Progression of renal tubulointerstitial fibrosis and expression of α-SMA, TGF-β 1and VDR in rat UUO models

Journal of Shanghai Jiaotong University (Medical Science)

Volumn 30, Issue 7, 2010, Pages

  Xie, Sheng Bin ^a   Wang, Wei Ming ^a   Chen, Nan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

smooth muscle actin; Renal tubulointerstitial fibrosis; Transforming growth factor 1; Unilateral ureteral obstruction; Vitamin D receptor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FIBRONECTIN; TRANSFORMING GROWTH FACTOR BETA1; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; NONHUMAN; PROTEIN EXPRESSION; RAT; RENAL TUBULOINTERSTITIAL FIBROSIS; URETER OBSTRUCTION; WESTERN BLOTTING;

EID: 77957927498     PISSN: 16748115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Nangaku M. Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure[J]. Intern Med, 2004, 43 (1): 9-17. (Pubitemid 38208370)
2. Klahr S, Morrissey J. Obstructive nephropathy and renal fibrosis [J]. Am J Physiol Renal Physiol, 2002, 283(5): F861-F875.
3. Sato M, Muragaki Y, Saika S, et al. Targeted disruption of TGF-beta1/ Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction [J]. J Clin Invest, 2003, 112(10); 1486-1494. (Pubitemid 38056275)
4. Tan X, Li Y, Lin Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy[J]. J Am Soc Nephrol, 2006, 17(12): 3382-3393. (Pubitemid 44865281)
5. Radford MC Jr, Donadio JV Jr, Bergstralh EJ, et al. Predicting renal outcome in IgA nephropathy[J]. J Am Soc Nephrol, 1997, 8 (2): 199-207.
6. Ohashi R, Shimizu A, Masuda Y, et al. Peritubular capillary regression during the progression of experimental obstructive nephropathy [J]. J Am Soc Nephrol, 2002, 13(7): 1795-1805. (Pubitemid 34700604)
7. Efrati S, Berman S, Chachashvili A, et al. Rosiglitazone treatment attenuates renal tissue inflammation generated by urinary tract obstruction[J]. Nephrology (Carlton), 2009, 14(2): 189-197.
8. Qi W, Chen X, Poronnik P, et al. The renal cortical fibroblast in renal tubulointerstitial fibrosis[J]. Int J Biochem Cell Biol, 2006, 38 (1): 1-5. (Pubitemid 41540710)
9. Picard N, Baum O, Vogetseder A, et al. Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat [J]. Histochem Cell Biol, 2008, 130(1): 141-155.
10. Kawai T, Masaki T, Doi S, et al. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through redaction of TGF-beta [J]. Lab Invest, 2009, 89(1): 47-58.
11. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGF beta activation[J]. J Cell Sci, 2003, 116 (Pt 2): 217-224.
12. Kumar R, Schaefer J, Grande JP, et al. Immunolocalization of cal-citriol receptor, 24-hydrosylase cytochrome P-450, and calbindin D28k in human kidney [J]. Am J Physiol, 1994, 266(3 Pt 2): F477-F485. (Pubitemid 2076688)
13. Doorenbos CR, van den Born J, Navis G, et al. Possible renoprotection by vitamin D in chronic renal disease; beyond mineral metabolism[J]. Nat Rev Nephrol, 2009, 5(12): 691-700.