Role of Candida albicans Aft2p transcription factor in ferric reductase activity, morphogenesis and virulence

Microbiology

Volumn 156, Issue 10, 2010, Pages 2912-2919

  Liang, Yong ^a   Wei, Dongsheng ^a   Wang, Hui ^a   Xu, Ning ^a   Zhang, Biao ^b   Xing, Laijun ^a   Li, Mingchun ^a  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IRON REDUCTASE; OXIDOREDUCTASE; PROTEIN AFT 2 P; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA ALBICANS; CELL GROWTH; ENZYME ACTIVITY; FUNGUS HYPHAE; GENE DELETION; MOLECULAR CLONING; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE; VIRULENCE;

ANIMALS; CANDIDA ALBICANS; CLONING, MOLECULAR; FEMALE; FMN REDUCTASE; FUNGAL PROTEINS; GENETIC COMPLEMENTATION TEST; MICE; MICE, INBRED ICR; MUTATION; SACCHAROMYCES CEREVISIAE; SESQUITERPENES; TRANSCRIPTION FACTORS; VIRULENCE;

CANDIDA ALBICANS; SACCHAROMYCES CEREVISIAE;

EID: 77957885164     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.037978-0     Document Type: Article

References (31)

1. Almeida, R. S., Wilson, D. & Hube, B. (2009). Candida albicans iron acquisition within the host. FEMS Yeast Res 9, 1000-1012.
2. Baek, Y. U., Li, M. & Davis, D. A. (2008). Candida albicans ferric reductases are differentially regulated in response to distinct forms of iron limitation by the Rim101 and CBF transcription factors. Eukaryot Cell 7, 1168-1179.
3. Banerjee, M., Thompson, D. S., Lazzell, A., Carlisle, P. L., Pierce, C., Monteagudo, C., López-Ribot, J. L. & Kadosh, D. (2008). UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence. Mol Biol Cell 19, 1354-1365.
4. Barelle, C. J., Priest, C. L., MacCallum, D. M., Gow, N. A. R., Odds, F. C. & Brown, A. J. P. (2006). Niche-specific regulation of central metabolic pathways in a fungal pathogen. Cell Microbiol 8, 961-971.
5. Berman, J. (2006). Morphogenesis and cell cycle progression in Candida albicans. Curr Opin Microbiol 9, 595-601.
6. Biswas, S., Van, D. P. & Datta, A. (2007). Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans. Microbiol Mol Biol Rev 71, 348-376.
7. Blaiseau, P. L., Lesuisse, E. & Camadro, J. M. (2001). Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276, 34221-34226.
8. Byers, B. R. & Arceneaux, J. E. L. (1998). Microbial iron transport: iron acquisition by pathogenic microorganisms. Met Ions Biol Syst 35, 37-66.
9. Cao, F., Lane, S., Raniga, P. P., Lu, Y., Zhou, Z., Ramon, K., Chen, J. & Liu, H. (2006). The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans. Mol Biol Cell 17, 295-307.
10. Carlisle, P. L., Banerjee, M., Lazzell, A., Monteagudo, C., Lopez-Ribot, J. L. & Kadosh, D. (2009). Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence. Proc Natl Acad Sci U S A 106, 599-604.
11. Casas, C., Aldea, M., Espinet, C., Gallego, C., Gil, R. & Herrero, E. (1997). The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae. Yeast 13, 621-643.
12. Courel, M., Lallet, S., Camadro, J. M. & Blaiseau, P. L. (2005). Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25, 6760-6771.
13. Davis, D., Edwards, J. E., Jr, Mitchell, A. P. & Ibrahim, A. S. (2000a). Candida albicans RIM101 pH response pathway is required for host-pathogen interactions. Infect Immun 68, 5953-5959.
14. Davis, D., Wilson, R. B. & Mitchell, A. P. (2000b). RIM101-dependent and-independent pathways govern pH responses in Candida albicans. Mol Cell Biol 20, 971-978.
15. Doedt, T., Krishnamurthy, S., Bockmühl, D. P. B., Tebarth, B., Stempel, C., Russel, C. L., Brown, A. J. P. & Ernst, J. F. (2004). APSES proteins regulate morphogenesis and metabolism in Candida albicans. Mol Biol Cell 15, 3167-3180.
16. Homann, O. R., Dea, J., Noble, S. M. & Johnson, A. D. (2009). A phenotypic profile of the Candida albicans regulatory network. PLoS Genet 5, e1000783.
17. Klepser, M. E. (2006). Candida resistance and its clinical relevance. Pharmacotherapy 26, 68S-75S.
18. Knight, S. A., Vilaire, G., Lesuisse, E. & Dancis, A. (2005). Iron acquisition from transferrin by Candida albicans depends on the reductive pathway. Infect Immun 73, 5482-5492.
19. Lan, C. Y., Rodarte, G., Murillo, L. A., Jones, T., Davis, R. W., Dungan, J., Newport, G. & Agabian, N. (2004). Regulatory networks affected by iron availability in Candida albicans. Mol Microbiol 53, 1451-1469.
20. Liang, Y., Gui, L., Wei, D.-S., Zheng, W., Xing, L.-J. & Li, M.-C. (2009). Candida albicans ferric reductase FRP1 is regulated by direct interaction with Rim101p transcription factor. FEMS Yeast Res 9, 270-277.
21. Liu, H., Köhler, J. & Fink, G. R. (1994). Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266, 1723-1726.
22. Lo, H. J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A. & Fink, G. R. (1997). Nonfilamentous C. albicans mutants are avirulent. Cell 90, 939-949.
23. Mitchell, P. J. & Tjian, R. (1989). Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245, 371-378.
24. Murad, A. M. A., d'Enfert, C., Gaillardin, C., Tournu, L., Tekaia, F., Talibi, D., Marechal, D., Marchais, V., Cottin, J. & Brown, A. J. P. (2001). Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1. Mol Microbiol 42, 981-993.
25. Philpott, C. C. & Protchenko, O. (2008). Response to iron deprivation in Saccharomyces cerevisiae. Eukaryot Cell 7, 20-27.
26. Ramanan, N. & Wang, Y. (2000). A high-affinity iron permease essential for Candida albicans virulence. Science 288, 1062-1064.
27. Rutherford, J. C., Jaron, S., Ray, E., Brown, P. O. & Winge, D. R. (2001). A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A 98, 14322-14327.
28. Rutherford, J. C., Jaron, S. & Winge, D. R. (2003). Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem 278, 27636-27643.
29. Thomas, B. J. & Rothstein, R. (1989). Elevated recombination rates in transcriptionally active DNA. Cell 56, 619-630.
30. Wilson, R. B., Davis, D. & Mitchell, A. P. (1999). Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J Bacteriol 181, 1868-1874.
31. Yamaguchi-Iwai, Y., Dancis, A. & Klausner, R. D. (1995). AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae. EMBO J 14, 1231-1239.