Life-span phenotypes of elav and rbp9 in Drosophila suggest functional Cooperation of the two elav-family protein genes

Archives of Insect Biochemistry and Physiology

Volumn 74, Issue 4, 2010, Pages 261-265

  Toba, Gakuta ^a,b   Yamamoto, Daisuke ^b   White, Kalpana ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Genetics; Longevity; Mutants; Neurons; RNA binding proteins

Indexed keywords

DROSOPHILA PROTEIN; ELAV PROTEIN, DROSOPHILA; HU ANTIGEN; NERVE PROTEIN; RBP9 PROTEIN, DROSOPHILA; RNA BINDING PROTEIN;

ANIMAL; ARTICLE; DROSOPHILA; FEMALE; GENETICS; LONGEVITY; MALE; METABOLISM; MUTATION; NERVE CELL; PHENOTYPE; PHYSIOLOGY;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; LONGEVITY; MALE; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PHENOTYPE; RNA-BINDING PROTEINS;

EID: 77957902491     PISSN: 07394462     EISSN: 15206327     Source Type: Journal    
DOI: 10.1002/arch.20377     Document Type: Article

References (19)

1. Campos AR, Grossman D, White K. 1985. Mutant alleles at the locus elav in Drosophila melanogaster lead to nervous system defects. A developmental-genetic analysis. J Neurogenet 2:197-218.
2. Campos AR, Rosen DR, Robinow SN, White K. 1987. Molecular analysis of the locus elav in Drosophila melanogaster: a gene whose embryonic expression is neural specific. EMBO J 6:425-431.
3. Fialcowitz-White EJ, Brewer BY, Ballin JD, Willis CD, Toth EA, Wilson GM. 2007. Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNAdestabilizing sequences. J Biol Chem 282:20948-20959.
4. Gao FB, Keene JD. 1996. Hel-N1/Hel-N2 proteins are bound to poly(A)1 mRNA in granular RNP structures and are implicated in neuronal differentiation. J Cell Sci 109:579-589.
5. Hinman MN, Lou H. 2008. Diverse molecular functions of Hu proteins. Cell Mol Life Sci 65:3168-3181.
6. Homyk Jr T, Isono K, Pak WL. 1985. Developmental and physiological analysis of a conditional mutation affecting photoreceptor and optic lobe development in Drosophila melanogaster. J Neurogenet 2:309-324.
7. Jiménez F, Campos-Ortega JA. 1987. Genes in subdivision 1B of the Drosophila melanogaster X-chromosome and their influence on neural development. J Neurogenet 4:179-200.
8. Kasashima K, Sakashita E, Saito K, Sakamoto H. 2002. Complex formation of the neuronspecific ELAV-like Hu RNA-binding proteins. Nucleic Acids Res 15:4519-4526.
9. Kim J, Kim YJ, Kim-Ha J. 2010. Blood-brain barrier defects associated with Rbp9 mutation. Mol Cells 29:93-98.
10. Kim YJ, Baker BS. 1993. The Drosophila gene rbp9 encodes a protein that is a member of a conserved group of putative RNA binding proteins that are nervous system-specific in both flies and humans. J Neurosci 13:1045-1056.
11. Kim-Ha J, Kim J, Kim YJ. 1999. Requirement of RBP9, a Drosophila Hu homolog, for regulation of cystocyte differentiation and oocyte determination during oogenesis. Mol Cell Biol 19:2505-2514.
12. Lee SH, Kim Y, Kim-Ha J. 2000. Requirement of Rbp9 in the maintenance of Drosophila germline sexual identity. FEBS Lett 465:165-168.
13. Pascale A, Gusev PA, Amadio M, Dottorini T, Govoni S, Alkon DL, Quattrone A. 2004. Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Proc Natl Acad Sci USA 101:1217-1222.
14. Pascale A, Amadio M, Quattrone A. 2008. Defining a neuron: neuronal ELAV proteins. Cell Mol Life Sci 65:128-140.
15. Quattrone A, Pascale A, Nogues X, Zhao W, Gusev P, Pacini A, Alkon DL. 2001. Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins. Proc Natl Acad Sci USA 98:11668-11673.
16. Robinow S, White K. 1988. The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages. Dev Biol 126:294-303.
17. Robinow S, White K. 1991. Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J Neurobiol 22:443-461.
18. Soller M, White K. 2005. ELAV multimerizes on conserved AU4-6 motifs important for ewg splicing regulation. Mol Cell Biol 25:7580-7591.
19. Toba G, White K. 2008. The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization. Nucleic Acids Res 36:1390-1399.