Cytotoxic evaluation of semisynthetic ester and amide derivatives of oleanolic acid

Natural Product Communications

Volumn 5, Issue 10, 2010, Pages 1567-1570

  Gupta, Shikha ^a   Kalani, Komal ^a   Saxena, Mohit ^a,c   Srivastava, Santosh K ^a   Agrawal, Satyam K ^b   Suri, Nitasha ^b   Saxena, Ajit K ^b  

^a CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c NATIONAL PHYSICAL LABORATORY   (India)

Author keywords

Cytotoxic activity; Human cancer cell lines; Lantana camara; Oleanolic acid derivatives; Structure activity relationship

Indexed keywords

DOXORUBICIN; FLUOROURACIL; LANTANA CAMARA EXTRACT; OLEANOLIC ACID; PACLITAXEL;

ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; OVARY CANCER; STRUCTURE ACTIVITY RELATION;

LANTANA CAMARA;

EID: 77957918897     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x1000501010     Document Type: Article

References (13)

1. Sparg SG, Light ME, Vanstadan J. (2004) Biological activities and distribution of plant saponins. Journal of Ethnopharmacology, 94, 219-243.
2. Liu J. (2005) Oleanolic acid and ursolic acid: Research perspectives. Journal of Ethnopharmacology, 100, 92-94.
3. Novonty L, Vachalkaova A, Biggs D. (2001) Ursolic acid: an anti-tumorigenic and chemopreventive activity. Neoplasma, 48, 241-243.
4. Haridas V, Arntzen C, Gutterman JU. (2001) Avicins, a family of triterpenoid saponins from Acacia victoriae Bentham, inhibit activation of nuclear factor- kB by inhibiting both its nuclear localization and ability to bind DNA. Journal of Proceedings of National Academic Sciences USA, 98, 11557-11562. (Pubitemid 32928767)
5. Jung H, Nam J, Croi J, Lee K, Park H. (2005) 19α-Hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa. Biological & Pharmaceutical Bulletin, 28, 101-104. (Pubitemid 40879791)
6. Ikeda T, Yokomizo K, Okawa M, Tsuchihashi R, Kinjo J, Nohara T, Uyeda M. (2005) Anti-Herpes virus type 1 activity of oleanane-type triterpenoids. Biological & Pharmaceutical Bulletin, 28, 1779-1781. (Pubitemid 41324153)
7. Saxena M, Faridi U, Mishra R, Gupta MM, Darokar MP, Srivastava SK, Singh D, Luqman S, Khanuja SPS. (2007) Cytotoxic agents from Terminalia arjuna. Planta Medica, 73, 1486-1490.
8. Tanachatchairatana T, Bremner JB, Chokchaisiri R, Suksamrarn A. (2008) Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids. Chemical and Pharmacetical Bulletin, 56, 194-198. (Pubitemid 351206646)
9. Assefa H, Nimrod A, Walker L, Sindelar R. (1999) Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid. Bioorganic and Medicinal Chemistry Letters, 9, 1889-1894. (Pubitemid 29336368)
10. Simone CBG, Luciana DV, Claiton LL, Alexandra D-K, Sophie DN, Djavad M, Jean G, Grace G, Pascal S. (2008) Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents. Journal of Enzyme Inhibition and Medicinal Chemistry, 23, 604-610.
11. Zhang Y, Li J-X, Zhao J, Wang S-Z, Pan Y, Tanaka K, Kadota S. (2005) Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation, Bioorganic and Medicinal Chemistry Letters, 15, 1629-1632 (Pubitemid 40312543)
12. Sondhi SM, Rani R, Gupta PP, Agrawal SK, Saxena AK. (2009) Synthesis, anticancer and anti-inflammatory activity evaluation of some novel methanesulfonamide and amidine derivatives of 3, 4-diaryl-2-imino-4-thiazolines. Molecular Diversity, 13, 357-366.
13. Skehan P, Storeng R, Scudiero D, Monks A, McMohan J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR. (1990) New colorimetric cytotoxic assay for anticancer-drug screening. Journal of National Canadian Institutions, 82, 1107-1112. (Pubitemid 20213250)