Opposite effects of two nonstructural proteins of Theiler's murine encephalomyelitis virus regulates apoptotic cell death in BHK-21 cells

Microbiology and Immunology

Volumn 54, Issue 10, 2010, Pages 639-643

  Okuwa, Takako ^a   Taniura, Naoko ^a   Saito, Mineki ^a   Himeda, Toshiki ^a   Ohara, Yoshiro ^a  

^a KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Leader protein, L* protein; Theiler's murine encephalomyelitis virus

Indexed keywords

LEADER PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; CELL LINE; CRICETINAE; THEILOVIRUS; VIRAL NONSTRUCTURAL PROTEINS;

THEILER'S ENCEPHALOMYELITIS VIRUS;

EID: 77957892827     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2010.00260.x     Document Type: Article

References (29)

1. Oleszak E.L., Chang J.R., Friedman H., Katsetos C.D., Platsoucas C.D. (2004) Theiler's virus infection: a model for multiple sclerosis. Clin Microbiol Rev 17: 174-207.
2. Roos R.P. (2010) Pathogenesis of Theiler's murine encephalomyelitis virus-induces disease. Clin Exp Neuroimmunol (doi: 10.1111/j.1759-1961.2010.00008.x).
3. Takano-Maruyama M., Ohara Y., Asakura K., Okuwa T. (2006) Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities. J Neuroinflammation 3: 19.
4. Law K.M., Brown T.D.K. (1990) The complete nucleotide sequence of the GDVII strain of Theiler's murine encephalomyelitis virus (TMEV). Nucl Acid Res 18: 6707-08.
5. Ohara Y., Stein S., Fu J., Stillman L., Klaman L., Roos R.P. (1988) Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses. Virology 164: 245-55.
6. Fan J., Son K.-N., Arslan S.Y., Liang Z., Lipton H.L. (2009) Theiler's murine encephalomyelitis virus leader protein is the only nonstructural protein tested that induces apoptosis when transfected into mammalian cells. J Virol 83: 6546-53.
7. KongW.P. Roos R.P. (1991) Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus. J Virol 65: 3395-99.
8. Ghadge G.D., Ma L., Sato S., Kim J., Roos R.P. (1998) A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence. J Virol 72: 8605-12.
9. Himeda T., Ohara Y., Asakura K., Kontani Y., Sawada M. (2005) A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) has an anti-apoptotic effect in a macrophage cell line. Microb Pathog 38: 201-7.
10. Tsunoda I., Kurtz C.I.B., Fujinami R.S. (1997) Apoptosis in acute and chronic central nervous system disease induced by Theiler's murine encephalomyelitis virus. Virology 228: 388-93.
11. Son K.-N., Pugazhenthi S., Lipton H.L. (2009) Activation of tumor suppressor protein p53 is required for Theiler's murine encephalomyelitis virus-induced apoptosis in M1-D macrophages. J Virol 83: 10770-77.
12. Jelachich M.L., Bramlage C., Lipton H.L. (1999) Differentiation of M1 myeloid precursor cells into macrophages results in binding and infection by Theiler's murine encephalomyelitis virus and apoptosis. J Virol 73: 3227-35.
13. Jelachich M.L., Lipton H.L. (2001) Theiler's murine encephalomyelitis virus induces apoptosis in gamma interferon-activated M1 differentiated myelomonocytic cells through a mechanism involving tumor necrosis factor alpha (TNF-α) and TNF-α-related apoptosis-inducing ligand. J Virol 75: 5930-38.
14. + T cell-mediated apoptosis of activated astrocytes in Theiler's virus-induced demyelination. J Immunol 162: 6543-51.
15. Rubio N., Martin-Clemente B., Lipton H.L. (2003) High-neurovirulence GDVII virus induces apoptosis in murine astrocytes through tumor necrosis factor (TNF)-receptor and TNF-related apoptosis-inducing ligand. Virology 311: 366-75.
16. Ohara Y., Himeda T., Asakura K., Sawada M. (2002) Distinct cell death mechanisms by Theiler's murine encephalomyelitis virus (TMEV) infection in microglia and macrophage. Neurosci Lett 327: 41-44.
17. Oleszak E.L., Hoffman B.E., Chang J.R., Zaczynska E., Gaughan J., Katsetos C.D., Platsoucas C.D., Harvey N. (2003) Apoptosis of infiltrating T cells in the central nervous system of mice infected with Theiler's murine encephalomyelitis virus. Virology 315: 110-23.
18. Clatch R.J., Miller S.D., Metzner R., Dal Canto M.C., Lipton H.L. (1990) Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virology 176: 244-54.
19. Lipton H.L., Twaddle G., Jelachich M.L. (1995) The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Virol 69: 2525-33.
20. Rossi C.P., Delcroix M., Huitinga I., McAllister A., van Rooijen N., Claassen E., Brahic M. (1997) Role of macrophages during Theiler's virus infection. J Virol 71: 3336-40.
21. Delhaye S., van Pesch V., Michiels T. (2004) The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins. J Virol 78: 4357-62.
22. Calenoff M.A., Badshah C.S., Dal Canto M.C., Lipton H.L., Rundell M.K. (1995) The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells. J Virol 69: 5544-49.
23. van Pesch V., van Eyll O., Michiels T. (2001) The leader protein of Theiler's virus inhibits immediate-early alpha/beta interferon production. J Virol 75: 7811-17.
24. Badshah C., Calenoff M.A., Rundell K. (2000) The leader polypeptide of Theiler's murine encephalomyelitis virus is required for the assembly of virions in mouse L cells. J Virol 74: 875-82.
25. Takano-Maruyama M., Ohara Y., Asakura K., Okuwa T. (2006) Theiler's murine encephalomyelitis virus leader protein amino acid residue 57 regulates subgroup-specific virus growth on BHK-21 cells. J Virol 80: 12025-31.
26. Himeda T., Ohara Y., Asakura K., Kontani Y., Murakami M., Suzuki H., Sawada M. (2005) A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage-like cell line. Virus Res 108: 23-28.
27. Obuchi M., Yamamoto J., Uddin N., Odagiri T., Iizuka H., Ohara Y. (1999) Theiler's murine encephalomyelitis virus (TMEV) subgroup strain-specific infection in neural and non-neural cell lines. Microbiol Immunol 43: 885-92.
28. TakataH., Obuchi M., Yamamoto J., Odagiri T., Roos R. P. Iizuka H., Ohara Y. (1998) L* protein of the DA strain of Theiler's murine encephalomyelitis virus is important for virus growth in a murine macrophage-like cell line. J Virol 72: 4950-55.
29. Ichinose-Asakura K., Taniura N., Himeda T., Nojiri M., Okuwa T., Ohara Y. (2010) Leader (L) of Theiler's murine encephalomyelitis virus (TMEV) is required for virus growth in a murine macrophage-like cell line. Virus Res 147: 224-30.