Thalassemia: The long road from the bedside through the laboratory to the community

Nature Medicine

Volumn 16, Issue 10, 2010, Pages 1112-1115

  Weatherall, David ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLOBIN; HEMOGLOBIN;

GENE MUTATION; GENE STRUCTURE; GENOMICS; GLOBIN GENE; HEMOGLOBIN DETERMINATION; NOTE; PRIORITY JOURNAL; THALASSEMIA; AWARDS AND PRIZES; BIOSYNTHESIS; DEVELOPED COUNTRY; GENETICS; HISTORY; HUMAN; INTERNATIONAL COOPERATION; UNITED KINGDOM;

AWARDS AND PRIZES; DEVELOPED COUNTRIES; GENETICS; GREAT BRITAIN; HEMOGLOBINS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; INTERNATIONAL COOPERATION; THALASSEMIA;

EID: 77957812839     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1010-1112     Document Type: Note

References (11)

1. Weatherall, D.J., Clegg, J.B. & Naughton, M.A. Globin synthesis in thalassaemia: an in vitro study. Nature 208, 1061-1065 (1965).
2. Weatherall, D.J. & Clegg, J.B. The Thalassaemia Syndromes 4th edn. (Blackwell Science, Oxford, 2001).
3. Weatherall, D.J. & Clegg, J.B. The α chain termination mutants and their relationship to thalassaemia. Phil. Trans. R. Soc. Lond. B 271, 411-455 (1975).
4. Weatherall, D.J. et al. Hemoglobin H disease and mental retardation. A new syndrome or a remarkable coincidence? N. Engl. J. Med. 305, 607-612 (1981).
5. Haldane, J.B.S. The rate of mutation of human genes. in Proc. Eighth Int. Congress Genetics. 267-273 (Lund, Sweden, 1949).
6. Allen, S.J. et al. α+-thalassemia protects children against disease due to malaria and other infections. Proc. Natl. Acad. Sci. USA 94, 14736-14741 (1997).
7. O'Donnell, A. et al. Interaction of malaria with a common form of severe thalassemia in an Asian population. Proc. Natl. Acad. Sci. USA 106, 18716-18721 (2009).
8. Weatherall, D.J. Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias. Nat. Rev. Genet. 2, 245-255 (2001).
9. Modell, B. & Darlison, M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull. World Health Organ. 86, 480-487 (2008).
10. Weatherall, D.J. The inherited diseases of hemoglobin are an emerging global health burden. Blood 115, 4331-4336 (2010). World Health Organization.
11. World Health Organization. Genomics and World Health. (WHO, Geneva, 2002).