Ventral hippocampus, interneurons, and schizophrenia: A new understanding of the pathophysiology of schizophrenia and its implications for treatment and prevention

Current Directions in Psychological Science

Volumn 19, Issue 4, 2010, Pages 232-237

  Grace, Anthony A ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

dopamine; GABA; glutamate; hippocampus; schizophrenia; stress

Indexed keywords

EID: 77957874819     PISSN: 09637214     EISSN: 14678721     Source Type: Journal    
DOI: 10.1177/0963721410378032     Document Type: Article

References (28)

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2. Grace, A.A., Floresco, S.B., Goto, Y., & Lodge, D.J. (2007). (See References). This paper provides an overview of the gain model and how it is related to regulation of behavior.
3. Grace, A.A., & Sesack, S. (2010). The cortico-basal ganglia reward network: Microcircuitry. Neuropsychopharmacology, 35, 4-26. This paper provides an overview of the circuitry of the cortex and basal ganglia as they relate to reward and affect, and how they affect behavior.
4. Lisman, J.E., Coyle, J.T., Greene, R.W., Javitt, D.C., Benes, F.M., Heckers, S., & Grace, A.A. (2008). Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends in Neurosciences, 31, 234-242. A comprehensive paper linking genetic predisposition and cellular network changes as a functional basis for schizophrenia.
5. Lodge, D.J., & Grace, A.A. (2009). Gestational methylazoxymethanol acetate administration: A developmental disruption model of schizophrenia. Behavioral Brain Research, 204, 306-12. An overview of the MAM model of schizophrenia and what a rodent model can tell us about the pathophysiology of schizophrenia in humans.
6. Floresco, S.B., West, A.R., Ash, B., Moore, H., & Grace, A.A. (2003). Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nature Neuroscience, 6, 968-973.
7. Fox, K.M., & Grace, A.A. (2009, October). Peripubertal administration of diazepam prevents dopaminergic pathophysiology in the MAM developmental model of schizophrenia. Poster presented at the annual meeting of the Society for Neuroscience, Chicago, IL.
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19. Lodge, D.J., & Grace, A.A. (2006). The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activation. Neuropsychopharmacology, 31, 1356-1361.
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27. Valenti, O., & Grace, A.A. (2008, November). Acute and repeated stress induce a pronounced and sustained activation of VTA DA neuron population activity. Poster presented at the annual meeting of the Society for Neuroscience, Washington, DC.
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