Macroparasites, innate immunity and immunoregulation: Developing natural models

Trends in Parasitology

Volumn 26, Issue 11, 2010, Pages 540-549

  Friberg, Ida M ^a   Bradley, Janette E ^a   Jackson, Joseph A ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR; PROTEIN MD 2; PROTEIN SERINE THREONINE KINASE; PROTEINASE ACTIVATED RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; AUTOIMMUNITY; DISEASE TRANSMISSION; ECTOPARASITE; HELMINTHIASIS; HUMAN; IMMUNOREGULATION; INNATE IMMUNITY; MACROPARASITE; NEMATODIASIS; NONHUMAN; PARASITOSIS; REGULATORY T LYMPHOCYTE; REVIEW; SCHISTOSOMIASIS; T LYMPHOCYTE;

ANIMALS; ANIMALS, WILD; HOST-PARASITE INTERACTIONS; IMMUNITY, INNATE; IMMUNOLOGIC FACTORS; PARASITES; TOLL-LIKE RECEPTORS;

ANIMALIA;

EID: 77957930662     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2010.06.010     Document Type: Review

References (90)

1. Maizels R.M., Yazdanbakhsh M. Immune regulation by helminth parasites: cellular and molecular mechanisms. Nat. Rev. Immunol. 2003, 3:733-744.
2. + T cells. Parasit. Vectors 2009, 2:47.
3. Mangan N.E., et al. Helminth infection protects mice from anaphylaxis via IL-10-producing B Cells. J. Immunol. 2004, 173:6346-6356.
4. Jenkins S.J., Allen J.E. Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes. J. Biomed. Biotechnol. 2010, 2010:262609.
5. Perrigoue J.G., et al. On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites. Cell Microbiol. 2008, 10:1757-1764.
6. + regulatory T Cells control innate immune reactivity after injury. J. Immunol. 2005, 174:2957-2963.
7. Jackson J.A., et al. Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?. Immunology 2009, 126:18-27.
8. Zaccone P., et al. Parasitic worms and inflammatory diseases. Parasite Immunol. 2006, 28:515-523.
9. Akira S., et al. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
10. Matzinger P. The danger model: a renewed sense of self. Science 2002, 296:301-305.
11. Roach J.C., et al. The evolution of vertebrate Toll-like receptors. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:9577-9582.
12. van der Kleij D., et al. A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates Toll-like receptor 2 and affects immune polarization. J. Biol. Chem. 2002, 277:48122-48129.
13. Aksoy E., et al. Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J. Biol. Chem. 2005, 280:277-283.
14. MacDonald A.S., Maizels R.M. Alarming dendritic cells for Th2 induction. J. Exp. Med. 2008, 205:13-17.
15. Kane C.M., et al. Helminth antigens modulate TLR-initiated dendritic cell activation. J. Immunol. 2004, 173:7454-7461.
16. Semnani R.T., Nutman T.B. Toward an understanding of the interaction between filarial parasites and host antigen-presenting cells. Immunol. Rev. 2004, 201:127-138.
17. Helmby H., Grencis R.K. Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection. Eur. J. Immunol. 2003, 33:2974-2979.
18. Kerepesi L.A., et al. Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice. Microbes Infect. 2007, 9:28-34.
19. Jenkins S.J., et al. Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways. Int. Immunol. 2005, 17:1409-1418.
20. Layland L.E., et al. Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2. Eur. J. Immunol. 2007, 37:2174-2184.
21. Amrita D., et al. TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung. Eur. J. Immunol. 2008, 38:3436-3449.
22. Ince M.N., et al. Cutting edge: Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFβ after lipopolysaccharide stimulation. J. Immunol. 2006, 176:726-729.
23. Geijtenbeek T.B.H., Gringhuis S.I. Signalling through C-type lectin receptors: shaping immune responses. Nat. Rev. Immunol. 2009, 9:465-479.
24. van den Berg T.K., et al. LacdiNAc-glycans constitute a parasite pattern for Galectin-3-mediated immune recognition. J. Immunol. 2004, 173:1902-1907.
25. Zhao A., et al. Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis Infection. J. Immunol. 2005, 175:2563-2569.
26. Franchi L., et al. Function of Nod-like receptors in microbial recognition and host defense. Immunol. Rev. 2009, 227:106-128.
27. Yoneyama M., et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004, 5:730-737.
28. Babu S., et al. Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation. J. Immunol. 2005, 175:1170-1176.
29. Babu S., et al. Cutting edge: diminished T Cell TLR expression and function modulates the immune response in human filarial infection. J. Immunol. 2006, 176:3885-3889.
30. van der Kleij D., et al. Responses to Toll-like receptor ligands in children living in areas where schistosome infections are endemic. J. Infect. Dis. 2004, 189:1044-1051.
31. Jackson J.A., et al. Gastrointestinal nematode infection is associated with variation in innate immune responsiveness. Microbes Infect. 2006, 8:487-492.
32. Piao W., et al. Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-β-dependent pathways and increases expression of negative regulators of TLR signaling. J. Leukoc. Biol. 2009, 86:863-875.
33. Medvedev A.E., et al. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J. Immunol. 2002, 169:5209-5216.
34. Sato S., et al. A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int. Immunol. 2002, 14:783-791.
35. Trinchieri G., Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 2007, 7:179-190.
36. O'Neill L.A.J. When signaling pathways collide: positive and negative regulation of Toll-like receptor signal transduction. Immunity 2008, 29:12-20.
37. de Vos A.F., et al. In vivo lipopolysaccharide exposure of human blood leukocytes induces cross-tolerance to multiple TLR ligands. J. Immunol. 2009, 183:533-542.
38. Hovius J.W.R., et al. Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization. PLoS Pathog. 2008, 4:e31.
39. Pesce J.T., et al. Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response. J. Immunol. 2008, 180:464-474.
40. Turner J.D., et al. Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner. J. Immunol. 2006, 177:1240-1249.
41. Semnani R.T., et al. Inhibition of TLR3 and TLR4 function and expression in human dendritic cells by helminth parasites. Blood 2008, 112:1290-1298.
42. Venugopal P.G., et al. Activation and regulation of Toll-like receptors (TLRs) by helminth parasites. Immunol. Res. 2009, 43:252-263.
43. Brännström K., et al. The Schistosoma mansoni protein Sm16/SmSLP/SmSPO-1 assembles into a 9-subunit oligomer with potential to inhibit Toll-like receptor signaling. Infect. Immun. 2009, 77:1144-1154.
44. Goodridge H.S., et al. Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J. Immunol. 2005, 174:284-293.
45. Maizels R.M., et al. Immune evasion genes from filarial nematodes. Int. J. Parasitol. 2001, 31:889-898.
46. Smith P., et al. Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity. J. Exp. Med. 2005, 202:1319-1325.
47. Fitting C., et al. Compartmentalization of tolerance to endotoxin. J. Infect. Dis. 2004, 189:1295-1303.
48. Melendez A.J., et al. Inhibition of Fce{open}RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes. Nat. Med. 2007, 13:1375-1381.
49. Anthony R.M., et al. Protective immune mechanisms in helminth infection. Nat. Rev. Immunol. 2007, 7:975-987.
50. Ivashkiv L.B. Cross-regulation of signaling by ITAM-associated receptors. Nat. Immunol. 2009, 10:340-347.
51. Gerber J.S., Mosser D.M. Reversing lipopolysaccharide toxicity by ligating the macrophage Fcγ receptors. J. Immunol. 2001, 166:6861-6868.
52. Mueller T., et al. Th2 cytokines down-regulate TLR expression and function in human intestinal epithelial cells. J. Immunol. 2006, 176:5805-5814.
53. Månsson A., Cardell L.-O. Role of atopic status in Toll-like receptor (TLR)7- and TLR9-mediated activation of human eosinophils. J. Leukoc. Biol. 2009, 85:719-727.
54. Tanaka J., et al. Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2-polarizing conditions. Clin. Exp. Allergy 2009, 39:89-100.
55. Dong Kim K., et al. Adaptive immune cells temper initial innate responses. Nat. Med. 2007, 13:1248-1252.
56. Zhao J., et al. Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc. Natl Acad. Sci. U.S.A. 2008, 105:7528-7533.
57. Bradley J.E., Jackson J.A. Measuring immune system variation to help understand host-pathogen community dynamics. Parasitology 2008, 135:807-823.
58. Jackson J.A., et al. Immunomodulatory parasites and toll-like receptor-mediated tumour necrosis factor alpha responsiveness in wild mammals. BMC Biol. 2009, 7:13.
59. Anderson H.R., et al. 50 years of asthma: UK trends from 1955 to 2004. Thorax 2007, 62:85-90.
60. Linneberg A., et al. Secular trends of allergic asthma in Danish adults. The Copenhagen Allergy Study. Respir. Med. 2001, 95:258-264.
61. Orton S.-M., et al. Sex ratio of multiple sclerosis in Canada: a longitudinal study. Lancet Neurol. 2006, 5:932-936.
62. Patterson C.C., et al. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009, 373:2027-2033.
63. Zaccone P., et al. Interplay of parasite-driven immune responses and autoimmunity. Trends Parasitol. 2008, 24:35-42.
64. Halonen M., et al. Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort. J. Immunol. 2009, 182:3285-3293.
65. Hubeau C., et al. Adoptively transferred allergen-specific T cells cause maternal transmission of asthma risk. Am. J. Pathol. 2006, 168:1931-1939.
66. Auten R.L., et al. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. Am. J. Respir. Crit. Care Med. 2009, 180:1218-1226.
67. Prescott S.L., et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J. Immunol. 1998, 160:4730-4737.
68. Schaub B., et al. Impairment of T-regulatory cells in cord blood of atopic mothers. J. Allergy Clin. Immunol. 2008, 121:1491-1499.
69. Schaub B., et al. Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression. Respir. Res. 2006, 7:40.
70. Schaub B., et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J. Allergy Clin. Immunol. 2009, 123:774-782.
71. Turner J.D., et al. Intensity of intestinal infection with multiple worm species is related to regulatory cytokine output and immune hyporesponsiveness. J. Infect. Dis. 2008, 197:1204-1212.
72. Hewitson J.P., et al. Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. Mol. Biochem. Parasitol. 2009, 167:1-11.
73. Everts B., et al. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J. Exp. Med. 2009, 206:1673-1680.
74. Thomas P.G., et al. Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-Like Receptor 4-dependent mechanism. J. Immunol. 2003, 171:5837-5841.
75. Schramm G., et al. Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J. Immunol. 2007, 178:6023-6027.
76. Donnelly S., et al. Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J. 2008, 22:4022-4032.
77. Harnett W., Harnett M.M. Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics. Clin. Exp. Pharmacol. Physiol. 2006, 33:511-518.
78. Kane C.M., et al. Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88. Infect. Immun. 2008, 76:5754-5759.
79. Harcus Y., et al. C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Parasitol. Int. 2009, 58:461-470.
80. Thomas P.G., Harn D.A. Immune biasing by helminth glycans. Cell Microbiol. 2004, 6:13-22.
81. deSchoolmeester M.L., et al. The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity. Immunology 2009, 126:246-255.
82. Saunders S.P., et al. The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome Infection. Infect. Immun. 2009, 77:399-404.
83. Geijtenbeek T.B.H., et al. Pathogen recognition by DC-SIGN shapes adaptive immunity. Future Microbiol. 2009, 4:879-890.
84. Dalpke A.H., et al. Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology 2005, 116:203-212.
85. Wallet M.A., et al. MerTK is required for apoptotic cell-induced T cell tolerance. J. Exp. Med. 2008, 205:219-232.
86. Wilson M.S., et al. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J. Exp. Med. 2005, 202:1199-1212.
87. Summers R.W., et al. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology 2005, 128:825-832.
88. Huitu O., et al. Winter food supply limits growth of northern vole populations in the absence of predation. Ecology 2003, 84:2108-2118.
89. Pedersen A.B., Greives T.J. The interaction of parasites and resources cause crashes in a wild mouse population. J. Anim. Ecol. 2008, 77:370-377.
90. Smith A., et al. A role for vector-independent transmission in rodent trypanosome infection?. Int. J. Parasitol. 2006, 36:1359-1366.