Neuropeptide Y is a mediator of chronic vascular and metabolic maladaptations to stress and hypernutrition

Experimental Biology and Medicine

Volumn 235, Issue 10, 2010, Pages 1179-1184

  Abe, Ken ^a   Kuo, Lydia ^a   Zukowska, Zofia ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Cardiovascular disease; Metabolic syndrome; Neuropeptide Y; Obesity; Stress

Indexed keywords

CORTICOSTERONE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NORADRENALIN;

ADIPOSE TISSUE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL PROLIFERATION; CHRONIC STRESS; CONFERENCE PAPER; GENE MUTATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIPOLYSIS; MALADJUSTMENT; MEDIATOR RELEASE; METABOLIC DISORDER; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; NUTRITIONAL DISORDER; OBESITY; PROTEIN SECRETION; SYMPATHETIC NERVE; THERMOGENESIS; THROMBOSIS; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOLOGICAL MODEL; CARDIOVASCULAR DISEASES; METABOLIC DISEASES; OVERNUTRITION; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

RODENTIA;

ANIMALS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; HUMANS; METABOLIC DISEASES; MODELS, BIOLOGICAL; NEUROPEPTIDE Y; OBESITY; OVERNUTRITION; STRESS, PHYSIOLOGICAL;

EID: 77957855989     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2010.009136     Document Type: Conference Paper

References (51)

1. Ritchie SA, Connell JM. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis 2007;17:319-26
2. Morris M, Kapoor V, Chalmers J. Plasma neuropeptide Y concentration is increased after hemorrhage in conscious rats: relative contributions of sympathetic nerves and the adrenal medulla. J Cardiovasc Pharmacol 1987;9:541-5 (Pubitemid 17069869)
3. Zukowska-Grojec Z, Konarska M, McCarty R. Differential plasma catecholamine and neuropeptide Y responses to acute stress in rats. Life Sci 1988;42:1615-24
4. Zukowska-Grojec Z, Vaz AC. Role of neuropeptide Y (NPY) in cardiovascular responses to stress. Synapse 1988;2:293-8
5. Tatemoto K. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 1982;79:5485-9
6. Fallgren B, Arlock P, Edvinsson L. Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction by an intracellular calcium-dependent mechanism. J Auton Nerv Syst 1993;44:151-9 (Pubitemid 23272998)
7. Pons J, Kitlinska J, Ji H, Lee EW, Zukowska Z. Mitogenic actions of neuropeptide Y in vascular smooth muscle cells: synergetic interactions with the beta-adrenergic system. Can J Physiol Pharmacol 2003;81:177-85 (Pubitemid 36398892)
8. Pons J, Lee EW, Li L, Kitlinska J. Neuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases. Curr Opin Invest Drugs 2004;5:957-62
9. Zukowska-Grojec Z, Pruszczyk P, Colton C, Yao J, Shen GH, Myers AK, Wahlestedt C. Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. Peptides 1993;14:263-8
10. Erlinge D, Brunkwall J, Edvinsson L. Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP. Regul Pept 1994;50:259-65
11. Nie M, Selbie LA. Neuropeptide Y Y1 and Y2 receptor-mediated stimulation of mitogen-activated protein kinase activity. Regul Pept 1998;75-76:207-13
12. Li L, Jonsson-Rylander AC, Abe K, Zukowska Z. Chronic stress induces rapid occlusion of angioplasty-injured rat carotid artery by activating neuropeptide Y and its Y1 receptors. Arterioscler Thromb Vasc Biol 2005;25:2075-80
13. Li L, Lee EW, Ji H, Zukowska Z. Neuropeptide Y-induced acceleration of postangioplasty occlusion of rat carotid artery. Arterioscler Thromb Vasc Biol 2003;23:1204-10
14. Zukowska-Grojec Z. Neuropeptide Y. A novel sympathetic stress hormone and more. Ann NY Acad Sci 1995;771:219-33
15. Allen JM, Schon F, Yeats JC, Kelly JS, Bloom SR. Effect of reserpine, phenoxybenzamine and cold stress on the neuropeptide Y content of the rat peripheral nervous system. Neuroscience 1986;19:1251-4
16. Castagne V, Corder R, Gaillard R, Mormede P. Stress-induced changes of circulating neuropeptide Y in the rat: comparison with catecholamines. Regul Pept 1987;19:55-63
17. Kuo LE, Kitlinska JB, Tilan JU, Li L, Baker SB, Johnson MD, Lee EW, Burnett MS, Fricke ST, Kvetnansky R, Herzog H, Zukowska Z. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 2007;13:803-11
18. Myers AK, Torres Duarte AP, Zukowska-Grojec Z. Immunoreactive neuropeptide Y (NPY) in plasma and platelets of rat and mouse strains and human volunteers. Regul Pept 1993;47:239-45
19. Ericsson A, Larhammar D, McIntyre KR, Persson H. A molecular genetic approach to the identification of genes expressed predominantly in the neuroendocrine and immune systems. Immunol Rev 1987;100:261-77
20. Ericsson A, Schalling M, McIntyre KR, Lundberg JM, Larhammar D, Seroogy K, Hokfelt T, Persson H. Detection of neuropeptide Y and its mRNA in megakaryocytes: enhanced levels in certain autoimmune mice. Proc Natl Acad Sci USA 1987;84:5585-9
21. Bedoui S, Kawamura N, Straub RH, Pabst R, Yamamura T, von Horsten S. Relevance of neuropeptide Y for the neuroimmune crosstalk. J Neuroimmunol 2003;134:1-11
22. Bedoui S, Kuhlmann S, Nave H, Drube J, Pabst R, von Horsten S. Differential effects of neuropeptide Y (NPY) on leukocyte subsets in the blood: mobilization of B-1-like B-lymphocytes and activated monocytes. J Neuroimmunol 2001;117:125-32
23. Straub RH, Mayer M, Kreutz M, Leeb S, Scholmerich J, Falk W. Neurotransmitters of the sympathetic nerve terminal are powerful chemoattractants for monocytes. J Leukocyte Biol 2000;67:553-8
24. Schwarz H, Villiger PM, von Kempis J, Lotz M. Neuropeptide Y is an inducible gene in the human immune system. J Neuroimmunol 1994;51:53-61
25. Wheway J, Herzog H, Mackay F. The Y(1) receptor for NPY: a key modulator of the adaptive immune system. Peptides 2007;28:453-8
26. Ekstrand AJ, Cao R, Bjorndahl M, Nystrom S, Jonsson-Rylander AC, Hassani H, Hallberg B, Nordlander M, Cao Y. Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing. Proc Natl Acad Sci USA 2003;100:6033-8
27. Grant DS, Zukowska Z. Revascularization of ischemic tissues with SIKVAV and neuropeptide Y (NPY). Adv Exp Med Biol 2000;476:139-54
28. Lee EW, Grant DS, Movafagh S, Zukowska Z. Impaired angiogenesis in neuropeptide Y (NPY)-Y2 receptor knockout mice. Peptides 2003;24:99-106
29. Lee EW, Michalkiewicz M, Kitlinska J, Kalezic I, Switalska H, Yoo P, Sangkharat A, Ji H, Li L, Michalkiewicz T, Ljubisavljevic M, Johansson H, Grant DS, Zukowska Z. Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. J Clin Invest 2003;111:1853-62
30. Movafagh S, Hobson JP, Spiegel S, Kleinman HK, Zukowska Z. Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors. FASEB J 2006;20:1924-6
31. Zukowska-Grojec Z, Karwatowska-Prokopczuk E, Rose W, Rone J, Movafagh S, Ji H, Yeh Y, Chen WT, Kleinman HK, Grouzmann E, Grant DS. Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. Circ Res 1998;83:187-95 (Pubitemid 28354463)
32. Ericsson A, Hemsen A, Lundberg JM, Persson H. Detection of neuropeptide Y-like immunoreactivity and messenger RNA in rat platelets: the effects of vinblastine, reserpine, and dexamethasone on NPY expression in blood cells. Exp Cell Res 1991;192:604-11 (Pubitemid 121006980)
33. Hemsen A, Pernow J, Millberg BI, Lundberg JM. Effects of vinblastine on neuropeptide Y levels in the sympathoadrenal system, bone marrow and thrombocytes of the rat. Agents Actions 1991;34:429-38
34. Tabarowski Z, Gibson-Berry K, Felten SY. Noradrenergic and peptidergic innervation of the mouse femur bone marrow. Acta Histochem 1996;98:453-7 (Pubitemid 26401003)
35. Bedoui S, von Horsten S, Gebhardt T. A role for neuropeptide Y (NPY) in phagocytosis: implications for innate and adaptive immunity. Peptides 2007;28:373-6 (Pubitemid 46176264)
36. Shah SH, Freedman NJ, Zhang L, Crosslin DR, Stone DH, Haynes C, Johnson J, Nelson S, Wang L, Connelly JJ, Muehlbauer M, Ginsburg GS, Crossman DC, Jones CJ, Vance J, Sketch MH, Granger CB, Newgard CB, Gregory SG, Goldschmidt-Clermont PJ, Kraus WE, Hauser ER. Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. PLoS Genet 2009;5:e1000318
37. Karvonen MK, Valkonen VP, Lakka TA, Salonen R, Koulu M, Pesonen U, Tuomainen TP, Kauhanen J, Nyyssonen K, Lakka HM, Uusitupa MI, Salonen JT. Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men. Atherosclerosis 2001;159:145-51
38. Ruohonen ST, Abe K, Kero M, Toukola L, Ruohonen S, Roytta M, Koulu M, Pesonen U, Zukowska Z, Savontaus E. Sympathetic nervous system-targeted neuropeptide Y overexpression in mice enhances neointimal formation in response to vascular injury. Peptides 2009;30:715-20
39. Torres SJ, Nowson CA. Relationship between stress, eating behavior, and obesity. Nutrition 2007;23:887-94
40. Turtzo LC, Lane MD. Completing the loop: neuron-adipocyte interactions and the control of energy homeostasis. Horm Metab Res 2002;34:607-15
41. Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol Res 2006;53:482-91 (Pubitemid 43767551)
42. Robidoux J, Martin TL, Collins S. Beta-adrenergic receptors and regulation of energy expenditure: a family affair. Annu Rev Pharmacol Toxicol 2004;44:297-323 (Pubitemid 38263843)
43. Lavebratt C, Alpman A, Persson B, Arner P, Hoffstedt J. Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men. Int J Obes (Lond) 2006;30:453-9
44. Combettes M, Kargar C. Newly approved and promising antidiabetic agents. Therapie 2007;62:293-310
45. Han S, Chen X, Cox B, Yang CL, Wu YM, Naes L, Westfall T. Role of neuropeptide Y in cold stress-induced hypertension. Peptides 1998;19:351-8
46. Han S, Yang CL, Chen X, Naes L, Cox BF, Westfall T. Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction. Am J Physiol 1998;274:H290-4
47. Dark J, Pelz KM. NPY Y1 receptor antagonist prevents NPY-induced torpor-like hypothermia in cold-acclimated Siberian hamsters. Am J Physiol Regul Integr Comp Physiol 2008;294:R236-45
48. Gluck EF, Stephens N, Swoap SJ. Peripheral ghrelin deepens torpor bouts in mice through the arcuate nucleus neuropeptide Y signaling pathway. Am J Physiol Regul Integr Comp Physiol 2006;291:R1303-9
49. Kallio J, Pesonen U, Karvonen MK, Kojima M, Hosoda H, Kangawa K, Koulu M. Enhanced exercise-induced GH secretion in subjects with Pro7 substitution in the prepro-NPY. J Clin Endocrinol Metab 2001;86:5348-52
50. Kos K, Harte AL, James S, Snead DR, O'Hare JP, McTernan PG, Kumar S. Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass. Am J Physiol 2007;293:E1335-40
51. Yang K, Guan H, Arany E, Hill DJ, Cao X. Neuropeptide Y is produced in visceral adipose tissue and promotes proliferation of adipocyte precursor cells via the Y1 receptor. FASEB J 2008;22:2452-64