Novel genetic marker in TGFB2 gene associated with expression of TGF-β2 in leukocyte and SLE susceptibility

Asian Biomedicine

Volumn 4, Issue 2, 2010, Pages 263-269

  Hirankarn, Nattiya ^a   Hemwijit, Krongkamol ^a   Benjachat, Thitima ^a   Avihingsanon, Yingyos ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Gene polymorphism; SLE; TGFB2; Thai population

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA2;

ARTICLE; CHROMOSOME; CHROMOSOME 1Q41; CONTROLLED STUDY; DNA POLYMORPHISM; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNOREGULATION; INTRON; LEUKOCYTE; MAJOR CLINICAL STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 77957940978     PISSN: 19057415     EISSN: None     Source Type: Journal    
DOI: 10.2478/abm-2010-0033     Document Type: Article

References (17)

1. Tsao BP. Update on human systemic lupus erythematosus genetics. Curr Opin Rheumatol. 2004; 16:513-21.
2. Zhang H, Yang P, Zhou H, Meng Q, Huang X: Involvement of Foxp3-expressing CD4+ CD25+ regulatory T cells in the development of tolerance induced by transforming growth factor-beta2-treated antigen-presenting cells. Immunology. 2008; 124: 304-14.
3. Namba K, Kitaichi N, Nishida T, Taylor AW. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming growth factor-beta2. J Leukoc Biol. 2002; 72:946-52.
4. Alansari A, Hajeer A, Teh LS, Bayat A, Mysercough A, Gul A, et al. Transforming growth factor-12 polymorphism and systemic lupus erythematosus. J Rheumatol. 2002; 29:1189-91.
5. Tsao BP, Cantor RM, Grossman JM, Shen N, Teophilov NT, Wallace DJ, et al. PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus. J Clin Invest. 1999; 103:1135-40.
6. Tocharoentanaphol C, Promso S, Zelenika D, Lowhnoo T, Tongsima S, Sura T, et al. Evaluation of resequencing on number of tag SNPs of 13 atherosclerosis-related genes in Thai population. J Hum Genet. 2008; 53:74-86.
7. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988; 16:1215.
8. Avihingsanon Y, Phumesin P, Benjachat T, Akkasilpa S, Kittikowit V, Praditpornsilpa K, et al. Measurement of urinary chemokine and growth factor messenger RNAs: a noninvasive monitoring in lupus nephritis. Kidney Int. 2006; 69:747-53.
9. Li B, Hartono C, Ding R, Sharma VK, Ramaswamy R, Qian B, et al. Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. N Engl J Med. 2001; 344:947-54.
10. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001; 25: 402-8.
11. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007; 81:559-75.
12. Alansari A, Hajeer AH, Bayat A, Eyre S, Carthy D, Ollier WE. Two novel polymorphisms in the human transforming growth factor beta 2 gene. Genes Immun. 2001; 2:295-6.
13. Barath S, Aleksza M, Tarr T, Sipka S, Szegedi G, Kiss E. Measurement of natural (CD4+CD25high) and inducible (CD4+IL-10+) regulatory T cells in patients with systemic lupus erythematosus. Lupus. 2007; 16: 489-96.
14. Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol. 2005; 175:8392-400.
15. Lee JH, Wang LC, Lin YT, Yang YH, Lin DT, Chiang BL. Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Immunology. 2006; 117:280-6.
16. Alvarado-Sanchez B, Hernandez-Castro B, Portales-Perez D, Baranda L, Layseca-Espinosa E, Abud-Mendoza C, et al. Regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun. 2006; 27:110-8.
17. Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol. 2007; 178:2579-88.