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Volumn 5, Issue 1, 2010, Pages

RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer

Author keywords

[No Author keywords available]

Indexed keywords

ATOH1 PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL SURFACE RECEPTOR; CYCLINE; EYE PROTEIN; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; NOTCH RECEPTOR; PAIRED BOX TRANSCRIPTION FACTOR; PATCHED RECEPTORS; RBPJ PROTEIN, MOUSE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR PAX6;

EID: 77957900793     PISSN: None     EISSN: 17498104     Source Type: Journal    
DOI: 10.1186/1749-8104-5-27     Document Type: Article
Times cited : (6)

References (51)
  • 1
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: cell fate control and signal integration in development
    • 10.1126/science.284.5415.770, 10221902
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776. 10.1126/science.284.5415.770, 10221902.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 2
    • 0033697009 scopus 로고    scopus 로고
    • Radial glial identity is promoted by Notch1 signaling in the murine forebrain
    • 10.1016/S0896-6273(00)81172-1, 10839358
    • Gaiano N, Nye JS, Fishell G. Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron 2000, 26:395-404. 10.1016/S0896-6273(00)81172-1, 10839358.
    • (2000) Neuron , vol.26 , pp. 395-404
    • Gaiano, N.1    Nye, J.S.2    Fishell, G.3
  • 3
    • 31444447881 scopus 로고    scopus 로고
    • Notch signalling in vertebrate neural development
    • 10.1038/nrn1847, 16429119
    • Louvi A, Artavanis-Tsakonas S. Notch signalling in vertebrate neural development. Nat Rev Neurosci 2006, 7:93-102. 10.1038/nrn1847, 16429119.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 93-102
    • Louvi, A.1    Artavanis-Tsakonas, S.2
  • 4
    • 17244380473 scopus 로고    scopus 로고
    • Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex
    • 10.1242/dev.01693, 15750183
    • Mizutani K, Saito T. Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex. Development 2005, 132:1295-1304. 10.1242/dev.01693, 15750183.
    • (2005) Development , vol.132 , pp. 1295-1304
    • Mizutani, K.1    Saito, T.2
  • 5
    • 34447517526 scopus 로고    scopus 로고
    • Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems
    • 10.1242/dev.005520, 2653864, 17537790
    • Taylor MK, Yeager K, Morrison SJ. Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development 2007, 134:2435-2447. 10.1242/dev.005520, 2653864, 17537790.
    • (2007) Development , vol.134 , pp. 2435-2447
    • Taylor, M.K.1    Yeager, K.2    Morrison, S.J.3
  • 6
    • 10344264425 scopus 로고    scopus 로고
    • Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
    • 10.1242/dev.01436, 15496443
    • Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R. Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development 2004, 131:5539-5550. 10.1242/dev.01436, 15496443.
    • (2004) Development , vol.131 , pp. 5539-5550
    • Hatakeyama, J.1    Bessho, Y.2    Katoh, K.3    Ookawara, S.4    Fujioka, M.5    Guillemot, F.6    Kageyama, R.7
  • 7
    • 0035939462 scopus 로고    scopus 로고
    • Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development
    • 10.1002/cne.1059, 11438922
    • Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI. Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. J Comp Neurol 2001, 436:167-181. 10.1002/cne.1059, 11438922.
    • (2001) J Comp Neurol , vol.436 , pp. 167-181
    • Irvin, D.K.1    Zurcher, S.D.2    Nguyen, T.3    Weinmaster, G.4    Kornblum, H.I.5
  • 9
    • 0036471609 scopus 로고    scopus 로고
    • Molecular mechanisms underlying cell fate specification in the developing telencephalon
    • 10.1016/S0959-4388(02)00286-6, 11861161
    • Schuurmans C, Guillemot F. Molecular mechanisms underlying cell fate specification in the developing telencephalon. Curr Opin Neurobiol 2002, 12:26-34. 10.1016/S0959-4388(02)00286-6, 11861161.
    • (2002) Curr Opin Neurobiol , vol.12 , pp. 26-34
    • Schuurmans, C.1    Guillemot, F.2
  • 10
    • 0035974898 scopus 로고    scopus 로고
    • Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation
    • 10.1016/S0896-6273(01)00395-6, 11545715
    • Solecki DJ, Liu XL, Tomoda T, Fang Y, Hatten ME. Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation. Neuron 2001, 31:557-568. 10.1016/S0896-6273(01)00395-6, 11545715.
    • (2001) Neuron , vol.31 , pp. 557-568
    • Solecki, D.J.1    Liu, X.L.2    Tomoda, T.3    Fang, Y.4    Hatten, M.E.5
  • 11
    • 56749163716 scopus 로고    scopus 로고
    • Notch: from neural development to neurological disorders
    • 10.1111/j.1471-4159.2008.05715.x, 19094054
    • Lathia JD, Mattson MP, Cheng A. Notch: from neural development to neurological disorders. J Neurochem 2008, 107:1471-1481. 10.1111/j.1471-4159.2008.05715.x, 19094054.
    • (2008) J Neurochem , vol.107 , pp. 1471-1481
    • Lathia, J.D.1    Mattson, M.P.2    Cheng, A.3
  • 12
    • 0012221031 scopus 로고    scopus 로고
    • The notch pathway: modulation of cell fate decisions in hematopoiesis
    • 10.1007/BF02982106, 12095143
    • Ohishi K, Varnum-Finney B, Bernstein ID. The notch pathway: modulation of cell fate decisions in hematopoiesis. Int J Hematol 2002, 75:449-459. 10.1007/BF02982106, 12095143.
    • (2002) Int J Hematol , vol.75 , pp. 449-459
    • Ohishi, K.1    Varnum-Finney, B.2    Bernstein, I.D.3
  • 13
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: a simple pathway becomes complex
    • 10.1038/nrm2009, 16921404
    • Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006, 7:678-689. 10.1038/nrm2009, 16921404.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 14
  • 15
    • 34248382155 scopus 로고    scopus 로고
    • Regulating the Notch pathway in embryonic, adult and old stem cells
    • 10.1016/j.coph.2007.02.004, 17475556
    • Carlson ME, Conboy IM. Regulating the Notch pathway in embryonic, adult and old stem cells. Curr Opin Pharmacol 2007, 7:303-309. 10.1016/j.coph.2007.02.004, 17475556.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 303-309
    • Carlson, M.E.1    Conboy, I.M.2
  • 17
    • 11844301282 scopus 로고    scopus 로고
    • Medulloblastoma: developmental mechanisms out of control
    • 10.1016/j.molmed.2004.11.008, 15649818
    • Marino S. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 2005, 11:17-22. 10.1016/j.molmed.2004.11.008, 15649818.
    • (2005) Trends Mol Med , vol.11 , pp. 17-22
    • Marino, S.1
  • 18
    • 0033193157 scopus 로고    scopus 로고
    • The Notch-Hes pathway in mammalian neural development
    • 10.1038/sj.cr.7290016, 10520600
    • Kageyama R, Ohtsuka T. The Notch-Hes pathway in mammalian neural development. Cell Res 1999, 9:179-188. 10.1038/sj.cr.7290016, 10520600.
    • (1999) Cell Res , vol.9 , pp. 179-188
    • Kageyama, R.1    Ohtsuka, T.2
  • 20
    • 34547603970 scopus 로고    scopus 로고
    • The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1
    • 10.1093/carcin/bgm092, 17434929
    • Liao WR, Hsieh RH, Hsu KW, Wu MZ, Tseng MJ, Mai RT, Wu Lee YH, Yeh TS. The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1. Carcinogenesis 2007, 28:1867-1876. 10.1093/carcin/bgm092, 17434929.
    • (2007) Carcinogenesis , vol.28 , pp. 1867-1876
    • Liao, W.R.1    Hsieh, R.H.2    Hsu, K.W.3    Wu, M.Z.4    Tseng, M.J.5    Mai, R.T.6    Wu Lee, Y.H.7    Yeh, T.S.8
  • 21
    • 0035856467 scopus 로고    scopus 로고
    • Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate
    • 10.1016/S0960-9822(01)00562-0, 11719214
    • Ramain P, Khechumian K, Seugnet L, Arbogast N, Ackermann C, Heitzler P. Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr Biol 2001, 11:1729-1738. 10.1016/S0960-9822(01)00562-0, 11719214.
    • (2001) Curr Biol , vol.11 , pp. 1729-1738
    • Ramain, P.1    Khechumian, K.2    Seugnet, L.3    Arbogast, N.4    Ackermann, C.5    Heitzler, P.6
  • 23
    • 33644617191 scopus 로고    scopus 로고
    • Loss of notch activity in the developing central nervous system leads to increased cell death
    • 10.1159/000090752, 16508303
    • Mason HA, Rakowiecki SM, Gridley T, Fishell G. Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci 2006, 28:49-57. 10.1159/000090752, 16508303.
    • (2006) Dev Neurosci , vol.28 , pp. 49-57
    • Mason, H.A.1    Rakowiecki, S.M.2    Gridley, T.3    Fishell, G.4
  • 24
    • 7444224783 scopus 로고    scopus 로고
    • Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    • 10.1158/0008-5472.CAN-04-1446, 15520184
    • Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D, Brat DJ, Perry A, Eberhart CG. Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res 2004, 64:7787-7793. 10.1158/0008-5472.CAN-04-1446, 15520184.
    • (2004) Cancer Res , vol.64 , pp. 7787-7793
    • Fan, X.1    Mikolaenko, I.2    Elhassan, I.3    Ni, X.4    Wang, Y.5    Ball, D.6    Brat, D.J.7    Perry, A.8    Eberhart, C.G.9
  • 25
    • 0842334506 scopus 로고    scopus 로고
    • Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells
    • 10.1002/jnr.10843, 14743446
    • Irvin DK, Nakano I, Paucar A, Kornblum HI. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. J Neurosci Res 2004, 75:330-343. 10.1002/jnr.10843, 14743446.
    • (2004) J Neurosci Res , vol.75 , pp. 330-343
    • Irvin, D.K.1    Nakano, I.2    Paucar, A.3    Kornblum, H.I.4
  • 26
    • 33748542296 scopus 로고    scopus 로고
    • Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice
    • 10.1007/s11060-006-9132-2, 16598417
    • Dakubo GD, Mazerolle CJ, Wallace VA. Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice. J Neurooncol 2006, 79:221-227. 10.1007/s11060-006-9132-2, 16598417.
    • (2006) J Neurooncol , vol.79 , pp. 221-227
    • Dakubo, G.D.1    Mazerolle, C.J.2    Wallace, V.A.3
  • 28
    • 0025815911 scopus 로고
    • Role of the Drosophila patched gene in positional signalling
    • 10.1038/353184a0, 1653906
    • Ingham PW, Taylor AM, Nakano Y. Role of the Drosophila patched gene in positional signalling. Nature 1991, 353:184-187. 10.1038/353184a0, 1653906.
    • (1991) Nature , vol.353 , pp. 184-187
    • Ingham, P.W.1    Taylor, A.M.2    Nakano, Y.3
  • 29
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: paradigms and principles
    • 10.1101/gad.938601, 11731473
    • Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001, 15:3059-3087. 10.1101/gad.938601, 11731473.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 30
    • 33644509505 scopus 로고    scopus 로고
    • Patched1 functions as a gatekeeper by promoting cell cycle progression
    • 10.1158/0008-5472.CAN-05-2146, 16489008
    • Adolphe C, Hetherington R, Ellis T, Wainwright B. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res 2006, 66:2081-2088. 10.1158/0008-5472.CAN-05-2146, 16489008.
    • (2006) Cancer Res , vol.66 , pp. 2081-2088
    • Adolphe, C.1    Hetherington, R.2    Ellis, T.3    Wainwright, B.4
  • 31
    • 0032585515 scopus 로고    scopus 로고
    • Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
    • 10.1038/25533, 9874371
    • Ohlmeyer JT, Kalderon D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 1998, 396:749-753. 10.1038/25533, 9874371.
    • (1998) Nature , vol.396 , pp. 749-753
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 32
    • 0037155737 scopus 로고    scopus 로고
    • Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
    • 10.1016/S0092-8674(02)00664-5, 11955435
    • Price MA, Kalderon D. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 2002, 108:823-835. 10.1016/S0092-8674(02)00664-5, 11955435.
    • (2002) Cell , vol.108 , pp. 823-835
    • Price, M.A.1    Kalderon, D.2
  • 33
    • 30044442183 scopus 로고    scopus 로고
    • Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb
    • 10.1016/j.cub.2005.12.012, 16386907
    • Smelkinson MG, Kalderon D. Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr Biol 2006, 16:110-116. 10.1016/j.cub.2005.12.012, 16386907.
    • (2006) Curr Biol , vol.16 , pp. 110-116
    • Smelkinson, M.G.1    Kalderon, D.2
  • 34
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    • 10.1016/j.devcel.2005.01.001, 15691767
    • Zhang W, Zhao Y, Tong C, Wang G, Wang B, Jia J, Jiang J. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell 2005, 8:267-278. 10.1016/j.devcel.2005.01.001, 15691767.
    • (2005) Dev Cell , vol.8 , pp. 267-278
    • Zhang, W.1    Zhao, Y.2    Tong, C.3    Wang, G.4    Wang, B.5    Jia, J.6    Jiang, J.7
  • 35
    • 77953767906 scopus 로고    scopus 로고
    • Canonical Notch signaling is not required for the growth of Hedgehog pathway induced medulloblastoma
    • 10.1038/onc.2010.101, 20418906
    • Julian E, Dave RK, Robson JP, Hallahan AR, Wainwright BJ. Canonical Notch signaling is not required for the growth of Hedgehog pathway induced medulloblastoma. Oncogene 2010, 29:3465-3476. 10.1038/onc.2010.101, 20418906.
    • (2010) Oncogene , vol.29 , pp. 3465-3476
    • Julian, E.1    Dave, R.K.2    Robson, J.P.3    Hallahan, A.R.4    Wainwright, B.J.5
  • 36
    • 33645002415 scopus 로고    scopus 로고
    • Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis
    • 10.1016/j.canlet.2005.03.047, 15925443
    • Pazzaglia S. Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis. Cancer Lett 2006, 234:124-134. 10.1016/j.canlet.2005.03.047, 15925443.
    • (2006) Cancer Lett , vol.234 , pp. 124-134
    • Pazzaglia, S.1
  • 40
    • 77749336752 scopus 로고    scopus 로고
    • Essential roles of notch signaling in maintenance of neural stem cells in developing and adult brains
    • 10.1523/JNEUROSCI.4987-09.2010, 20203209
    • Imayoshi I, Sakamoto M, Yamaguchi M, Mori K, Kageyama R. Essential roles of notch signaling in maintenance of neural stem cells in developing and adult brains. J Neurosci 2010, 30:3489-3498. 10.1523/JNEUROSCI.4987-09.2010, 20203209.
    • (2010) J Neurosci , vol.30 , pp. 3489-3498
    • Imayoshi, I.1    Sakamoto, M.2    Yamaguchi, M.3    Mori, K.4    Kageyama, R.5
  • 41
    • 39849098719 scopus 로고    scopus 로고
    • Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling
    • 10.1038/sj.onc.1210767, 17873912
    • Ingram WJ, McCue KI, Tran TH, Hallahan AR, Wainwright BJ. Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. Oncogene 2007, 27:1489-1500. 10.1038/sj.onc.1210767, 17873912.
    • (2007) Oncogene , vol.27 , pp. 1489-1500
    • Ingram, W.J.1    McCue, K.I.2    Tran, T.H.3    Hallahan, A.R.4    Wainwright, B.J.5
  • 42
    • 59849104344 scopus 로고    scopus 로고
    • Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity
    • 10.1083/jcb.200805155, 2615087, 19124651
    • Wall DS, Mears AJ, McNeill B, Mazerolle C, Thurig S, Wang Y, Kageyama R, Wallace VA. Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 2009, 184:101-112. 10.1083/jcb.200805155, 2615087, 19124651.
    • (2009) J Cell Biol , vol.184 , pp. 101-112
    • Wall, D.S.1    Mears, A.J.2    McNeill, B.3    Mazerolle, C.4    Thurig, S.5    Wang, Y.6    Kageyama, R.7    Wallace, V.A.8
  • 43
    • 0036023380 scopus 로고    scopus 로고
    • Notch1 is required for neuronal and glial differentiation in the cerebellum
    • Lutolf S, Radtke F, Aguet M, Suter U, Taylor V. Notch1 is required for neuronal and glial differentiation in the cerebellum. Development 2002, 129:373-385.
    • (2002) Development , vol.129 , pp. 373-385
    • Lutolf, S.1    Radtke, F.2    Aguet, M.3    Suter, U.4    Taylor, V.5
  • 44
    • 33644610874 scopus 로고    scopus 로고
    • Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia
    • 10.1159/000090754, 16508305
    • Weller M, Krautler N, Mantei N, Suter U, Taylor V. Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia. Dev Neurosci 2006, 28:70-80. 10.1159/000090754, 16508305.
    • (2006) Dev Neurosci , vol.28 , pp. 70-80
    • Weller, M.1    Krautler, N.2    Mantei, N.3    Suter, U.4    Taylor, V.5
  • 45
    • 2442720109 scopus 로고    scopus 로고
    • Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization
    • 10.1038/sj.onc.1207475, 15064731
    • Yokota N, Mainprize TG, Taylor MD, Kohata T, Loreto M, Ueda S, Dura W, Grajkowska W, Kuo JS, Rutka JT. Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 2004, 23:3444-3453. 10.1038/sj.onc.1207475, 15064731.
    • (2004) Oncogene , vol.23 , pp. 3444-3453
    • Yokota, N.1    Mainprize, T.G.2    Taylor, M.D.3    Kohata, T.4    Loreto, M.5    Ueda, S.6    Dura, W.7    Grajkowska, W.8    Kuo, J.S.9    Rutka, J.T.10
  • 46
    • 34548825987 scopus 로고    scopus 로고
    • Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
    • 10.1038/nature06090, 17721509
    • Mizutani KI, Yoon K, Dang L, Tokunaga A, Gaiano N. Differential Notch signalling distinguishes neural stem cells from intermediate progenitors. Nature 2007, 449:351-355. 10.1038/nature06090, 17721509.
    • (2007) Nature , vol.449 , pp. 351-355
    • Mizutani, K.I.1    Yoon, K.2    Dang, L.3    Tokunaga, A.4    Gaiano, N.5
  • 48
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • 10.1158/0008-5472.CAN-06-0858, 16885340
    • Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM, Eberhart CG. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006, 66:7445-7452. 10.1158/0008-5472.CAN-06-0858, 16885340.
    • (2006) Cancer Res , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.M.6    Eberhart, C.G.7
  • 49
    • 65549140334 scopus 로고    scopus 로고
    • Notch inhibitors as a new tool in the war on cancer: a pathway to watch
    • 10.2174/138920109787315060, 19199947
    • Purow B. Notch inhibitors as a new tool in the war on cancer: a pathway to watch. Curr Pharm Biotechnol 2009, 10:154-160. 10.2174/138920109787315060, 19199947.
    • (2009) Curr Pharm Biotechnol , vol.10 , pp. 154-160
    • Purow, B.1


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