Does suppression of IL-4 synthesis by aspirin explain the therapeutic benefit of aspirin desensitization treatment?

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 4, 2010, Pages 745-746

  White, Andrew A ^a   Stevenson, Donald D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

aspirin desensitization; aspirin treatment; Aspirin exacerbated respiratory disease; IL 4 synthesis

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 1; IBUPROFEN; INTERLEUKIN 4; LEUKOTRIENE C4; LEUKOTRIENE E4; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2;

ASPIRIN EXACERBATED RESPIRATORY DISEASE; ASTHMA; COMORBIDITY; CYTOKINE PRODUCTION; DESENSITIZATION; EDITORIAL; HUMAN; INFLAMMATION; NOSE POLYP; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SINUSITIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; DESENSITIZATION, IMMUNOLOGIC; DRUG HYPERSENSITIVITY; HUMANS; INTERLEUKIN-4; RESPIRATION DISORDERS; TREATMENT OUTCOME;

EID: 77957796802     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.08.037     Document Type: Editorial

References (17)

1. M.P. Berges-Gimeno, R.A. Simon, and D.D. Stevenson Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease J Allergy Clin Immunol 111 2003 180 186
2. A. Rozsasi, D. Polzehl, T. Deutschle, E. Smith, K. Wiesmill, and H. Riechelmann Long-term treatment with aspirin desensitization: a prospective clinical trial comparing 100 and 300 mg aspirin daily Allergy 63 2008 1228 1234
3. M. Berges-Gimeno, R.A. Simon, and D.D. Stevenson The natural history and clinical characteristics of aspirin exacerbated respiratory disease Ann Allergy Asthma Immunol 89 2002 474 478
4. G. Bochenek, K. Nagraba, E. Nizankowska, and A. Szczeklik A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge J Allergy Clin Immunol 111 2003 743 749
5. P.J. Daffern, D. Muilenburg, T. Hugli, and D.D. Stevenson Association of urinary leukotriene E4 excretion during aspirin challenges with severity of respiratory responses J Allergy Clin Immunol 104 1999 559 564
6. M. Sanak, and A. Szczeklik Leukotriene C4 synthase promoter polymorphism in bronchial asthma Allergy 53 1998 112S 113S
7. P.E. Christie, B.W. Spur, and T.H. Lee The effects of lipoxin A4 on airway responses in asthmatic subjects Am Rev Respir Dis 145 1992 1281 1284
8. P. Sestini, L. Armetti, G. Gambaro, M.G. Pieroni, R.M. Refini, and A. Sala Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma Am J Respir Crit Care Med 153 1996 572 575
9. D. Schafer, M. Schmid, U.C. Gode, and H.W. Baenkler Dynamics of eicosanoids in peripheral blood cells during bronchial provocation in aspirin-intolerant asthmatics Eur Respir J 13 1999 638 646
10. R.K. Katial, M. Strand, T. Prasertsuntarasai, R. Leung, W. Zheng, and R. Alam The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases J Allergy Clin Immunol 126 2010 738 744
11. L. Borish, and L.J. Rosenwasser Cytokines in allergic inflammation N.J. Adkinson, W.W. Busse, B.S. Bochner, S.T. Holgate, R.F. Lemanske, F.E.R. Simons, Middleton: allergy principles and practice 7th ed. 2009 Elsevier Philadelphia 165 179
12. A. Cianferoni, J.T. Schroeder, J. Kim, J.W. Schmidt, L.M. Lichtenstein, and S.N. Georas Selective inhibition of interleukin-4 gene expression in human T cells by aspirin Blood 97 2001 1742 1749 (Pubitemid 32217242)
13. J.W. Steinke, J.A. Culp, E. Kropf, and L. Borish Modulation by aspirin of nuclear phosphor-signal transducer and activator of transcription 6 expression: possible role in therapeutic benefit associated with aspirin desensitization J Allergy Clin Immunol 124 2009 724 730
14. G.M. Perez, M. Melo, A.D. Keegan, and J. Zamorano Aspirin and salicylates inhibit the IL-4 and IL-13-induced activation of STAT6 J Immunol 168 2002 1428 1434
15. R. Furst, S.B. Blumenthal, A.K. Kiemer, S. Zahler, and A.M. Vollmar Nuclear factor-KB-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase-1 by the c-jun N-terminal kinase/activator protein-1 pathway J Pharmacol Exp Ther 318 2006 389 394
16. E. Nizankowska, R. Dworski, J. Soja, and A. Szczeklik Salicylate pre-treatment attenuates intensity of bronchial and nasal symptoms precipitated by aspirin in aspirin-intolerant patients Clin Exp Allergy 20 1990 647 652
17. E. Nizankowska, R. Dworski, J. Soja, and A. Szczeklik Salicylate pre-treatment attenuates intensity of bronchial and nasal symptoms precipitated by aspirin in aspirin-intolerant patients Clin Exp Allergy 20 1990 647 652