Congenital cytomegalovirus infection: Treatment, sequelae and follow-up

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 23, Issue SUPPL. 3, 2010, Pages 45-48

  Lombardi, Giuseppina ^a   Garofoli, Francesca ^a   Stronati, Mauro ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

congenital infection; Cytomegalovirus; follow up; ganciclovir; valganciclovir

Indexed keywords

GANCICLOVIR; VALGANCICLOVIR; ANTIVIRUS AGENT;

ANEMIA; ANTIVIRAL ACTIVITY; BONE MARROW DEPRESSION; BRAIN CALCIFICATION; CENTRAL NERVOUS SYSTEM DISEASE; CEREBRAL PALSY; CEREBROSPINAL FLUID CIRCULATION DISORDER; CHORIORETINITIS; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL INFECTION; CYTOMEGALOVIRUS INFECTION; DOPPLER ECHOGRAPHY; DOSE RESPONSE; DRUG APPROVAL; DRUG BIOAVAILABILITY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FOLLOW UP; HEARING LOSS; HUMAN; INFECTION COMPLICATION; INFECTION CONTROL; LIVER TOXICITY; MAXIMUM PLASMA CONCENTRATION; MENTAL DEFICIENCY; MICROCEPHALY; NEPHROTOXICITY; NEUROIMAGING; NEUTROPENIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIMAL DRUG DOSE; PERCEPTION DEAFNESS; PRIORITY JOURNAL; PSYCHOMOTOR DISORDER; REVIEW; SEIZURE; THROMBOCYTOPENIA; TREATMENT DURATION; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS REPLICATION; VISUAL DISORDER; CHEMICALLY INDUCED DISORDER; CHILD; DEVELOPMENTAL DISORDER; NEWBORN; NEWBORN DISEASE;

ANTIVIRAL AGENTS; CHILD; CYTOMEGALOVIRUS INFECTIONS; DEVELOPMENTAL DISABILITIES; FOLLOW-UP STUDIES; GANCICLOVIR; HEARING LOSS, SENSORINEURAL; HUMANS; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES;

EID: 77957955871     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2010.506753     Document Type: Review

References (23)

1. Nassetta L, Kimberlin D, Whitley. Treatment of congenital cytomegalovirus infection: implications for future strategies. JAC Antiviral 2009;63:862-867.
2. Barbi M, Binda S, Caroppo S, Calvario A, Germinario C, Bozzi A, Tanzi ML, Veronesi L, Mura I, Piana A, et al. Multicity Italian study of congenital cytomegalovirus infection. Pediatr Infect Dis J 2006;25:156-159.
3. Coll O, Benoist G, Ville Y, Weisman LE, Botet F, Anceschi MM, Greenough A, Gibbs RS, Carbonell-Estrany X. Guidelines on CMV congenital infection. J Perinat Med. 2009;37: 433-445.
4. Schleiss MR. Congenital cytomegalovirus infection: update on management strategies. Curr treat opinions 2008;10:186-192.
5. Nigro G, Adler SP, La Torre R, Best AM. Congenital Cytomegalovirus Collaborating Group. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med. 2005;353:1350-1362.
6. Michaels MG. Treatment of congenital cytomegalovirus: where are we now? Expert Rev Anti Infect Ther 2007;5:441-448.
7. Oliver SE, Cloud GA, Sánchez PJ, Demmler GJ, Dankner W, Shelton M, Jacobs RF, Vaudry W, Pass RF, Soong SJ, Whitley RJ, Kimberlin DW. Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system. J Clin Virol 2009;4:S22-S26.
8. Galli L, Novelli A, Chiappini E Gervaso P, Cassetta MI, Fallani S, de Martino M. Valganciclovir for congenital CMV infection: a pilot study on plasma concentration in newborns and infants. Ped Infec Dis J 2007;26:451-453.
9. Kimberlin DW, Acosta EP, Sanchez PJ. Pharmacokinetic and Pharmacodynamic assessment of oral Valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. 2008; J Infect Dis 197:836-845.
10. Lombardi G, Garofoli F, Villani P, Tizzoni M, Angelini M, Cusato M, Bollani L, De Silvestri A, Regazzi M, Stronati M. Oral Valganciclovir treatment in newborns with symptomatic congenital cytomegalovirus infection. Eur J Clin Microbiol Infect Dis 2009;28:1465-1470.
11. Amir J, Wolf DG, Levy I. Treatment of symptomatic congenital cytomegalovirus infection with intravenous ganciclovir followed by long-term oral valganciclovir. Eur J Pediatr 2010;169:1061-1067. [Epub ahead of print].
12. Hilgendorff A, Daiminger A, Dangel V, Kreuder J, Geidel C, Reiss I, Enders G. Oral Valganciclovir treatment in a CMV congenital infected infant with sensorineural hearing loss (SNHL) first detected at 4 months of age. Klin Padiatr 2009;221:448-449.
13. Dollard SC, Grosse SD, Ross DS. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol 2007;17:355-363.
14. Pass RF, Fowler RB, Boppana SB, Britt WJ, Stagno S. Congenital cytomegalovirus infection following first trimester maternal infection: symtoms at birth and outcome. J Clin Virol 2006;35:216-220.
15. Lanari M, Lazzarotto T, Venturi V, Papa I, Gabrielli L, Guerra B Landini MP, Faldella G. Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns. Pediatrics 2002;117: e76-e83.
16. Arav-Boger R, Battaglia CA, Lazzarotto T, Gabrielli L, Zong JC, Hayward GS,Diener-West M, Landini MP. Cytomegalovirus (CMV)-encoded UL144 (truncated tumor necrosis factor receptor) and outcome of congenital CMV infection. J Infect Dis 2006;1944:64-73.
17. Fowler KB, Dahle AJ, Boppana SB, Pass RF. Newborn hearing screening: will children with hearing loss caused by congenital cytomegalovirus infection be missed? J Pediatr 1999;135:60-64.
18. Rivera LB, Boppana S, Fowler K, Britt WJ, Stagno S, Pass R. Predictors of hearing loss in children with symptomatic congenital cytomegalovirus infection. Pediatr 2002;110: 762-767.
19. Boppana S, Amos C, Britt W, Stagno S, Alford C, Pass R. Late onset and reactivation of chorioretinitis in children with congenital cytomegalovirus infection. Pediatr Infect Dis J 1994;13:1139-1142.
20. Ivarsson SA, Lernmark B, Svanberg L. Ten-year clinical, developmental, and intellectual follow-up of children with congenital cytomegalovirus infection without neurologic symptoms at one year of age. Pediatrics 1997;99:800-803.
21. Boppana SB, Fowler KB, Vaid Y, Hedlund G, Stagno S, Britt WJ, Pass RF. Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection. Pediatrics 1997;99:409-414.
22. Noyola DE., Demmler GJ., Nelson T, Griesser C, Williamson WD, Atkins JT, Rozelle J, Turcich M, Llorente AM, Sellers- Vinson S, et al. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Ped 2001;138:325-331.
23. De Vries LS, Verboon-Maciolek MA, Cowan FM, Groenendaal F. The role of cranial ultrasound and magnetic resonance imaging in the diagnosis of infections of the central nervous system. Early Hum Dev 2006;82:819-825.