The enigma of Helicobacter pylori infection and gastric cancer

Indian Journal of Gastroenterology

Volumn 29, Issue 3, 2010, Pages 95-100

  Ghoshal, Uday C ^a   Chaturvedi, Rupesh ^b   Correa, Pelayo ^b  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bacterial genotypes; Carcinogenesis; Gastric carcinogenesis; Gastric lymphoma; Gastric tumor; Infectious diseases; Peptic ulcer; Precancerous process

Indexed keywords

AFRICA; ASIAN; BACTERIAL VIRULENCE; CANCER RISK; CARCINOGENICITY; CAUSAL ATTRIBUTION; DIETARY INTAKE; GENETIC SUSCEPTIBILITY; GEOGRAPHIC DISTRIBUTION; HELICOBACTER INFECTION; HIGH RISK POPULATION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; NONHUMAN; REVIEW; RISK REDUCTION; SOUTH AND CENTRAL AMERICA; STOMACH CANCER;

AFRICA; ANIMALS; ASIA; DIET; DISEASE PROGRESSION; GENETIC PREDISPOSITION TO DISEASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INCIDENCE; INFLAMMATION; LATIN AMERICA; PREVALENCE; RISK FACTORS; STOMACH NEOPLASMS; WORLD HEALTH;

EID: 77957974386     PISSN: 02548860     EISSN: 02548860     Source Type: Journal    
DOI: 10.1007/s12664-010-0024-1     Document Type: Review

References (48)

1. Warren R, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1:1273-5.
2. Holcombe C. Helicobacter pylori: the African enigma. Gut. 1992;33:429-31.
3. Ghoshal UC, Tiwari S, Dhingra S, et al. Frequency of Helicobacter pylori and CagA antibody in patients with gastric neoplasms and controls: the Indian enigma. Dig Dis Sci. 2008;53:1215-22.
4. Achyut BR, Tripathi P, Ghoshal UC, Moorchung N, Mittal B. Interleukin-10 (-819 C/T) and tumor necrosis factor-alpha (-308 G/A) gene variants influence gastritis and lymphoid follicle development. Dig Dis Sci. 2008;53:622-9.
5. Singh K, Ghoshal UC. Causal role of Helicobacter pylori infection in gastric cancer: an Asian enigma. World J Gastroenterol. 2006;12:1346-51.
6. Goh KL, Cheah PL, Md N, Quek KF, Parasakthi N. Ethnicity and H. Pylori as risk factors for gastric cancer in malaysia: a prospective case control study. Am J Gastroenterol. 2007;102:40-5.
7. Bravo LE, van Doom LJ, Realpe JL, Correa P. Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma? Am J Gastroenterol. 2002;97:2839-42.
8. Con SA, Valerin AL, Takeuchi H, et al. Helicobacter pylori CagA status associated with gastric cancer incidence rate variability in Costa Rican regions. J Gastroenterol. 2006;41:632-7.
9. Miwa H, Go MF, Sato N. H. pylori and gastric cancer: the Asian enigma. Am J Gastroenterol. 2002;97:1106-12.
10. IARC Monographs on the evaluation of carcinogenic risks to humans. schistosomes, liver flukes and Helicobacter pylori. IARC 1994:177-240.
11. Correa P, Haenszel W, Cuello C, et al. A model for gastric cancer epidemiology. Lancet. 1975;2:58-60.
12. Achtman M, Azuma T, Berg DE, et al. Recombination and clonal groupings within Helicobacter pylori from different geographical regions. Mol Microbiol. 1999;32:459-70.
13. Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing CagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995;55:2111-5.
14. Covacci A, Censini S, Bugnoli M, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci U S A. 1993;90:5791-5.
15. Covacci A, Telford JL, Del Giudice G, Parsonnet J, Rappuoli R. Helicobacter pylori virulence and genetic geography. Science. 1999;284:1328-33.
16. Azuma T, Yamakawa A, Yamazaki S, et al. Correlation between variation of the 3' region of the CagA gene in Helicobacter pylori and disease outcome in Japan. J Infect Dis. 2002;186:1621-30.
17. Higashi H, Tsutsumi R, Fujita A, et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A. 2002;99:14428-33.
18. Basso D, Zambon CF, Letley DP, et al. Clinical relevance of Helicobacter pylori CagA and VacA gene polymorphisms. Gastroenterology. 2008;135:91-9.
19. Atherton JC, Cao P, Peek Jr RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific VacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995;270:17771-7.
20. Peek Jr RM, Thompson SA, Donahue JP, et al. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc Assoc Am Physicians. 1998;110:531-44.
21. Aspholm-Hurtig M, Dailide G, Lahmann M, et al. Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science. 2004;305:519-22.
22. Gerhard M, Lehn N, Neumayer N, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Natl Acad Sci U S A. 1999;96:12778-83.
23. Giannakis M, Chen SL, Karam SM, Engstrand L, Gordon JI. Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. Proc Natl Acad Sci U S A. 2008;105:4358-63.
24. Nguyen T, Brunson D, Crespi CL, Penman BW, Wishnok JS, Tannenbaum SR. DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci U S A. 1992;89:3030-4.
25. Xu H, Chaturvedi R, Cheng Y, et al. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res. 2004;64:8521-5.
26. Fox JG, Beck P, Dangler CA, et al. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat Med. 2000;6:536-42.
27. Bengmark S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter Enteral Nutr. 2006;30:45-51.
28. Foryst-Ludwig A, Neumann M, Schneider-Brachert W, Naumann M. Curcumin blocks NF-kappaB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem Biophys Res Commun. 2004;316:1065-72.
29. Dorant E, van den Brandt PA, Goldbohm RA, Sturmans F. Consumption of onions and a reduced risk of stomach carcinoma. Gastroenterology. 1996;110:12-20.
30. Loh JT, Torres VJ, Cover TL. Regulation of Helicobacter pylori CagA expression in response to salt. Cancer Res. 2007;67:4709-15.
31. Camargo MC, Mera R, Correa P, et al. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:1674-87.
32. Amieva MR, El-Omar EM. Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008;134:306-23.
33. Achyut BR, Ghoshal UC, Moorchung N, Mittal B. Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and precancerous lesions. Hum Immunol. 2007;68:901-7.
34. Achyut BR, Ghoshal UC, Moorchung N, Mittal B. Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy. Mol Cell Biochem. 2009;321:103-9.
35. Tripathi S, Ghoshal U, Ghoshal UC, et al. Gastric carcinogenesis: Possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Scand J Gastroenterol. 2008;43:431-9.
36. Ghoshal UC, Tripathi S, Ghoshal U. The Indian enigma of frequent H. pylori infection but infrequent gastric cancer: is the magic key in Indian diet, host's genetic make up, or friendly bug? Am J Gastroenterol. 2007;102:2113-4.
37. Figueiredo C, Machado JC, Pharoah P, et al. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst. 2002;94:1680-7.
38. Kidd M, Lastovica AJ, Atherton JC, Louw JA. Heterogeneity in the Helicobacter pylori VacA and CagA genes: association with gastroduodenal disease in South Africa? Gut. 1999;45:499-502.
39. Letley DP, Lastovica A, Louw JA, Hawkey CJ, Atherton JC. Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the VacA s1a genotype and natural occurrence of an s2/m1 allele. J Clin Microbiol. 1999;37:1203-5.
40. Segal I, Ally R, Mitchell H. Helicobacter pylori-an African perspective. QJM. 2001;94:561-5.
41. Singh M, Prasad KN, Yachha SK, Krishnani N. Genotypes of Helicobacter pylori in children with upper abdominal pain. J Gastroenterol Hepatol. 2003;18:1018-23.
42. Kumar S, Dhar A, Srinivasan S, Jain S, Rattan A, Sharma MP. Antibodies to CagA protein are not predictive of serious gastroduodenal disease in Indian patients. Indian J Gastroenterol. 1998;17:126-8.
43. Devi SM, Ahmed I, Francalacci P, et al. Ancestral European roots of Helicobacter pylori in India. BMC Genomics. 2007;8:184.
44. Correa P, Cuello C, Duque E, et al. Gastric cancer in Colombia. III. Natural history of precursor lesions. J Natl Cancer Inst. 1976;57:1027-35.
45. Llanos G, Correa P. Morbilidad por cancer en Cartagena. Antioquia Medica. 1966;23:230-9.
46. Camargo MC, Yepez MC, Ceron C, et al. Age at acquisition of Helicobacter pylori infection: comparison of two areas with contrasting risk of gastric cancer. Helicobacter. 2004;9:262-70.
47. Whary MT, Sundina N, Bravo LE, et al. Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2005;14:1464-9.
48. MacDonald WC, Owen DA, Le N. Chronic advanced gastric cancer: clinicopathologic analysis of survival data. Hum Pathol. 2008;39:641-9.