Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6268-6272

  Scheiper, Bodo ^a   Matter, Hans ^a   Steinhagen, Henning ^a   Stilz, Ulrich ^a   Böcskei, Zsolt ^b   Fleury, Valérie ^b   McCort, Gary ^b  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b SANOFI   (France)

Author keywords

Hypertension; Indole; Renin inhibitors; Structure based design; X ray crystallography

Indexed keywords

AMIDE; INDOLE 3 CARBOXAMIDE DERIVATIVE; RENIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IC 50; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; INDOLES; MODELS, MOLECULAR; PROTEIN CONFORMATION; RENIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957875612     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.092     Document Type: Article

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