Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore: The domestic cat (felis catus)

British Journal of Nutrition

Volumn 104, Issue 7, 2010, Pages 972-979

  Verbrugghe, Adronie ^a   Janssens, Geert P J ^a   Meininger, Eva ^a   Daminet, Sylvie ^a   Piron, Koen ^a   Vanhaecke, Lynn ^a   Wuyts, Birgitte ^b   Buyse, Johan ^c   Hesta, Myriam ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c LABORATORY OF GENE TECHNOLOGY   (Belgium)

Author keywords

Acylcarnitine; Carnivore; Dietary fibre; Gluconeogenesis; Propionate

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYLCARNITINE; ACYLCARNITINE; CARNITINE DERIVATIVE; CELLULOSE; FRUCTOSE OLIGOSACCHARIDE; INULIN; METHYLMALONYLCARNITINE; NITROGEN; PROPIONYLCARNITINE; UNCLASSIFIED DRUG; AMINO ACID; CARNITINE; DRUG DERIVATIVE; OLIGOSACCHARIDE; PREBIOTIC AGENT; PROPIONIC ACID; PROPIONIC ACID DERIVATIVE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CAT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY FIBER; DIGESTION; EXCRETION; FECES ANALYSIS; FEMALE; FERMENTATION; FOOD INTAKE; INTESTINAL FERMENTATION; MALE; NITROGEN METABOLISM; NONHUMAN; POLYMERIZATION; POSTPRANDIAL STATE; URINALYSIS; ANIMAL; BACTERIUM; CROSSOVER PROCEDURE; GLUCONEOGENESIS; INTESTINE; METABOLISM; MICROBIOLOGY; PROTEIN INTAKE;

FELIS CATUS;

AMINO ACIDS; ANIMALS; AREA UNDER CURVE; BACTERIA; CARNITINE; CATS; CROSS-OVER STUDIES; DIETARY PROTEINS; DIETARY SUPPLEMENTS; FEMALE; FERMENTATION; GLUCONEOGENESIS; INTESTINES; INULIN; MALE; NITROGEN; OLIGOSACCHARIDES; POSTPRANDIAL PERIOD; PREBIOTICS; PROPIONIC ACIDS;

EID: 77957913672     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510001558     Document Type: Article

References (44)

1. Johnston K, Lamport A & Batt RM (1993) An unexpected bacterial-flora in the proximal small-intestine of normal cats. Vet Rec 132, 362-363.
2. Papasouliotis K, Sparkes AH, Werrett G, et al. (1998) Assessment of the bacterial flora of the proximal part of the small intestine in healthy cats, and the effect of sample collection method. Am J Vet Res 59, 48-51.
3. Sparkes AH, Papasouliotis K, Sunvold G, et al. (1998) Bacterial flora in the duodenum of healthy cats, and effect of dietary supplementation with fructo-oligosaccharides. Am J Vet Res 59, 431-435.
4. Cummings JH, Pomare EW, Branch WJ, et al. (1987) Short chain fatty-acids in human large-intestine, portal, hepatic and venous-blood. Gut 28, 1221-1227.
5. Roberfroid MB & Delzenne NM (1998) Dietary fructans. Annu Rev Nutr 18, 117-143.
6. von Engelhardt W (2004) Absorption of short-chain fatty acids from the large intestine. In Physiological and Clinical Aspects of Short-chain Fatty Acids, pp. 149-170 [JH Cummings, JL Rombeau and T Sakata, editors]. Cambridge, UK: Cambridge University Press.
7. Rémésy C, Demigné C & Morand C (2004) Metabolism of short-chain fatty acids in the liver. In Physiological and Clinical Aspects of Short-chain Fatty Acids, pp. 171-190 [JH Cummings, JL Rombeau and T Sakata, editors]. Cambridge, UK: Cambridge University Press.
8. Anderson JW & Bridges SR (1984) Short-chain fatty-acid fermentation products of plant fiber affect glucose-metabolism of isolated rat hepatocytes. Proc Soc Exp Biol Med 177, 372-376.
9. Blair JB, Cook DE & Lardy HA (1973) Interaction of propionate and lactate in perfused rat-liver - effects of glucagon and oleate. J Biol Chem 248, 3608-3614.
10. Petitet S, Morand C, Besson C, et al. (1998) Effects of propionate on rat hepatocyte metabolism. J Nutr Biochem 9, 652-658.
11. Washizu T, Tanaka A, Sako T, et al. (1999) Comparison of the activities of enzymes related to glycolysis and gluconeogenesis in the liver of dogs and cats. Res Vet Sci 67, 205-206.
12. Tanaka A, Inoue A, Takeguchi A, et al. (2005) Comparison of expression of glucokinase gene and activities of enzymes related to glucose metabolism in livers between dog and cat. Vet Res Commun 29, 477-485.
13. Ballard FJ (1965) Glucose utilization in mammalian liver. Comp Biochem Physiol 14, 437-443.
14. Arai T, Washizu T, Sako T, et al. (1992) D-Glucose transport activities in erythrocytes and hepatocytes of dogs, cats and cattle. Comp Biochem Physiol A Physiol 102, 285-287.
15. Verbrugghe A, Hesta M, Gommeren K, et al. (2009) Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats. Br J Nutr 102, 694-702.
16. Bremer J (1983) Carnitine - metabolism and functions. Physiol Rev 63, 1420-1480.
17. Brass EP & Hoppel CL (1980) Relationship between acidsoluble carnitine and coenzyme A pools in vivo. Biochem J 190, 495-504.
18. Vreken P, van Lint AEM, Bootsma AH, et al. (1999) Rapid diagnosis of organic acidemias and fatty-acid oxidation defects by quantitative electrospray tandem-MS acyl-carnitine analysis in plasma. In Current Views of Fatty Acid Oxidation and Ketogenesis - from Organelles to Point Mutations, pp. 327-337 [PA Quant and S Eaton, editors]. New York: Kluwer.
19. National Research Council (NRC) (2006) Energy. In Nutrient Requirements of Dogs and Cats, pp. 28-48. Washington, DC: The National Academies Press.
20. Scarlett JM, Donoghue S, Saidla J, et al. (1994) Overweight cats - prevalence and risk-factors. Int J Obs 18, S22-S28.
21. Martin GJW & Rand JS (1999) Evaluation of a polyurethane jugular catheter in cats placed using a modified Seldinger technique. Aust Vet J 77, 250-254.
22. AOAC (1995) AOAC Method 920.40. In Official Methods of Analysis, 16th ed., [P Cunniff, editor]. Washington, DC: Association of official analytical chemists.
23. AOAC (1995) AOAC Method 962.09. Determination of crude fibre in feeds. In Official Methods of Analysis, 16th ed., [P Cunniff, editor]. Washington, DC: Association of official analytical chemists.
24. Van Soest PJ, Robertson JB & Lewis BA (1991) Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J Dairy Sci 74, 3583-3597.
25. AOAC (1995) AOAC Method 985.29. Total dietary fibre in foods: Enzymatic-gravimetric method. In Official Methods of Analysis, 16th ed., [P Cunniff, editor]. Washington, DC: Association of official analytical chemists.
26. Prosky L & Hoebregs H (1999) Methods to determine food inulin and oligofructose. J Nutr 129, 1418S-1423S.
27. Mason V (1969) Some observations on the distribution and origin of nitrogen in sheep faeces. J Agric Sci 73, 99-111.
28. Hesta M, Roosen W, Janssens GPJ, et al. (2003) Prebiotics affect nutrientdigestibility but not faecal ammonia in dogs fed increased dietary protein levels. Br J Nutr 90, 1007-10014.
29. Van Nevel CJV & Demeyer DI (1977) Effect of monensin on rumen metabolism in-vitro. Appl Environ Microbiol 34, 251-257.
30. Hesta M, Hoornaert E, Sales J, et al. (2005) The effect of oligofructose and inulin on urea metabolism and faecal odour components in cats. J Anim Physiol Anim Nutr 89, 208-214.
31. Rizzo C, Boenzi S, Wanders RJA, et al. (2003) Characteristic acylcarnitine profiles in inherited defects of peroxisome biogenesis: A novel tool for screening diagnosis using tandem mass spectrometry. Ped Res 53, 1013-1018.
32. Rowland M & Tozer TN (1995) Additional concepts and derivations. Appendix 1.A. Assessment of AUC. In Clinical Pharmacokinetics: Concepts and Applications, pp. 469-472 [D Balado, F Klass, L Stead, L Forsyth and RD Magee, editors]. Philadelphia, PA: Lippincort Williams & Wilkins.
33. Sunvold GD, Hussein HS, Fahey GC, et al. (1995) In vitro fermentation of cellulose, beet pulp, citru pulp, and citrus pectin using fecal inoculum from cats, dogs, horses, humans and pigs and ruminal fluid from cattle. J Anim Sci 73, 3639-3648.
34. Sunvold GD, Fahey GC, Merchen NR, et al. (1995) In vitro fermentation of selected fibrous substrates by dog and cat fecal inoculum: Influence of diet composition on substrate organic matter disappearance and short-chain fatty acid production. J Anim Sci 73, 1110-1122.
35. Hesta M, Janssens GPJ, Debraekeleer J, et al. (2001) The effect of oligofructose and inulin on faecal characteristics and nutrient digestibility in healthy cats. J Anim Physiol Anim Nutr 85, 135-141.
36. Hesta M, Debraekeleer J, Janssens GPJ, et al. (2006) Effects of prebiotics in dog and cat nutrition: A review. In Trends in Dietary Carbohydrates Research, pp. 179-219 [MV Landlow, editor]. New York: Nova Science Publishers, Inc.
37. Roberfroid M (1993) Dietary fiber, inulin and oligofructose: A review comparing their physiologic effects. Crit Rev Food Sci Nutr 33, 103-148.
38. Hesta M, Hoornaert E, Sales J, et al. (2005) The effect of oligofructose on urea metabolism and faecal odour components in cats. J Anim Physiol Anim Nutr 89, 208-214.
39. Terada A, Hara H, Kato S, et al. (1993) Effect of lactosucrose (4G-b-D-galactosylsucrose) on fecal flora and fecal putrefactive products in cats. J Vet Med Sci 55, 291-295.
40. Roe CR, Millington DS & Maltby DA (1986) Identification of 3-methylglutarylcarnitine - a new diagnostic metabolite of 3-hydroxy-3- methylglutaryl-coenzyme-A lyase deficiency. J Clin Invest 77, 1391-1394.
41. Howard M, Kerley M, Sunvold G, et al. (2000) Sources of dietary fiber fed to dogs affects nitrogen and energy balance and intestinal microflora populations. Nutr Res 20, 1473-1484.
42. Younes H, Garleb K, Behr S, et al. (1995) Fermentable fibers or oligosaccharides reduce urinary nitrogen excretion by increasing urea disposal in the rat caecum. J Nutr 125, 1010-1016.
43. Younes H, Rémésy C, Behr S, et al. (1997) Fermentable carbohydrate exerts a urea-lowering effect in normal and nephrectomised rats. Am J Physiol Gastroint Liver Physiol 272, G515-G521.
44. Grauer GF (2003) Clinical manifestation of urinary disorders. In Small Animal Internal Medicine, pp. 568-583 [RW Nelson and CG Couto, editors]. St Louis, MO: Mosby, Inc.