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Volumn 45, Issue 11, 2010, Pages 5286-5291
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Synthesis and antitumor activity of novel 6-aryl and 6-alkylpyrazolo[3,4-d] pyrimidin-4-one derivatives
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Author keywords
Antitumor activity; HCT116; Pyrazolo 3,4 d pyrimidin 4 one
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Indexed keywords
3 METHYLSULPHANYL 1 PHENYL 6 ( 2 THIENYL) 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
3 METHYLSULPHANYL 1,6 DIPHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
3 METHYLSULPHANYL 6 ( 3 NITROPHENYL) 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLOL[ 3,4 D]PYRIMIDIN 4 ONE;
3 METHYLSULPHANYL 6 ( 3 NITROPHENYL) 1 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
4 PYRIMIDINONE DERIVATIVE;
6 ( 2 ( 4 METHOXYANILINO)ETHYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 2 ( 4 SULPHONAMIDOANILINO)ETHYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 2 (ANILINO)ETHYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 2 (CYCLOHEXYLAMINO)ETHYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 2 CHLOROETHYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 2 CHLOROPHENYL) 3 METHYLSULPHANYL 1 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 2 HYDROXYPHENYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 2 METHOXYPHENYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 4 CHLOROPHENYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ( 4 CHLOROPHENYL) 3 METHYLSULPHANYL 1 PHENYL 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 (( 4 METHOXYANILINO)METHYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 (( 4 SULPHONAMIDOANILINO)METHYL) 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 CHLOROMETHYL 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
6 ETHYL 3 METHYLSULPHANYL 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLO[ 3,4 D]PYRIMIDIN 4 ONE;
PYRAZOLO[3,4 D]PYRIMIDINE DERIVATIVE;
UNCLASSIFIED DRUG;
ANTINEOPLASTIC ACTIVITY;
ARTICLE;
CELL VIABILITY;
COLON TUMOR;
DRUG POTENCY;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IC 50;
IN VITRO STUDY;
TUMOR CELL;
TUMOR CELL CULTURE;
ANTINEOPLASTIC AGENTS;
CELL LINE, TUMOR;
DRUG SCREENING ASSAYS, ANTITUMOR;
HUMANS;
INHIBITORY CONCENTRATION 50;
MAGNETIC RESONANCE SPECTROSCOPY;
PYRIMIDINONES;
SPECTROPHOTOMETRY, INFRARED;
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EID: 77957826281
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2010.08.048 Document Type: Article |
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Times cited : (34)
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References (11)
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