Aborted cardiac arrest in a patient carrying KCNE1 D85N variant during the postpartum period

Internal Medicine

Volumn 49, Issue 17, 2010, Pages 1875-1878

  Nakajima, Tadashi ^a   Kaneko, Yoshiaki ^a   Manita, Mamoru ^b   Iso, Tatsuya ^a   Kurabayashi, Masahiko ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b National Hospital Organization   (Japan)

Author keywords

KCNE1; Long QT syndrome; Postpartum period; Ventricular tachyarrhythmias

Indexed keywords

ISOPRENALINE; POTASSIUM CHANNEL KCNE1;

ADULT; ARTICLE; AUTOPSY; CARDIOMEGALY; CASE REPORT; CONSCIOUSNESS DISORDER; CONTROLLED STUDY; DEATH; DEFIBRILLATION; DELIVERY; ECG ABNORMALITY; ECHOCARDIOGRAPHY; FAMILY HISTORY; FEMALE; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC VARIABILITY; HEART ARREST; HEART MUSCLE NECROSIS; HEART VENTRICLE FIBRILLATION; HETEROZYGOTE; HUMAN; HUMAN TISSUE; LONG QT SYNDROME; LUNG CONGESTION; MULTIPLE ORGAN FAILURE; MUTATION RATE; MUTATIONAL ANALYSIS; PUERPERIUM; QT INTERVAL; QT PROLONGATION; RESUSCITATION; SINGLE NUCLEOTIDE POLYMORPHISM; SINUS BRADYCARDIA; SINUS TACHYCARDIA; THORAX RADIOGRAPHY;

ALLELES; BRADYCARDIA; FATAL OUTCOME; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEART ARREST; HUMANS; LACTATION; LONG QT SYNDROME; MULTIPLE ORGAN FAILURE; POINT MUTATION; POTASSIUM CHANNELS, VOLTAGE-GATED; PUERPERAL DISORDERS; SIBLINGS; TACHYCARDIA, VENTRICULAR; YOUNG ADULT;

EID: 77957901423     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.49.3859     Document Type: Article

References (7)

1. Rashba EJ, Zareba W, Moss AJ, et al. Influence of pregnancy on the risk for cardiac events in patients with hereditary long QT syndrome. LQTS Investigators. Circulation 97: 451-456, 1998.
2. Khositseth A, Tester DJ, Will ML, Bell CM, Ackerman MJ. Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome. Heart Rhythm 1: 60-64, 2004.
3. Seth R, Moss AJ, McNitt S, et al. Long QT syndrome and pregnancy. J Am Coll Cardiol 49: 1092-1098, 2007.
4. Nishio Y, Makiyama T, Itoh H, et al. D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome. J Am Coll Cardiol 54: 812-819, 2009.
5. Ackerman MJ, Tester DJ, Jones GS, Will ML, Burrow CR, Curran ME. Ethnic differences in cardiac potassium channel variants: implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome. Mayo Clin Proc 78: 1479-1487, 2003.
6. Gouas L, Nicaud V, Berthet M, et al. Association of KCNQ1, KCNE1, KCNH2 and SCN5A polymorphisms with QTc interval length in a healthy population. Eur J Hum Genet 13: 1213-1222, 2005.
7. Makielski JC, Ye B, Valdivia CR, et al. A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels. Circ Res 93: 821-828, 2003.