Hormonal Treatment of Male Idiopathic/Isolated Hypogonadotropic Hypogonadism

Journal of Reproduction and Contraception

Volumn 21, Issue 3, 2010, Pages 179-189

  MA, Ying ^a   ZHANG, Xue hong ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Hormones; Hypogonadism; Infertility; Spermatogenesis; Therapeutics

Indexed keywords

ADENOHYPOPHYSIS HORMONE; ANASTROZOLE; ANTIESTROGEN; CHORIONIC GONADOTROPIN; CLOMIFENE; CLOMIFENE CITRATE; FOLLITROPIN; GONADORELIN; HUMAN MENOPAUSAL GONADOTROPIN; RECOMBINANT FOLLITROPIN; TAMOXIFEN; TESTOSTERONE;

ANDROGEN THERAPY; DRUG DOSE INCREASE; HORMONE DETERMINATION; HORMONE SUBSTITUTION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM; LABORATORY TEST; MALE INFERTILITY; MENTAL HEALTH; MORBIDITY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SEXUAL FUNCTION; TREATMENT DURATION;

EID: 77957904631     PISSN: 10017844     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1001-7844(10)60026-0     Document Type: Review

References (44)

1. Pitteloud N, Durrani S, Raivio T, et al. Complex genetics in idiopathic hypogonadotropic hypogonadism. Front Horm Res 2010, 39:142-153.
2. Bhagavath B, Layman LC The genetics of hypogonado-tropic hypogonadism. Semin Reprod Med 2007, 25(4):272-286.
3. Balsamo A, Antelli A, Baldazzi L, et al. A new DAX1 gene mutation associated with congenital ad-renal hypoplasia and hypogonadotropic hypogonadism. Am J Med Genet A 2005, 135(3):292-296.
4. Bouligand J, Ghervan C, Guiochon-Mantel A, et al. Hypogonadism and GNRH1 mutations in mice and humans. Front Horm Res 2010, 39:111-120.
5. Kobayashi T, Okuno H, Nishiyama H, et al. Adult-onset idiopathic hypogonadotropic hypogonadism presented with erectile and ejaculatory disorder. Int J Urol 2002, 9(10):605-606.
6. Volpi R, Ugolotti MC, Carbucicchio A, et al. Idiopathic hypogonadotropic hypogonadism in selective human gonadotropin deficiency in adult man: a case report. Acta Biomed 2008, 79(3):251-254.
7. Suzuki F, Shimizu C, Umetsu M, et al. Adult-onset idiopathic hypogonadotropic hypogonadism due to isolated pituitary gonadotropin deficiency. Intern Med 2004, 43(7):571-574.
8. Terao H, Ogawa T, Yanagisawa, et al. A case of adult-onset idiopathic hypogonadotropic hypogonadism presenting with infertility. Hinyokika Kiyo 2009, 55(7):437-439.
9. Diagnostics of Reproduction Disease 2006, 174. Shanghai Scientific & Technical Publishers, Shanghai. M.Z. Wu, Q.D. Lin (Eds.).
10. Nan Ke Xue 2004, 1389-1399. People's Medical Publishing House, Beijing. Y.L. Guo, L.Q. Hu (Eds.).
11. Balasubramanian R, Dwyer A, Seminara SB, et al. Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons. Neuroendocrinology 2010, 92(2):81-99.
12. Liu L, Banks SM, Barnes KM, et al. Two-year comparison of testicular responses to pulsatile gonadotropinreleasing hormone and exogenous gonadotropins from the inception of therapy in men with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1988, 67(6):1140-1145.
13. Gruenewald DA, Matsumoto AM Testosterone supplementation therapy for older men: potential benefits and risks. J Am Geriatr Soc 2003, 51(1):101-115.
14. Seftel A Testosterone replacement therapy for male hypogonadism: part III. Pharmacologic and clinical profiles, monitoring, safety issues, and potential future agents. Int J Impot Res 2007, 19(1):2-24.
15. Byrne MM, Nieschlag E Testosterone replacement therapy in male hypogonadism. J Endocrinol Invest 2003, 26(5):481-489.
16. Minnemann T, Schubert M, Freude S, et al. Comparison of a new long-acting testosterone undecanoate formulation vs testosterone enanthate for intramuscular androgen therapy in male hypogonadism. J Endocrinol Invest 2008, 31(8):718-723.
17. Jockenhövel F, Minnemann T, Schubert M, et al. Comparison of long-acting testosterone undecanoate formulation versus testosterone enanthate on sexual function and mood in hypogonadal men. Eur J Endocrinol 2009, 160(5):815-819.
18. Bhasin S, Bremner WJ Emerging issues in androgen replacement therapy. J Clin Endocrinol Metab 1997, 82(1):3-8.
19. Büchter D, Behre HM, Kliesch S, et al. Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol 1998, 139(3):298-303.
20. Kirk JM, Savage MO, Grant DB, et al. Gonadal function and response to human chorionic and menopausal gonadotrophin therapy in male patients with idiopathic hypogonadotrophic hypogonadism. Clin Endocrinol (Oxf) 1994, 41(1):57-63.
21. Di FS, Cui YG, Jia Y The application of gonadotropin in treatment of male central hypogonadism. Zhonghua Nei Ke Za Zhi (in Chinese) 2005, 44(11):836-839.
22. Yazici M, Sahin M, Bolu E, et al. Prediction of testosterone response to human chorionic gonadotrophin in idiopathic hypogonadotropic hypogonadism patients. J Natl Med Assoc 2009, 101(1):71-76.
23. Ioannidou-Kadis S, Wright PJ, Neely RD, et al. Complete reversal of adult-onset isolated hypogonadotropic hypogonadism with clomiphene citrate. Fertil Steril 2006, 86(5):1513.e5-1513.e9.
24. Barrio R, de Luis D, Alonso M, et al. Induction of puberty with human chorionic gonadotropin and folliclestimulating hormone in adolescent males with hypogonadotropic hypogonadism. Fertil Steril 1999, 71(2):244-248.
25. Raivio T, Wikström AM, Dunkel L Treatment of gonadotropin-deficient boys with recombinant human FSH: long-term observation and outcome. Eur J Endocrinol 2007, 156(1):105-111.
26. Bouloux P, Warne DW, Loumaye E Efficacy and safety of recombinant human follicle-stimulating hormone in men with isolated hypogonadotropic hypogonadism. Fertil Steril 2002, 77(2):270-273.
27. Bouloux PM, Nieschlaq E, Burqer HG, et al. Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone. J Androl 2003, 24(4):604-611.
28. Sinisi AA, Esposito D, Maione L, et al. Seminal anti-Müllerian hormone level is a marker of spermatogenic response during long-term gonadotropins therapy in male hypogonadotropic hypogonadism. Hum Reprod 2008, 23(5):1029-1034.
29. Hoffman AR, Crowley WF Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormone. N Engl J Med 1982, 307(20):1237-1241.
30. Delemarre-Van de Waal HA Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism - diagnostic and therapeutic aspects. Eur J Endocrinol 2004, 151(Suppl 3):U89-U94.
31. Pitteloud N, Hayes FJ, Dwyer A, et al. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2002, 87(9):4128-4136.
32. Delemarre-Van de Waal HA, Odink RJ Pulsatile GnRH treatment in boys and girls with idiopathic hypogonadotrophic hypogonadism. Hum Reprod 1993, 8(Suppl 2):180-183.
33. Nachtiqall LB, Boepple PA, Pralong FP, et al. Adult-onset Idiopathic hypogonadotropic hypogonadism - a treatable form of male infertility. N Engl J Med 1997, 336(6):410-415.
34. Miyaqawa Y, Tsujimura A, Matsumiya K, et al. Outcome of gonadotropins therapy for male hypogonadotropic hypogonadism at university affliated male infertility centers: a 30-year retrospective study. J Urol 2005, 173(6):2072-2075.
35. Depenbush M, von Eckardstein S, Simoni M, et al. Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone. Eur J Endocrinol 2002, 147(5):617-624.
36. Lev SB, Leonard JM Male hypogonadotropic hypogonadism: factors influencing response to human chorionic gonadotropin and human menopausal gonadotropin, including prior exogenous androgens. J Clin Endocrinol Metab 1985, 61(4):746-752.
37. Burris AS, Rodbard HW, Winters SJ, et al. Gonadotropin therapy in men with isolated hypogonadotropic hypogonadism: the response to human chorionic gonadotropin is predicted by initial testicular size. J Clin Endocrinol Metab 1988, 66(6):1144-1151.
38. Vicari E, Mongioi A, Calogero AE, et al. Therapy with human chorionic gonadotrophin alone induces spermatogenesis in men with isolated hypogonadotrophic hypogonadism - long-term follow-up. Int J Androl 1992, 15(4):320-329.
39. Whitten SJ, Nanqia AK, Kolettis PN Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate. Fertil Steril 2006, 86(6):1664-1668.
40. Loves S, Ruinemans-Koerts J, de Boer H Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism. Eur J Endocrinol 2008, 158(5):741-747.
41. Holbrook JM, Cohen PG Aromatase inhibition for the treatment of idiopathic hypogonadotropic hypogonadism in men with premature ejaculation. South Med J 2003, 96(6):544-547.
42. Raivio T, Falardeau J, Dwver A, et al. Reversal of Idiopathic hypogonadotropic hypogonadism. N Engl J Med 2007, 357(9):863-873.
43. Dwyer AA, Hayes FJ, Plummer L, et al. The long-term clinical follow-up and natural history of men with adult-onset idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2010, Epub online. 10.1210/jc.2010-0245.
44. Meseguer M, Garrido N, Remohí J, et al. Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) in hypogonadotropic hypogonadism with persistent azoospermia after hormonal therapy. J Assist Genet 2004, 21(3):91-94.