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Volumn 6, Issue 9, 2010, Pages 1387-1394

The trifunctional antibody catumaxomab in treatment of malignant ascites and peritoneal carcinomatosis

Author keywords

ascites; bispecific; catumaxomab; EpCAM; intraperitoneal immunotherapy; peritoneal carcinomatosis; trifunctional antibody

Indexed keywords

CATUMAXOMAB; EPITHELIAL CELL ADHESION MOLECULE;

EID: 77957941980     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.10.111     Document Type: Review
Times cited : (14)

References (38)
  • 1
    • 0021875369 scopus 로고
    • Extrapelvic colon - Areas of failure in a reoperation series: Implications for adjuvant therapy
    • Gunderson Ll, Sosin H, Levitt S: Extrapelvic colon - areas of failure in a reoperation series: implications for adjuvant therapy. Int. J. Radiat. Oncol. Biol. Phys. 11(4), 731-741 (1985).
    • (1985) Int. J. Radiat. Oncol. Biol. Phys. , vol.11 , Issue.4 , pp. 731-741
    • Gunderson, L.I.1    Sosin, H.2    Levitt, S.3
  • 2
    • 31844444755 scopus 로고    scopus 로고
    • Peritoneal carcinomatosis of colorectal origin: Incidence and current treatment strategies
    • Koppe MJ, Boerman OC, Oyen WJ, Bleichrodt RP: Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies. Ann. Surg. 243(2), 212-222 (2006).
    • (2006) Ann. Surg. , vol.243 , Issue.2 , pp. 212-222
    • Koppe, M.J.1    Boerman, O.C.2    Oyen, W.J.3    Bleichrodt, R.P.4
  • 3
    • 0024343824 scopus 로고
    • Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer
    • Sugarbaker PH, Cunliffe WJ, Belliveau J et al.: Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer. Semin. Oncol. 16(4 Suppl. 6), 83-97 (1989).
    • (1989) Semin. Oncol. , vol.16 , Issue.4-6 , pp. 83-97
    • Sugarbaker, P.H.1    Cunliffe, W.J.2    Belliveau, J.3
  • 4
    • 18744400770 scopus 로고    scopus 로고
    • Peritoneal carcinomatosis from colorectal cancer
    • Jayne Dg, Fook S, Loi C, Seow-Choen F: Peritoneal carcinomatosis from colorectal cancer. Br. J. Surg. 89(12), 1545-1550 (2002).
    • (2002) Br. J. Surg. , vol.89 , Issue.12 , pp. 1545-1550
    • Jayne, D.G.1    Fook, S.2    Loi, C.3    Seow-Choen, F.4
  • 5
    • 0029901208 scopus 로고    scopus 로고
    • Malignant ascites: A 2-year review from a teaching hospital
    • Parsons SL, Lang MW, Steele RJ: Malignant ascites: a 2-year review from a teaching hospital. Eur. J. Surg. Oncol. 22(3), 237-239 (1996).
    • (1996) Eur. J. Surg. Oncol. , vol.22 , Issue.3 , pp. 237-239
    • Parsons, S.L.1    Lang, M.W.2    Steele, R.J.3
  • 6
    • 0034650278 scopus 로고    scopus 로고
    • Peritoneal carcinomatosis from nongynecologic malignancies: Results of the evocape 1 multicentric prospective study
    • Sadeghi B, Arvieux C, Glehen O et al.: Peritoneal carcinomatosis from nongynecologic malignancies: results of the evocape 1 multicentric prospective study. Cancer 88(2), 358-363 (2000).
    • (2000) Cancer , vol.88 , Issue.2 , pp. 358-363
    • Sadeghi, B.1    Arvieux, C.2    Glehen, O.3
  • 7
    • 36849047917 scopus 로고    scopus 로고
    • Systemic treatment of peritoneal metastases
    • Arnold D, Lordick F: Systemic treatment of peritoneal metastases. Chirurg 78(12), 1117-1122 (2007).
    • (2007) Chirurg , vol.78 , Issue.12 , pp. 1117-1122
    • Arnold, D.1    Lordick, F.2
  • 8
    • 0024530870 scopus 로고
    • Peritoneal carcinomatosis in nongynecologic malignancy a prospective study of prognostic factors
    • Chu DZ, Lang NP, Thompson C, Osteen PK, Westbrook KC: Peritoneal carcinomatosis in nongynecologic malignancy. A prospective study of prognostic factors. Cancer 63(2), 364-367 (1989).
    • (1989) Cancer , vol.63 , Issue.2 , pp. 364-367
    • Chu, D.Z.1    Lang, N.P.2    Thompson, C.3    Osteen, P.K.4    Westbrook, K.C.5
  • 9
    • 0142087625 scopus 로고    scopus 로고
    • Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer
    • Verwaal VJ, Van Ruth S, De Bree E et al.: Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J. Clin. Oncol. 21(20), 3737-3743 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , Issue.20 , pp. 3737-3743
    • Verwaal, V.J.1    Van Ruth, S.2    De Bree, E.3
  • 10
    • 73949137339 scopus 로고    scopus 로고
    • Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: Retrospective analysis of 523 patients from a multicentric french study
    • Elias D, Gilly F, Boutitie F et al.: Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric french study. J. Clin. Oncol. 28(1), 63-68 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.1 , pp. 63-68
    • Elias, D.1    Gilly, F.2    Boutitie, F.3
  • 11
    • 77956341012 scopus 로고    scopus 로고
    • Peritoneal carcinomatosis from gastric cancer: A multi-institutional study of 159 patients treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy
    • 10.1245/s10434-010-1039-7 Epub ahead of print
    • Glehen O, Gilly FN, Arvieux C et al.: Peritoneal carcinomatosis from gastric cancer: a multi-institutional study of 159 patients treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy. Ann. Surg. Oncol. DOI 10.1245/s10434-010-1039-7 (2010) (Epub ahead of print).
    • (2010) Ann. Surg. Oncol.
    • Glehen, O.1    Gilly, F.N.2    Arvieux, C.3
  • 12
    • 33645865266 scopus 로고    scopus 로고
    • Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy
    • Sugarbaker PH, Alderman R, Edwards G et al.: Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy. Ann. Surg. Oncol. 13(5), 635-644 (2006).
    • (2006) Ann. Surg. Oncol. , vol.13 , Issue.5 , pp. 635-644
    • Sugarbaker, P.H.1    Alderman, R.2    Edwards, G.3
  • 14
    • 39149130004 scopus 로고    scopus 로고
    • Therapeutic window of mus110 a single-chain antibody construct bispecific for murine epcam and murine CD3
    • Amann M, Brischwein K, Lutterbuese P et al.: Therapeutic window of mus110, a single-chain antibody construct bispecific for murine epcam and murine CD3. Cancer Res. 68(1), 143-151 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.1 , pp. 143-151
    • Amann, M.1    Brischwein, K.2    Lutterbuese, P.3
  • 15
    • 1642580506 scopus 로고    scopus 로고
    • Frequent EpCam protein expression in human carcinomas
    • Went PT, Lugli A, Meier S et al.: Frequent EpCam protein expression in human carcinomas. Hum. Pathol. 35(1), 122-128 (2004).
    • (2004) Hum. Pathol. , vol.35 , Issue.1 , pp. 122-128
    • Went, P.T.1    Lugli, A.2    Meier, S.3
  • 16
    • 30644472381 scopus 로고    scopus 로고
    • Frequent high-level expression of the immunotherapeutic target Ep-Cam in colon stomach prostate and lung cancers
    • Went P, Vasei M, Bubendorf L et al.: Frequent high-level expression of the immunotherapeutic target Ep-Cam in colon, stomach, prostate and lung cancers. Br. J. Cancer 94(1), 128-135 (2006).
    • (2006) Br. J. Cancer , vol.94 , Issue.1 , pp. 128-135
    • Went, P.1    Vasei, M.2    Bubendorf, L.3
  • 17
    • 4143065769 scopus 로고    scopus 로고
    • The carcinoma-associated antigen EpCam upregulates c-myc and induces cell proliferation
    • Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O: The carcinoma-associated antigen EpCam upregulates c-myc and induces cell proliferation. Oncogene 23(34), 5748-5758 (2004).
    • (2004) Oncogene , vol.23 , Issue.34 , pp. 5748-5758
    • Munz, M.1    Kieu, C.2    Mack, B.3    Schmitt, B.4    Zeidler, R.5    Gires, O.6
  • 18
    • 4143074922 scopus 로고    scopus 로고
    • EpCam is overexpressed in breast cancer and is a potential target for breast cancer gene therapy
    • Osta Wa, Chen Y, Mikhitarian K et al.: EpCam is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 64(16), 5818-5824 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.16 , pp. 5818-5824
    • Osta, W.A.1    Chen, Y.2    Mikhitarian, K.3
  • 19
    • 77952144984 scopus 로고    scopus 로고
    • Adecatumumab: An anti-EpCam monoclonal antibody, from the bench to the bedside
    • Kurtz Je, Dufour P: Adecatumumab: an anti-EpCam monoclonal antibody, from the bench to the bedside. Expert Opin. Biol. Ther. 10(6), 951-958 (2010).
    • (2010) Expert Opin. Biol. Ther. , vol.10 , Issue.6 , pp. 951-958
    • Kurtz, J.E.1    Dufour, P.2
  • 20
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517), 495-497 (1975).
    • (1975) Nature , vol.256 , Issue.5517 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 21
    • 0036671332 scopus 로고    scopus 로고
    • Bispecific antibodies targeting cancer cells
    • Peipp M, Valerius T: Bispecific antibodies targeting cancer cells. Biochem. Soc. Trans. 30(4), 507-511 (2002).
    • (2002) Biochem. Soc. Trans. , vol.30 , Issue.4 , pp. 507-511
    • Peipp, M.1    Valerius, T.2
  • 22
    • 0042326327 scopus 로고    scopus 로고
    • Bispecific antibodies for polyclonal T-cell engagement
    • Baeuerle PA, Kufer P, Lutterbuse R: Bispecific antibodies for polyclonal T-cell engagement. Curr. Opin. Mol. Ther. 5(4), 413-419 (2003).
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , Issue.4 , pp. 413-419
    • Baeuerle, P.A.1    Kufer, P.2    Lutterbuse, R.3
  • 23
    • 64649103924 scopus 로고    scopus 로고
    • Mode of cytotoxic action of T cell-engaging bite antibody MT110
    • Haas C, Krinner E, Brischwein K et al.: Mode of cytotoxic action of T cell-engaging bite antibody MT110. Immunobiology 214(6), 441-453 (2009).
    • (2009) Immunobiology , vol.214 , Issue.6 , pp. 441-453
    • Haas, C.1    Krinner, E.2    Brischwein, K.3
  • 25
    • 0029063312 scopus 로고
    • Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas implications for a single-step purification of bispecific antibodies
    • Lindhofer H, Mocikat R, Steipe B, Thierfelder S: Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. J. Immunol. 155(1), 219-225 (1995).
    • (1995) J. Immunol. , vol.155 , Issue.1 , pp. 219-225
    • Lindhofer, H.1    Mocikat, R.2    Steipe, B.3    Thierfelder, S.4
  • 26
    • 0029858009 scopus 로고    scopus 로고
    • Bispecific antibodies target operationally tumor-specific antigens in two leukemia relapse models
    • Lindhofer H, Menzel H, Gunther W, Hultner L, Thierfelder S: Bispecific antibodies target operationally tumor-specific antigens in two leukemia relapse models. Blood 88(12), 4651-4658 (1996).
    • (1996) Blood , vol.88 , Issue.12 , pp. 4651-4658
    • Lindhofer, H.1    Menzel, H.2    Gunther, W.3    Hultner, L.4    Thierfelder, S.5
  • 27
    • 0035889129 scopus 로고    scopus 로고
    • Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody
    • Ruf P, Lindhofer H: Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody. Blood 98(8), 2526-2534 (2001).
    • (2001) Blood , vol.98 , Issue.8 , pp. 2526-2534
    • Ruf, P.1    Lindhofer, H.2
  • 28
    • 0035528821 scopus 로고    scopus 로고
    • TNFa contributes to the antitumor activity of a bispecific trifunctional antibody
    • Zeidler R, Mayer A, Gires O et al.: TNFa contributes to the antitumor activity of a bispecific, trifunctional antibody. Anticancer Res. 21(5), 3499-3503 (2001).
    • (2001) Anticancer Res. , vol.21 , Issue.5 , pp. 3499-3503
    • Zeidler, R.1    Mayer, A.2    Gires, O.3
  • 29
    • 0034051390 scopus 로고    scopus 로고
    • The fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells
    • Zeidler R, Mysliwietz J, Csanady M et al.: The fc-region of a new class of intact bispecific antibody mediates activation of accessory cells and NK cells and induces direct phagocytosis of tumour cells. Br. J. Cancer 83(2), 261-266 (2000).
    • (2000) Br. J. Cancer , vol.83 , Issue.2 , pp. 261-266
    • Zeidler, R.1    Mysliwietz, J.2    Csanady, M.3
  • 30
    • 0033178740 scopus 로고    scopus 로고
    • Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing
    • Zeidler R, Reisbach G, Wollenberg B et al.: Simultaneous activation of T cells and accessory cells by a new class of intact bispecific antibody results in efficient tumor cell killing. J. Immunol. 163(3), 1246-1252 (1999).
    • (1999) J. Immunol. , vol.163 , Issue.3 , pp. 1246-1252
    • Zeidler, R.1    Reisbach, G.2    Wollenberg, B.3
  • 32
    • 69749117809 scopus 로고    scopus 로고
    • Intraperitoneal immunotherapy to prevent peritoneal carcinomatosis in patients with advanced gastrointestinal malignancies
    • Strohlein MA, Heiss MM: Intraperitoneal immunotherapy to prevent peritoneal carcinomatosis in patients with advanced gastrointestinal malignancies. J. Surg. Oncol. 100(4), 329-330 (2009).
    • (2009) J. Surg. Oncol. , vol.100 , Issue.4 , pp. 329-330
    • Strohlein, M.A.1    Heiss, M.M.2
  • 33
    • 57749187042 scopus 로고    scopus 로고
    • Immunotherapy of peritoneal carcinomatosis
    • Strohlein MA, Heiss MM: Immunotherapy of peritoneal carcinomatosis. Cancer Treat. Res. 134, 483-491 (2007).
    • (2007) Cancer Treat. Res. , vol.134 , pp. 483-491
    • Strohlein, M.A.1    Heiss, M.M.2
  • 34
    • 26444592251 scopus 로고    scopus 로고
    • Immunotherapy of malignant ascites with trifunctional antibodies
    • Heiss MM, Strohlein MA, Jager M et al.: Immunotherapy of malignant ascites with trifunctional antibodies. Int. J. Cancer 117(3), 435-443 (2005).
    • (2005) Int. J. Cancer , vol.117 , Issue.3 , pp. 435-443
    • Heiss, M.M.1    Strohlein, M.A.2    Jager, M.3
  • 35
    • 34447132202 scopus 로고    scopus 로고
    • Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCam X anti-CD3 antibody: A Phase I/II study
    • Burges A, Wimberger P, Kumper C et al.: Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCam X anti-CD3 antibody: a Phase I/II study. Clin. Cancer Res. 13(13), 3899-3905 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.13 , pp. 3899-3905
    • Burges, A.1    Wimberger, P.2    Kumper, C.3
  • 36
    • 77954676136 scopus 로고    scopus 로고
    • The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized Phase II/III trial
    • 10.1002/ijc.25423 Epub ahead of print
    • Heiss MM, Murawa P, Koralewski P et al.: The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: results of a prospective randomized Phase II/III trial. Int. J. Cancer. DOI 10.1002/ijc.25423 (2010) (Epub ahead of print).
    • (2010) Int. J. Cancer.
    • Heiss, M.M.1    Murawa, P.2    Koralewski, P.3
  • 37
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab anti-EpCAM x anti-CD3 as a targeted cancer immunotherapy
    • 10.1016/j.ctrv.2010.03.001 Epub ahead of print
    • Seimetz D, Lindhofer H, Bokemeyer C: Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treat. Rev. DOI 10.1016/j.ctrv.2010.03.001 (2010) (Epub ahead of print).
    • (2010) Cancer Treat. Rev.
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 38
    • 76149114375 scopus 로고    scopus 로고
    • Elimination of cancer stem cells CD133+/EpCAM+ from malignant ascites by the trifunctional antibody catumaxomab: Results from a pivotal Phase II/ III study
    • Abstract 3014
    • Lindhofer H, Schoberth A, Pelster D, Hess J, Herold J, Jäger M: Elimination of cancer stem cells (CD133+/EpCAM+) from malignant ascites by the trifunctional antibody catumaxomab: results from a pivotal Phase II/ III study. J. Clin. Oncol. 27(S15) (2009) (Abstract 3014).
    • (2009) J. Clin. Oncol. , vol.27
    • Lindhofer, H.1    Schoberth, A.2    Pelster, D.3    Hess, J.4    Herold, J.5    Jäger, M.6


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