C-Maf and you won't see fat

Journal of Clinical Investigation

Volumn 120, Issue 10, 2010, Pages 3440-3442

  McCauley, Laurie K ^a,b  

^a UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; LEUCINE ZIPPER PROTEIN; OSTEOCALCIN; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR RUNX2; MAF PROTEIN, MOUSE; RUNX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR C MAF;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; BONE DENSITY; BONE DISEASE; CELL DIFFERENTIATION; GENE EXPRESSION; HUMAN; MOUSE; NONHUMAN; NOTE; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; ADIPOGENESIS; ANIMAL; CELL LINEAGE; CYTOLOGY; MESENCHYMAL STROMA CELL; PHYSIOLOGY;

ADIPOGENESIS; AGING; ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; MESENCHYMAL STEM CELLS; MICE; OSTEOBLASTS; OSTEOPOROSIS; PROTO-ONCOGENE PROTEINS C-MAF; MESENCHYMAL STROMAL CELLS;

EID: 77957837069     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI44786     Document Type: Note

References (20)

1. NIH Osteoporosis and Related Bone Diseases National Resource Center. Osteoporosis Overview Web Site. http://www.niams.nih.gov/Health-Info/Bone/ Osteoporosis/. Accessed August 17, 2010.
2. Compston JE. Osteoporosis: social and economic impact. Radiol Clin North Am. 2010;48(3):477-482.
3. Bianco P, Robey PG, Simmons PJ. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell. 2010;2(4):313-319.
4. Kawai M, Sousa KM, MacDougald OA, Rosen CJ. The many facets of PPARγ: novel insights for the skeleton. Am J Physiol Endocrinol Metab. 2010;299(1):E3-E9.
5. Akune T, et al. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113(6):846-855. (Pubitemid 38544143)
6. Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, MacDougald OA. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem. 2007;282(19):14515-14524.
7. Takada I, Kouzmenko AP, Kato S. Wnt and PPARg signaling in osteoblastogenesis and adipogenesis. Nat Rev Rheumatol. 2009;5(8):442-447.
8. Tokuzawa Y, et al. Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation. PLOS Genetics. 2010;6(7):e1001019.
9. Nishikawa K, et al. Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest. 2010;120(10):3455-3465.
10. Ho IC, Hodge MR, Rooney JW, Glimcher LH. The proto-oncogene c-maf is responsible for tissue- specific expression of interleukin-4. Cell. 1996;85(7):973-983.
11. Kim JI, Li T, Ho IC, Grusby MJ, Glimcher LH. Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. Proc Natl Acad U S A. 1999;96(7):3781-3785.
12. Blank V, Andrews NC. The Maf transcription factors: regulators of differentiation. Trends Biochem Sci. 1997;22(11):437-441. (Pubitemid 27508789)
13. Kataoka K. Multiple mechanisms and functions of Maf transcription factors in the regulation of tissue- specific genes. J Biochem. 2007;141(6):775-781. (Pubitemid 351455334)
14. Wagner EF, Eferl R. Fos/AP-1 proteins in bone and the immune system. Immunol Rev. 2005;208:126-140. (Pubitemid 41746389)
15. Bruedigam C, et al. A new concept underlying stem cell lineage skewing that explains the detrimental effects of thiazolidinediones on bone. Stem Cells. 2010;28(5):916-927.
16. Sen B, Xie Z, Case N, Ma M, Rubin C, Rubin J. Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology. 2008;149(12):6065-6075.
17. Ge C, et al. Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009;284(47):32533-32543.
18. Gimble JM, et al. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol. 1996;50(5):1087-1094.
19. Nuttall ME, Patton AJ, Olivera DL, Nadeau DP, Gowen M. Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: implications for osteopenic disorders. J Bone Miner Res. 1998;13(3):371-382. (Pubitemid 28146219)
20. Undale AH, Westendorf JJ, Yaszemski MJ, Khosla S. Mesenchymal stem cells for bone repair and metabolic bone diseases. Mayo Clin Proc. 2009;84(10):893-902.