Identification of a previously unrecognized promoter that drives expression of the UXP transcription unit in the human adenovirus type 5 genome

Journal of Virology

Volumn 84, Issue 21, 2010, Pages 11470-11478

  Ying, Baoling ^a   Tollefson, Ann E ^a   Wold, William S M ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT BINDING FACTOR; MESSENGER RNA; RIBONUCLEASE; U EXON PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS 5; ARTICLE; CODON; CONTROLLED STUDY; DNA TEMPLATE; GEL MOBILITY SHIFT ASSAY; GENOME; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; VIRUS IDENTIFICATION; CELL LINE; GENETIC TRANSCRIPTION; GENETICS; HUMAN ADENOVIRUS; TRANSCRIPTION INITIATION SITE; VIRUS GENOME;

ADENOVIRIDAE; HUMAN ADENOVIRUS TYPE 5;

ADENOVIRUSES, HUMAN; CELL LINE; GENOME, VIRAL; HUMANS; PROMOTER REGIONS, GENETIC; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

EID: 77957950049     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01338-10     Document Type: Article

References (45)

1. Akusjarvi, G. 2008. Temporal regulation of adenovirus major late alternative RNA splicing. Front. Biosci. 13:5006-5015.
2. Ali, H., G. LeRoy, G. Bridge, and S. J. Flint. 2007. The adenovirus L4 33-kilodalton protein binds to intragenic sequences of the major late promoter required for late-phase-specific stimulation of transcription. J. Virol. 81:1327-1338.
3. Berk, A. J. 2005. Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Oncogene 24:7673-7685.
4. Berk, A. J. 2007. Adenoviridae: the viruses and their replication, p. 2355-2394. In D. M. Knipe and P. M. Howley (ed.), Fields virology. Lippincott, Williams, & Wilkins, Philadelphia, PA.
5. Bhat, G., L. SivaRaman, S. Murthy, P. Domer, and B. Thimmappaya. 1987. In vivo identification of multiple promoter domains of adenovirus EIIA-late promoter. EMBO J. 6:2045-2052.
6. Blackford, A. N., and R. J. Grand. 2009. Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation. J. Virol. 83:4000-4012.
7. Bucher, P. 1990. Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. J. Mol. Biol. 212:563-578.
8. Carcamo, J., L. Buckbinder, and D. Reinberg. 1991. The initiator directs the assembly of a transcription factor IID-dependent transcription complex. Proc. Natl. Acad. Sci. U. S. A. 88:8052-8056.
9. Chen, H., and S. J. Flint. 1992. Mutational analysis of the adenovirus 2 IVa2 initiator and downstream elements. J. Biol. Chem. 267:25457-25465.
10. Chow, L. T., T. R. Broker, and J. B. Lewis. 1979. Complex splicing patterns of RNAs from the early regions of adenovirus-2. J. Mol. Biol. 134:265-303.
11. Crossland, L. D., and H. J. Raskas. 1983. Identification of adenovirus genes that require template replication for expression. J. Virol. 46:737-748.
12. Dobner, T., and J. Kzhyshkowska. 2001. Nuclear export of adenovirus RNA. Curr. Top. Microbiol. Immunol. 259:25-54.
13. Fessler, S. P., F. Delgado-Lopez, and M. S. Horwitz. 2004. Mechanisms of E3 modulation of immune and inflammatory responses. Curr. Top. Microbiol. Immunol. 273:113-135.
14. Goding, C. R., S. M. Temperley, and F. Fisher. 1987. Multiple transcription factors interact with the adenovirus-2 EII-late promoter: evidence for a novel CCAAT recognition factor. Nucleic Acids Res. 15:7761-7780.
15. Holm, P. S., S. Bergmann, K. Jurchott, H. Lage, K. Brand, A. Ladhoff, K. Mantwill, D. T. Curiel, M. Dobbelstein, M. Dietel, B. Gansbacher, and H. D. Royer. 2002. YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter. J. Biol. Chem. 277:10427-10434.
16. Horwitz, M. S. 2004. Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins. J. Gen. Med. 6(Suppl. 1):S172-S183.
17. Huang, W., J. Kiefer, D. Whalen, and S. J. Flint. 2003. DNA synthesis-dependent relief of repression of transcription from the adenovirus type 2 IVa(2) promoter by a cellular protein. Virology 314:394-402.
18. Iftode, C., and S. J. Flint. 2004. Viral DNA synthesis-dependent titration of a cellular repressor activates transcription of the human adenovirus type 2 IVa2 gene. Proc. Natl. Acad. Sci. U. S. A. 101:17831-17836.
19. Leppard, K. N. 1997. E4 gene function in adenovirus, adenovirus vector and adeno-associated virus infections. J. Gen. Virol. 78:2131-2138.
20. Lichtenstein, D. L., K. Toth, K. Doronin, A. E. Tollefson, and W. S. M. Wold. 2004. Functions and mechanisms of action of the adenovirus E3 proteins. Int. Rev. Immunol. 23:75-111.
21. Lu, H., M. D. Reach, E. Minaya, and C. S. Young. 1997. The initiator element of the adenovirus major late promoter has an important role in transcription initiation in vivo. J. Virol. 71:102-109.
22. Lutz, P., M. Rosa-Calatrava, and C. Kedinger. 1997. The product of the adenovirus intermediate gene IX is a transcriptional activator. J. Virol. 71:5102-5109. (Pubitemid 27258181)
23. Mantovani, R. 1998. A survey of 178 NF-Y binding CCAAT boxes. Nucleic Acids Res. 26:1135-1143.
24. Matsui, T., M. Murayama, and T. Mita. 1986. Adenovirus 2 peptide IX gene is expressed only on replicated DNA molecules. Mol. Cell. Biol. 6:4149-4154.
25. Matys, V., E. Fricke, R. Geffers, E. Gossling, M. Haubrock, R. Hehl, K. Hornischer, D. Karas, A. E. Kel, O. V. Kel-Margoulis, D. U. Kloos, S. Land, B. Lewicki-Potapov, H. Michael, R. Munch, I. Reuter, S. Rotert, H. Saxel, M. Scheer, S. Thiele, and E. Wingender. 2003. TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res. 31:374-378.
26. Morris, S. J., and K. N. Leppard. 2009. Adenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression. J. Virol. 83:3049-3058.
27. Morris, S. J., G. E. Scott, and K. N. Leppard. 2010. Adenovirus late phase infection is controlled by a novel L4 promoter. J. Virol. 84:7096-7104.
28. Natarajan, V., and N. P. Salzman. 1985. Cis and trans activation of adenovirus IVa2 gene transcription. Nucleic Acids Res. 13:4067-4083.
29. Pardo-Mateos, A., and C. S. Young. 2004. Adenovirus IVa2 protein plays an important role in transcription from the major late promoter in vivo. Virology 327:50-59.
30. Rosa-Calatrava, M., L. Grave, F. Puvion-Dutilleul, B. Chatton, and C. Kedinger. 2001. Functional analysis of adenovirus protein IX identifies domains involved in capsid stability, transcriptional activity, and nuclear reorganization. J. Virol. 75:7131-7141. (Pubitemid 32641601)
31. Smale, S. T. 1997. Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes. Biochim. Biophys. Acta 1351:73-88.
32. Smale, S. T., and D. Baltimore. 1989. The "initiator" as a transcription control element. Cell 57:103-113.
33. Smale, S. T., and J. T. Kadonaga. 2003. The RNA polymerase II core promoter. Annu. Rev. Biochem. 72:449-479.
34. Song, B., and C. S. Young. 1998. Functional analysis of the CAAT box in the major late promoter of the subgroup C human adenoviruses. J. Virol. 72:3213-3220.
35. Suzuki, Y., H. Taira, T. Tsunoda, J. Mizushima-Sugano, J. Sese, H. Hata, T. Ota, T. Isogai, T. Tanaka, S. Morishita, K. Okubo, Y. Sakaki, Y. Nakamura, A. Suyama, and S. Sugano. 2001. Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep. 2:388-393. (Pubitemid 32509953)
36. Symington, J. S., L. A. Lucher, K. H. Brackmann, A. Virtanen, U. Pettersson, and M. Green. 1986. Biosynthesis of adenovirus type 2 i-leader protein. J. Virol. 57:848-856.
37. Thomas, G. P., and M. B. Mathews. 1980. DNA replication and the early to late transition in adenovirus infection. Cell 22:523-533.
38. Tollefson, A. E., M. Kuppuswamy, E. V. Shashkova, K. Doronin, and W. S. M. Wold. 2007. Preparation and titration of CsCl-banded adenovirus stocks. Methods Mol. Med. 130:223-235.
39. Tollefson, A. E., A. Scaria, S. K. Saha, and W. S. M. Wold. 1992. The 11,600-MW protein encoded by region E3 of adenovirus is expressed early but is greatly amplified at late stages of infection. J. Virol. 66:3633-3642.
40. Tollefson, A. E., B. Ying, K. Doronin, P. D. Sidor, and W. S. Wold. 2007. Identification of a new human adenovirus protein encoded by a novel late l-strand transcription unit. J. Virol. 81:12918-12926.
41. Tribouley, C., P. Lutz, A. Staub, and C. Kedinger. 1994. The product of the adenovirus intermediate gene IVa2 is a transcriptional activator of the major late promoter. J. Virol. 68:4450-4457.
42. Weitzman, M. D. 2005. Functions of the adenovirus E4 proteins and their impact on viral vectors. Front. Biosci. 10:1106-1117.
43. Weitzman, M. D., and D. A. Ornelles. 2005. Inactivating intracellular antiviral responses during adenovirus infection. Oncogene 24:7686-7696.
44. Windheim, M., A. Hilgendorf, and H. G. Burgert. 2004. Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways. Curr. Top. Microbiol. Immunol. 273:29-85.
45. Ying, B., K. Toth, J. F. Spencer, J. Meyer, A. E. Tollefson, D. Patra, D. Dhar, E. V. Shashkova, M. Kuppuswamy, K. Doronin, M. A. Thomas, L. A. Zumstein, W. S. M. Wold, and D. L. Lichtenstein. 2009. INGN 007, an oncolytic adenovirus vector, replicates in Syrian hamsters but not mice: comparison of biodistribution studies. Cancer Gene Ther. 16:625-637.