Mass transport in a microchannel enzyme reactor with a porous wall: Hydrodynamic modeling and applications

Biochemical Engineering Journal

Volumn 52, Issue 2-3, 2010, Pages 227-235

  Chen, Xiao Bing ^a   Sui, Yi ^a   Cheng, Yong Pan ^a   Lee, Heow Pueh ^a   Yu, Peng ^a   Winoto, S H ^a   Low, Hong Tong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Damkohler number; Mass transfer; Microchannel enzyme reactor; Porous wall

Indexed keywords

AXIAL DISTANCE; DAMKOHLER NUMBER; DISTANCE PARAMETER; DOMAIN APPROACH; ENZYME REACTORS; FIRST-ORDER; FLUID CONVECTION; FLUID REGIONS; HYDRODYNAMIC MODELING; MASS TRANSPORT; OR FLUXES; POROUS WALLS; REACTOR EFFICIENCY; TWO PARAMETER; TWO-DIMENSIONAL FLOW;

FLUIDS; MASS TRANSFER; MICROCHANNELS;

ENZYMES;

SILICON;

ARTICLE; CONCENTRATION (PARAMETERS); DAMKOHLER NUMBER; ENZYME REACTOR; FLOW; GEOMETRY; HYDRODYNAMICS; MATHEMATICAL MODEL; MICROCHANNEL ENZYME REACTOR; POROSITY; PRIORITY JOURNAL;

EID: 77957938680     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2010.08.015     Document Type: Article

References (26)

1. Miyazaki M., Maeda H. Microchannel enzyme reactors and their applications for processing. Trends Biotechnol. 2006, 24(10):463-470.
2. Urban P.L., Goodall D.M., Bruce N.C. Enzymatic microreactors in chemical analysis and kinetic studies. Biotechnol. Adv. 2006, 24(1):42-57.
3. Drott J., Lindstrom K., Rosengren L., Laurell T. Porous silicon as the carrier matrix in microstructured enzyme reactors yielding high enzyme activities. J. Micromech. Microeng. 1997, 7(1):14-23.
4. Drott J., Rosengren L., Lindstrom K., Laurell T. Porous silicon carrier matrices in micro enzyme reactors-influence of matrix depth. Mikrochim. Acta 1999, 131:115-120.
5. Melander C., Tüting W., Bengtsson M., Laurell T., Mischnick P., Gorton L. Hydrolysis of maltoheptaose in flow through silicon wafer microreactors containing immobilised α-amylase and glycoamylase. Starch-Stärke 2006, 58:231-242.
6. Bhatia S., Long W.S., Kamaruddin A.H. Enzymatic membrane reactor for the kinetic resolution of racemic ibuprofen ester: modeling and experimental studies. Chem. Eng. Sci. 2004, 59(22-23):5061-5068.
7. Tmej F., Limbergova Z., Hasal P. Modelling and optimisation of enzymatic separating micro-reactor. Bioprocess Biosyst. Eng. 2005, 28(2):123-130.
8. Horta A., Alvarez J.R., Luque S. Analysis of the transient response of a CSTR containing immobilized enzyme particles-Part I. Model development and analysis of the influence of operating conditions and process parameters. Biochem. Eng. J. 2007, 33(1):72-87.
9. Al-Muftah A.E., Abu-Reesh I.M. Effects of simultaneous internal and external mass transfer and product inhibition on immobilized enzyme-catalyzed reactor. Biochem. Eng. J. 2005, 27(2):167-178.
10. Zeng Y., Lee T.S., Yu P., Low H.T. Mass transport and shear stress in a microchannel bioreactor: numerical simulation and dynamic similarity. J. Biomech. Eng. 2006, 128:185-193.
11. Zeng Y., Lee T.S., Yu P., Low H.T. Numerical simulation on mass transport in a microchannel bioreactor for co-culture applications. J. Biomech. Eng. 2007, 129:365-373.
12. Zeng Y., Lee T.S., Yu P., Low H.T. Numerical simulation of mass transport in a microchannel bioreactor with cell micropatterning. J. Biomech. Eng. 2008, 130:1883-1900.
13. Chen X.B., Sui Y., Lee H.P., Bai H.X., Yu P., Winoto S.H., Low H.T. Mass transport in a microchannel bioreactor with a porous wall. J. Biomech. Eng. 2010, 132(6):061001. 10.1115/1.4001044.
14. Chen X.B., Yu P., Winoto S.H., Low H.T. A numerical method for forced convection in porous and homogenous fluid domains coupled at interface by stress jump. Int. J. Numer. Methods Fluids 2008, 56:1705-1729.
15. Chen X.B., Yu P., Winoto S.H., Low H.T. Forced convection over a backward facing step with a porous floor segment. Numer. Heat Transfer A: Appl. 2008, 53(11):1211-1230.
16. Michael L.S., Fikret K. Bioprocess Engineering: Basic Concepts 1992, Prentice-Hall, Englewood Cliffs, NJ.
17. Chow D.C., Wenning L.A., Miller W.M., Papoutsakis E.T. Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model. Biophys. J. 2001, 81:675-684.
18. Chow D.C., Wenning L.A., Miller W.M., Papoutsakis E.T. Modeling pO2 distributions in the bone marrow hematopoietic compartment. II. Modified Krogh's models. Biophys. J. 2001, 81:685-696.
19. Chen X.B., Yu P., Sui Y., Winoto S.H., Low H.T. Natural convection in a cavity filled with porous layers on the top and bottom walls. Transport Porous Media 2009, 78:259-276.
20. Ochoa-Tapia J.A., Whitaker S. Momentum jump condition at the boundary between a porous medium and a homogeneous fluid: inertial effect. J. Porous Media 1998, 1:201-217.
21. Wood B.D., Quintard M., Whitaker S. Calculation of effective diffusivities for biofilms and tissues. Biotechnol. Bioeng. 2002, 77:495-516.
22. Wood B.D., Whitaker S. Multi-species diffusion and reaction in biofilms and cellular media. Chem. Eng. Sci. 2000, 55:3397-3418.
23. Griffith L.G., Swartz M.A. Capturing complex 3D tissue physiology in vitro. Nat. Rev. Mol. Cell Biol. 2006, 7:211-224.
24. 2 transport within engineered hepatic devices. Biotechnol. Bioeng. 2003, 82(1):12-27.
25. Ye H., Das D.B., Triffitt J.T., Cui Z.F. Modelling nutrient transport in hollow fibre membrane bioreactors for growing three-dimensional bone tissue. J. Membr. Sci. 2006, 272:169-178.
26. Lysenko V., Vitiello J., Remaki B., Barbier D. Gas permeability of porous silicon nanostructures. Part 2. Phys. Rev. E 2004, 70(1). 017301.