The first human epitope map of the alphaviral E1 and E2 proteins reveals a new E2 epitope with significant virus neutralizing activity

PLoS Neglected Tropical Diseases

Volumn 4, Issue 7, 2010, Pages

  Hunt, Ann R ^a   Frederickson, Shana ^b,d   Maruyama, Toshiaki ^b,e   Roehrig, John T ^c   Blair, Carol D ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b Alexion Antibody Technologies Inc   (United States)

^c NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^d Life Technologies   (United States)

^e Calmune Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN E1; GLYCOPROTEIN E2; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PEPTIDE LIBRARY; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING SITE; BONE MARROW; CONTROLLED STUDY; CROSS REACTION; CRYOELECTRON MICROSCOPY; DONOR; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; NONHUMAN; PHAGE DISPLAY; SEQUENCE ANALYSIS; SINDBIS VIRUS; VENEZUELAN EQUINE ENCEPHALITIS; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; VIRUS NEUTRALIZATION; ANIMAL; DISEASE MODEL; DNA SEQUENCE; EPITOPE MAPPING; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; SERODIAGNOSIS;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; DISEASE MODELS, ANIMAL; ENCEPHALITIS VIRUS, VENEZUELAN EQUINE; ENCEPHALOMYELITIS, VENEZUELAN EQUINE; EPITOPE MAPPING; EPITOPES; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PEPTIDE LIBRARY; SEQUENCE ANALYSIS, DNA; VIRAL ENVELOPE PROTEINS;

EID: 77957923201     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000739     Document Type: Article

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