. Bradbury EJ, Moon LD, Popat RJ, et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature. 2002; 416(6881):636-640.
5. Caggiano AO, Zimber MP, Ganguly A, et al. Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord. J Neurotrauma. 2005;22(2):226-239.
6. De Wit J, De Winter F, Klooster J, et al. Semaphorin 3A displays a ransacti distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrix. Mol Cell Neurosci. 2005;29(1):40-55.
7. Apostolova I, Irintchev A, Schachner M. Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J Neurosci. 2006;26(30):7849-7859.
8. Dityatev A, Schachner M. The extracellular matrix and synapses. Cell Tissue Res. 2006;326(2):647-654.
9. Iseda T, Okuda T, Kane-Goldsmith N, et al. Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion. J Neurotrauma. 2008;25(4):334-349.
10. Barritt AW, Davies M, Marchand F, et al. Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci. 2006;26(42):10856-10867.
11. Shields LB, Zhang YP, Burke DA, et al. Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat. Surg Neurol. 2008;69(6):568-577.
12. McKeon RJ, Schreiber RC, Rudge JS, et al. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J Neurosci. 1991;11(11):3398-3411.
13. Huang WC, Kuo WC, Cherng JH, et al. Chondroitinase ABC promotes axonal re-growth and behavior recovery in spinal cord injury. Biochem Biophys Res Commun. 2006;349(3):963-968.
14. Cafferty WB, Bradbury EJ, Lidierth M, et al. Chondroitinase ABC-mediated plasticity of spinal sensory function. J Neurosci. 2008;28(46):11998-12009.
15. García-Alías G, Barkhuysen S, Buckle M, et al. Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nat Neurosci. 2009;12(9):1145-1151.
16. García-Alías G, Lin R, Akrimi SF, et al. Therapeutic time window for the application of chondroitinase ABC after spinal cord injury. Exp Neurol. 2008;210(2):331-338.
17. Iaci JF, Vecchione AM, Zimber MP, et al. Chondroitin sulfate proteoglycans in spinal cord contusion injury and the effects of chondroitinase treatment. J Neurotrauma. 2007;24(11): 1743-1759.
18. Ramón-Cueto A, Plant GW, Avila J, et al. Long-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants. J Neurosci. 1998;18(10): 3803-3815.
19. Ramón-Cueto A, Cordero MI, Santos-Benito FF, et al. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron. 2000;25(2): 425-435.
20. Vavrek R, Pearse DD, Fouad K. Neuronal populations capable of regeneration following a combined treatment in rats with spinal cord ransaction. J Neurotrauma. 2007;24(10):1667-1673.
21. Fouad K, Schnell L, Bunge MB, et al. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete ransaction of the spinal cord. J Neurosci. 2005;25(5):1169-1178.
22. Houle JD, Amin A, Cote MP, et al. Combining peripheral nerve grafting and matrix modulation to repair the injured rat spinal cord. J Vis Exp. 2009;(33). Pii: 1324.
23. Tom VJ, Houlé JD. Intraspinal microinjection of chondroitinase ABC following injury promotes axonal regeneration out of a peripheral nerve graft bridge. Exp Neurol. 2008;211(1):315-319.
24. Xia Y, Zhao T, Li J, et al. Antisense vimentin cDNA combined with chondroitinase ABC reduces glial scar and cystic cavity formation following spinal cord injury in rats. Biochem Biophys Res Commun. 2008;377(2):562-566.
25. The Ministry of Science and Technology of the People's Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.
26. Jakeman LB, Wei P, Guan Z, et al. Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury. Exp Neurol. 1998;154(1):170-184.
27. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed. New York: Academic Press. 1998:60-69.
28. Schiwy N, Brazda N, Müller HW. Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment. Eur J Neurosci. 2009;30(8): 1544-1553.
29. Pfeiffer-Guglielmi B, Fleckenstein B, Jung G, et al. Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme-specific antibodies. J Neurochem. 2003;85(1):73-81.
30. Satoh J, Onoue H, Arima K, et al. Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis. J Neuropathol Exp Neurol. 2005;64(2):129-138.
31. Pfeiffer-Guglielmi B, Fleckenstein B, Jung G, et al. Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme-specific antibodies. J Neurochem. 2003;85(1):73-81.