Durezol® (difluprednate ophthalmic emulsion 0.05%) compared with pred forte® 1% ophthalmic suspension in the treatment of endogenous anterior uveitis

Journal of Ocular Pharmacology and Therapeutics

Volumn 26, Issue 5, 2010, Pages 475-483

  Foster, C Stephen ^a   DaVanzo, Robert ^b   Flynn, Thomas E ^c,d   McLeod, Kimberly ^e   Vogel, Roger ^e   Crockett, R Steve ^f  

^a MASSACHUSETTS EYE RESEARCH AND SURGERY INSTITUTION   (United States)

^b Cornerstone Eye Care ^*  (United States)

^c Ellsworth Uveitis and Retina Care   (United States)

^d Edward S Harkness Eye Institute   (United States)

^e Sirion Therapeutics Inc   (United States)

^f DATA Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIFLUPREDNATE; DUREZOL; PREDNISOLONE ACETATE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; DRUG DERIVATIVE; FLUPREDNISOLONE; GLUCOCORTICOID; PREDNISOLONE;

ADULT; ANALGESIA; ANTERIOR EYE CHAMBER; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLURRED VISION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DRY EYE; EYE IRRITATION; EYE PAIN; FEMALE; HUMAN; INTRAOCULAR PRESSURE; IRIDOCYCLITIS; LACRIMATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 3 CLINICAL TRIAL; PHOTOPHOBIA; PUNCTATE KERATITIS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; THORAX PAIN; TREATMENT OUTCOME; UVEITIS; VISUAL ACUITY; COMPARATIVE STUDY; DRUG EFFECT; EMULSION; MIDDLE AGED; SUSPENSION;

ADULT; ANTERIOR CHAMBER; ANTI-INFLAMMATORY AGENTS; EMULSIONS; FEMALE; FLUPREDNISOLONE; GLUCOCORTICOIDS; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; PREDNISOLONE; SUSPENSIONS; TREATMENT OUTCOME; UVEITIS, ANTERIOR; VISUAL ACUITY; YOUNG ADULT;

EID: 77957969696     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2010.0059     Document Type: Article

References (15)

1. Nussenblatt, R.B. The natural history of uveitis. Int. Ophthalmol. 14:303-308, 1990.
2. Darrell, R.W., Wagener, H.P., and Kurland, L.T. Epidemiology of uveitis: incidence and prevalence in a small urban community. Arch. Ophthalmol. 68:502-514, 1962.
3. Gritz, D.C., and Wong, I.G. Incidence and prevalence of uveitis in Northern California; the Northern California Epidemiology of Uveitis Study. Ophthalmology 111:491-500, 2004.
4. Ng, C.S., and Rosenthal, A.R. Principles of clinical management of uveitis. In: Easty, D.L., and Sparrow, J.M., eds. Oxford Textbook of Ophthalmology. New York: Oxford University Press, Inc.; 1999; pp. 553-559.
5. Takeda, K., Arase, S., and Takahashi, S. Side effects of topical corticosteroids and their prevention. Drugs 36(Suppl.5): 15-23, 1988.
6. Bikowski, J. The position not the presence of the halogen in corticosteroids influences potency and side effects. J. Drugs Dermatol. 5:125-130, 2006.
7. Hammer, S., Spika, I., Sippl, W., Jessen, G., Kleuser, B., Holtje, H.D., et al. Glucocorticoid receptor interactions with glucocorticoids: evaluation by molecular modeling and functional analysis of glucocorticoid receptor mutants. Steroids 68:329-339, 2003.
8. Ohno, S., et al. Association for Research in Vision & Ophthalmology. Invest. Ophthalmol. Vis. Sci. 48:E-Abstract 3905, 2007.
9. Biswas, J., Ganeshbabu, T.M., Raghavendran, S.R., et al. Efficacy and safety of 1% rimexolone versus 1% prednisolone acetate in the treatment of anterior uveitis-a randomized triple masked study. Int. Ophthalmol. 25:147-153, 2004.
10. Foster, C.S., Alter, G., DeBarge, L.R., et al. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am. J. Ophthalmol. 122:171-182, 1996.
11. Novack, G.D., Crockett, R.S., Howes, J., et al. Controlled evaluation of loteprednol etabonate and prednisolone acetate in the treatment of acute anterior uveitis. Am. J. Ophthalmol. 127:537-544, 1999.
12. Guillen-Monterrubio, O.M., Hartikainen, J., Taskinen, K., and Saari, K.M. Quantitative determination of aqueous flare and cells in healthy eyes. Acta Ophthalmol. Scand. 75:58-62, 1997.
13. Shah, S.M., Spalton, D.J., and Smith, S.E. Measurement of aqueous cells and flare in normal eyes. Br. J. Ophthalmol. 75:348-352, 1991.
14. Yang, P.Z., Wang, H., Huang, X.K., et al. [Quantitative determination of aqueous flare and cells in the eyes of patients with inflammation of anterior uvea]. Zhonghua Yan Ke Za Zhi 40:510-513, 2004.
15. Stringer, W.F. Association for Research in Vision & Ophthalmology. Invest. Ophthalmol. Vis. Sci. 50:E-Abstract 1461, 2009.