Challenging the requirement for chronic fish toxicity studies on formulated plant protection products

Toxicology Letters

Volumn 199, Issue 2, 2010, Pages 111-114

  Creton, Stuart ^a   Douglas, Mark ^b   Wheeler, James R ^c   Hutchinson, Thomas H ^d  

^a National Centre for the Replacement   (United Kingdom)

^b European Development Centre   (United Kingdom)

^c JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^d CENTRE FOR ENVIRONMENT   (United Kingdom)

Author keywords

Chronic fish toxicity; Ecotoxicology; Plant protection products; Regulatory toxicology; Risk assessment

Indexed keywords

PESTICIDE; WATER POLLUTANT;

CHRONIC TOXICITY; CROP PROTECTION; ECOTOXICITY; ECOTOXICOLOGY; EUROPEAN UNION; FISH; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TOXICITY TESTING; ANIMAL; EUROPE; PROCEDURES; TOXICITY; WATER POLLUTANT;

ANIMALS; ECOTOXICOLOGY; EUROPE; FISHES; PESTICIDES; RISK ASSESSMENT; TOXICITY TESTS, CHRONIC; WATER POLLUTANTS, CHEMICAL;

EID: 77957961863     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.08.019     Document Type: Review

References (9)

1. EC Council Directive 91/414/EEC of 15 July 1991 concerning the placing of plant protection products on the market. Official Journal of the European Communities 1991.
2. EC Guidance Document on Aquatic Ectoxicology in the Context of the Directive 91/414/EEC. SANCO/3268/2001 rev4 (Final) 2002.
3. EC Regulation (EC) No 1107/2009 of the European Parliament and of the Council of 21 October 2009 concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC. Official Journal of the European Communities 2009.
4. EPA U. Title 40-Protection of Environment. Part 158: Data Requirements for Registration. Code of Federal Regulations 2004, US Environment Protection Agency.
5. Hornsby A.G., Wauchope R.D., Herner A.E. Pesticide Properties in the Environment 1996, vol. 1. Springer Verlag, New York.
6. ICH International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Guidance on Nonclinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals M3(R2). Recommended for Adoption at Step 4 of the ICH Process on June 11 2009.
7. PSD Formulation Studies in Ecotoxicology: Guidance on the Need for Studies and their Use in Risk Assessment 2009, Pesticides Safety Directorate.
8. Robinson S., Delongeas J.L., Donald E., Dreher D., Festag M., Kervyn S., Lampo A., Nahas K., Nogues V., Ockert D., Quinn K., Old S., Pickersgill N., Somers K., Stark C., Stei P., Waterson L., Chapman K. A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development. Regulatory Toxicology and Pharmacology 2008, 50:345-352.
9. Schmuck R., Pflüger W., Grau R., Hollihn U., Fischer R. Comparison of short-term aquatic toxicity: formulation vs active ingredients of pesticides. Arch. Environ. Contam. Toxicol. 1994, 26:240-250.