Pelvic lymphadenectomy during radical cystectomy: A review of the literature

Surgical Oncology

Volumn 19, Issue 4, 2010, Pages 208-220

  Hurle, Rodolfo ^a   Naspro, Richard ^a  

^a Humanitas Gavazzeni Hospital   (Italy)

Author keywords

Bladder cancer; Cystectomy; Extracapsular extension prognosis; Lymph node density; Lymph node dissection; Lymph node metastasis; Lymphadenectomy; Lymphovascular invasion; Transitional cell carcinoma

Indexed keywords

BLADDER CANCER; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CYSTECTOMY; DISEASE FREE SURVIVAL; HUMAN; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; LYMPHATIC DRAINAGE; MEDICAL LITERATURE; MORBIDITY; OVERALL SURVIVAL; PATHOLOGIST; PELVIS LYMPHADENECTOMY; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SURGICAL ANATOMY;

CYSTECTOMY; HUMANS; LYMPH NODE EXCISION; MULTICENTER STUDIES AS TOPIC; NEOPLASM INVASIVENESS; PELVIS; PROGNOSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; URINARY BLADDER NEOPLASMS;

EID: 77957804314     PISSN: 09607404     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.suronc.2009.05.004     Document Type: Review

References (73)

1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and T. Murray Cancer statistics 2008 CA Cancer J Clin 58 2008 71 96
2. F.A. Yafi, J.R. Steinberg, and W. Kassouf Contemporary management of muscle-invasive bladder cancer Int J Clin Oncol 13 2008 504 509
3. R.D. Mills, A. Fleischmann, and U.E. Studer Radical cystectomy with an extended pelvic lymphadenectomy: rationale and results Surg Oncol Clin N Am 16 2007 233 245
4. S.F. Shariat, P.I. Karakiewicz, G.S. Palapattu, Y. Lotan, C.G. Rogers, and G.E. Amiel Outcomes of radical cystectomy for transitional cell carcinoma of the bladder: a contemporary series from the Bladder Cancer Research Consortium J Urol 176 6 Pt 1 2006 2414 2422 (Pubitemid 44755069)
5. A. Stenzl, N.C. Cowan, M. De Santis, G. Jakse, M.A. Kuczyk, and A.S. Merseburger The updated EAU guidelines on muscle-invasive and metastatic bladder cancer Eur Urol 2009 Jan 13 [Epub ahead of print]
6. H. Herr, C. Lee, S. Chang, and S. Lerner Bladder Cancer Collaborative Group. Standardization of radical cystectomy and pelvic lymph node dissection for bladder cancer: a collaborative group report J Urol 171 2004 1823 1828
7. W.S. Halstead The treatment of wounds Johns Hopkins Hosp Rep 2 1891 279
8. J.A. Colston, and W.F. Leadbetter Infiltrating carcinoma of the bladder J Urol 36 1936 669 689
9. H.J. Jewitt, and G.H. Strong Infiltrating carcinoma of the bladder: relation of depth of penetration of the bladder wall to incidence of local extension and metastases J Urol 55 1946 366 372
10. W.S. Kerr, and F.H. Colby Pelvic lymph node dissection and total cystectomy in the treatment of carcinoma of the bladder J Urol 63 1950 842 851
11. W.F. Leadbetter, and J.F. Cooper Regional gland dissection for carcinoma of the bladder; a technique for one-stage cystectomy, gland dissection, and bilateral uretero-enterostomy J Urol 63 1950 242 260
12. W.F. Whitmore, and V.F. Marshall Radical total cystectomy for cancer of the bladder: 230 consecutive cases five years later J Urol 87 1962 853 868
13. J.J. Cordonnier Cystectomy in the management of carcinoma of the urinary bladder Postgrad Med J 41 1965 469 470
14. S.P. Dretler, B.D. Ragsdale, and W.F. Leadbetter The value of pelvic lymphadenectomy in the surgical treatment of bladder cancer J Urol 109 1973 414 416
15. J.A. Smith Jr., and W.F. Whitmore Jr. Regional lymph node metastasis from bladder cancer J Urol 126 1981 591 593
16. D.G. Skinner Management of invasive bladder cancer: a meticulous pelvic node dissection can make a difference J Urol 128 1982 34 36
17. J.P. Stein Lymphadenectomy in bladder cancer: how high is "high enough" Urol Oncol 24 2006 349 355
18. K.I. Wishnow, D.E. Johnson, J.Y. Ro, D.A. Swanson, R.J. Babaian, and A.C. von Eschenbach Incidence, extent and location of unsuspected pelvic lymph node metastasis in patients undergoing radical cystectomy for bladder cancer J Urol 137 1987 408 410
19. R.D. Mills, W.H. Turner, A. Fleischmann, R. Markwalder, G.N. Thalmann, and U.E. Studer Pelvic lymph node metastases from bladder cancer. Outcome in 83 patients after radical cystectomy and pelvic lymphadenectomy J Urol 166 2001 19 23
20. J. Leissner, M.A. Ghoneim, H. Abol-Enein, J.W. Thüroff, L. Franzaring, and M. Fisch Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study J Urol 171 2004 139 144
21. H. Abol-Enein, M. El-Baz, M.A. Abd El-Hameed, M. Abdel-Latif, and M.A. Ghoneim Lymph node involvement in patients with bladder cancer treated with radical cystectomy: a patho-anatomical study - a single center experience J Urol 172 5 Pt 1 2004 1818 1821
22. H. Rouviere Anatomy of the human lymphatic system 1938 Edwards Brothers Ann Arbor, Michigan p. 214
23. A. Vazina, D. Dugi, S.F. Shariat, J. Evans, R. Link, and S.P. Lerner Stage specific lymph node metastasis mapping in radical cystectomy specimens J Urol 171 2004 1830 1834
24. M.M. Knap, F. Lundbeck, and J. Overgaard The role of pelvic lymph node dissection as a predictive and prognostic factor in bladder cancer Eur J Cancer 39 5 2003 604 613
25. B.R. Konety, and S.A. Joslyn Factors influencing aggressive therapy for bladder cancer: an analysis of data from the SEER program J Urol 170 2003 1765 1771
26. B.K. Hollenbeck, Z. Ye, S.L. Wong, J.E. Montie, and J.D. Birkmeyer Hospital lymph node counts and survival after radical cystectomy Cancer 15 112 2008 806 812
27. T.M. Koppie, A.M. Serio, A.J. Vickers, K. Vora, G. Dalbagni, and S.M. Donat Age-adjusted Charlson comorbidity score is associated with treatment decisions and clinical outcomes for patients undergoing radical cystectomy for bladder cancer Cancer 112 2008 2384 2392
28. B.H. Bochner, D. Cho, H.W. Herr, M. Donat, M.W. Kattan, and G. Dalbagni Prospectively packaged lymph node dissections with radical cystectomy: evaluation of node count variability and node mapping J Urol 172 4 Pt 1 2004 1286 1290
29. I. Frank, J.C. Cheville, M.L. Blute, C.M. Lohse, A. Nehra, and A.L. Weaver Transitional cell carcinoma of the urinary bladder with regional lymph node involvement treated by cystectomy: clinicopathologic features associated with outcome Cancer 15 97 2003 2425 2431
30. K. Weingärtner, A. Ramaswamy, A. Bittinger, E.W. Gerharz, D. Vöge, and H. Riedmiller Anatomical basis for pelvic lymphadenectomy in prostate cancer: results of an autopsy study and implications for the clinic J Urol 156 1996 1969 1971
31. A.L. Poulsen, T. Horn, and K. Steven Radical cystectomy: extending the limits of pelvic lymph node dissection improves survival for patients with bladder cancer confined to the bladder wall J Urol 160 6 Pt 1 1998 2015 2019
32. M. Abdel-Latif, H. Abol-Enein, M. El-Baz, and M.A. Ghoneim Nodal involvement in bladder cancer cases treated with radical cystectomy: incidence and prognosis J Urol 172 2004 85 89
33. W. Kassouf, D. Leibovici, M.F. Munsell, C.P. Dinney, H.B. Grossman, and A.M. Kamat Evaluation of the relevance of lymph node density in a contemporary series of patients undergoing radical cystectomy J Urol 176 2006 53 57
34. I. Honma, N. Masumori, E. Sato, T. Maeda, M. Hirobe, and H. Kitamura Removal of more lymph nodes may provide better outcome, as well as more accurate pathologic findings, in patients with bladder cancer - analysis of role of pelvic lymph node dissection Urology 68 2006 543 548
35. T.M. Koppie, A.J. Vickers, K. Vora, G. Dalbagni, and B.H. Bochner Standardization of pelvic lymphadenectomy performed at radical cystectomy: can we establish a minimum number of lymph nodes that should be removed? Cancer 15 107 2006 2368 2374
36. N.B. Dhar, E.A. Klein, A.M. Reuther, G.N. Thalmann, S. Madersbacher, and U.E. Studer Outcome after radical cystectomy with limited or extended pelvic lymph node dissection J Urol 179 2008 873 878
37. W. Kassouf, P.K. Agarwal, H.W. Herr, M.F. Munsell, P.E. Spiess, and G.A. Brown Lymph node density is superior to TNM nodal status in predicting disease-specific survival after radical cystectomy for bladder cancer: analysis of pooled data from MDACC and MSKCC J Clin Oncol 26 2008 121 126
38. G.N. Thalmann, A. Fleischmann, R.D. Mills, F.C. Burkhard, M. Markwalder, and U. Studer Lymphadenectomy in bladder cancer. EAU update series 1 2003 Elsevier p. 100-7
39. F. Liedberg, and W. Mnsson Lymph node metastasis in bladder cancer Eur Urol 49 2006 13 21
40. S.P. Lerner, D.G. Skinner, G. Lieskovsky, S.D. Boyd, S.L. Groshen, and A. Ziogas The rationale for en bloc pelvic lymph node dissection for bladder cancer patients with nodal metastases: long-term results J Urol 149 1993 758 764
41. J. Leissner, R. Hohenfellner, J.W. Thüroff, and H.K. Wolf Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis BJU Int 85 2000 817 823
42. K. Steven, and A.L. Poulsen Radical cystectomy and extended pelvic lymphadenectomy: survival of patients with lymph node metastasis above the bifurcation of the common iliac vessels treated with surgery only J Urol 178 4 Pt 1 2007 1218 1223
43. J.P. Stein, D.F. Penson, J. Cai, G. Miranda, E.C. Skinner, and M.A. Dunn Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancer J Urol 177 2007 876 881
44. A.J. Bella, L.W. Stitt, J.L. Chin, and J.I. Izawa The prognostic significance of metastatic perivesical lymph nodes identified in radical cystectomy specimens for transitional cell carcinoma of the bladder J Urol 170 6 Pt 1 2003 2253 2257
45. M.A. Ghoneim, and H. Abol-Enein Lymphadenectomy with cystectomy: is it necessary and what is its extent? Eur Urol 46 4 2004 457 461
46. J.L. Wright, D.W. Lin, and M.P. Porter The association between extent of lymphadenectomy and survival among patients with lymph node metastases undergoing radical cystectomy Cancer 112 2008 2401 2408
47. B.H. Bochner, H.W. Herr, and V.E. Reuter Impact of separate versus en bloc pelvic lymph node dissection on the number of lymph nodes retrieved in cystectomy specimens J Urol 166 2001 2295 2296
48. C. Brössner, A. Pycha, A. Toth, C. Mian, and W. Kuber Does extended lymphadenectomy increase the morbidity of radical cystectomy? BJU Int 93 2004 64 66 (Pubitemid 38112968)
49. F.L. Greene, D.L. Page, I.D. Fleming, A. Fritz, C.M. Balch, and D.G. Haller AJCC cancer staging manual 6th ed. 2002 Springer-Verlag New York
50. H.W. Herr Pathologic evaluation of radical cystectomy specimens Cancer 95 2002 668 669
51. A. Fleischmann, G.N. Thalmann, R. Markwalder, and U.E. Studer Extracapsular extension of pelvic lymph node metastases from urothelial carcinoma of the bladder is an independent prognostic factor J Clin Oncol 23 2005 2358 2365 (Pubitemid 46218729)
52. R. Koren, A. Paz, M. Konichezsky, E. Sadikov, B. Klein, and P. Livne Lymph node revealing solution: a rapid method for the fixation of cystectomy specimens Pathol Res Pract 195 1999 77 80
53. P. Bassi, G.D. Ferrante, N. Piazza, R. Spinadin, R. Carando, and G. Pappagallo Prognostic factors of outcome after radical cystectomy for bladder cancer: a retrospective study of a homogeneous patient cohort J Urol 161 1999 1494 1497
54. J. Vieweg, J.E. Gschwend, H.W. Herr, and W.R. Fair Pelvic lymph node dissection can be curative in patients with node positive bladder cancer J Urol 161 1999 449 454
55. K. Gaitonde, A. Goyal, S. Nagaonkar, N. Patil, D.R. Singh, and V. Srinivas Retrospective review and long-term follow-up of radical cystectomy in a developing country BJU Int 89 Suppl. 1 2002 57 61
56. S. Madersbacher, W. Hochreiter, F. Burkhard, G.N. Thalmann, H. Danuser, and R. Markwalder Radical cystectomy for bladder cancer today - a homogeneous series without neoadjuvant therapy J Clin Oncol 21 2003 690 696
57. H. Nishiyama, T. Habuchi, J. Watanabe, S. Teramukai, H. Tada, and Y. Ono Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990-2000 in Japan Eur Urol 45 2004 176 181
58. R.E. Hautmann, J.E. Gschwend, R.C. de Petriconi, M. Kron, and B.G. Volkmer Cystectomy for transitional cell carcinoma of the bladder: results of a surgery only series in the neobladder era J Urol 176 2006 486 492
59. M.A. Ghoneim, M. Abdel-Latif, M. el-Mekresh, H. Abol-Enein, A. Mosbah, and A. Ashamallah Radical cystectomy for carcinoma of the bladder: 2,720 consecutive cases 5 years later J Urol 180 2008 121 127
60. H.W. Herr, B.H. Bochner, G. Dalbagni, S.M. Donat, V.E. Reuter, and D.F. Bajorin Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer J Urol 167 2002 1295 1298
61. J.P. Stein, J. Cai, S. Groshen, and D.G. Skinner Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: the concept of lymph node density J Urol 170 2003 35 41
62. O.N. Gofrit, K.C. Zorn, G.D. Steinberg, G.P. Zagaja, and A.L. Shalhav The Will Rogers phenomenon in urological oncology J Urol 179 1 2008 28 33
63. H.W. Herr Extent of surgery and pathology evaluation has an impact on bladder cancer outcomes after radical cystectomy Urology 61 2003 105 108
64. J. Leissner, C. Koeppen, and H.K. Wolf Prognostic significance of vascular and perineural invasion in urothelial bladder cancer treated with radical cystectomy J Urol 169 2003 955 960
65. L. Cheng, R.M. Neumann, B.G. Scherer, A.L. Weaver, B.C. Leibovich, and A. Nehra Tumor size predicts the survival of patients with pathologic stage T2 bladder carcinoma: a critical evaluation of the depth of muscle invasion Cancer 15 85 1999 2638 2647
66. M.L. Quek, J.P. Stein, P.W. Nichols, J. Cai, G. Miranda, and S. Groshen Prognostic significance of lymphovascular invasion of bladder cancer treated with radical cystectomy J Urol 174 2005 103 106
67. Y. Lotan, A. Gupta, S.F. Shariat, G.S. Palapattu, A. Vazina, and P.I. Karakiewicz Lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomy J Clin Oncol 23 2005 6533 6539
68. H.W. Herr Superiority of ratio based lymph node staging for bladder cancer J Urol 169 2003 943 945
69. H.W. Herr The concept of lymph node density - is it ready for clinical practice? J Urol 177 2007 1273 1276
70. T. Osawa, T. Abe, N. Shinohara, T. Harabayashi, A. Sazawa, and K. Kubota Role of lymph node density in predicting survival of patients with lymph node metastases after radical cystectomy: a multi-institutional study Int J Urol 16 3 2009 Mar 274 278
71. W. Kassouf, H.B. Grossman, D. Leibovici, M.F. Munsell, A. Siefker-Radtke, and L.L. Pisters Outcome of patients with bladder cancer with pN+ disease after preoperative chemotherapy and radical cystectomy Urology 73 2009 147 152
72. A. Fleischmann, G.N. Thalmann, R. Markwalder, and U.E. Studer Prognostic implications of extracapsular extension of pelvic lymph node metastases in urothelial carcinoma of the bladder Am J Surg Pathol 29 2005 89 95 (Pubitemid 40023955)
73. H.W. Herr, and S.M. Donat Outcome of patients with grossly node positive bladder cancer after pelvic lymph node dissection and radical cystectomy J Urol 165 2001 62 64