Selection at linked sites shapes heritable phenotypic variation in C. elegans

Science

Volumn 330, Issue 6002, 2010, Pages 372-376

  Rockman, Matthew V ^a,b   Skrovanek, Sonja S ^b   Kruglyak, Leonid ^b  

^a NEW YORK UNIVERSITY   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFFECTIVE POPULATION SIZE; GENETIC DRIFT; GENOMICS; HERITABILITY; LIFE HISTORY TRAIT; MUTATION; NATURAL SELECTION; NEMATODE; PHENOTYPE;

ARTICLE; CAENORHABDITIS ELEGANS; EFFECTIVE POPULATION SIZE; GENE MUTATION; GENETIC SELECTION; GENETIC TRAIT; GENETIC VARIABILITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; ALLELE; ANIMAL; BIOLOGICAL MODEL; CHROMOSOME; CHROMOSOME MAP; CROSS BREEDING; DNA MICROARRAY; GENE; GENE EXPRESSION; GENETIC RECOMBINATION; GENETICS; MOLECULAR EVOLUTION; MUTATION; PHYSIOLOGY; POPULATION DENSITY; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL;

CAENORHABDITIS ELEGANS;

ALLELES; ANIMALS; CAENORHABDITIS ELEGANS; CHROMOSOME MAPPING; CHROMOSOMES; CROSSES, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION; GENES, HELMINTH; GENETIC VARIATION; LOGISTIC MODELS; MODELS, GENETIC; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION DENSITY; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; RECOMBINATION, GENETIC; SELECTION, GENETIC;

EID: 77957942349     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1194208     Document Type: Article

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33. We thank E. Andersen, A. Chang, J. Gerke, R. Ghosh, D. Gresham, M. Hahn, A. Paaby, D. Pollard, H. Seidel, and J. Shapiro for comments on the manuscript. We thank the Caenorhabditis Genetics Center, funded by the NIH National Center for Research Resources, for strains. Our work was supported by the NIH (grants R01 HG004321 to L.K., R01 GM089972 to M.V.R., and P50 GM071508 to the Lewis-Sigler Institute), a Jane Coffin Childs Fellowship (M.V.R.), an Ellison Foundation New Scholar Award (M.V.R.), and a James S. McDonnell Foundation Centennial Fellowship (L.K.). L.K. is an investigator of the Howard Hughes Medical Institute. Microarray data have been deposited at the Gene Expression Omnibus with accession number GSE23857.