What is new in cryptorchidism and hypospadias - A critical review on the testicular dysgenesis hypothesis

Journal of Pediatric Surgery

Volumn 45, Issue 10, 2010, Pages 2074-2086

  Thorup, Jorgen ^a   McLachlan, Robert ^b   Cortes, Dina ^c,d   Nation, Tamara R ^f   Balic, Adam ^f   Southwell, Bridget R ^f   Hutson, John M ^e,f,g  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MONASH MEDICAL CENTRE   (Australia)

^c HVIDOVRE HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e ROYAL CHILDREN'S HOSPITAL   (Australia)

^f MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cryptorchidism; Epidemiology; Fertility; Hypospadias; Testicular cancer

Indexed keywords

CANCER RISK; CRYPTORCHISM; DEL CASTILLO SYNDROME; DISEASE ASSOCIATION; GENE; GENETIC ASSOCIATION; GEOGRAPHIC DISTRIBUTION; GONADAL DYSGENESIS; HUMAN; HYPOSPADIAS; INSULIN LIKE HORMONE 3 GENE; MALE INFERTILITY; MORBIDITY; NONHUMAN; ORCHIDOPEXY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SEMEN ANALYSIS; TESTIS CANCER;

CRYPTORCHIDISM; FOLLOW-UP STUDIES; GONADAL DYSGENESIS; HUMANS; HYPOSPADIAS; INFANT; INFANT, NEWBORN; MALE; MODELS, BIOLOGICAL; TESTICULAR NEOPLASMS;

EID: 77957794372     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2010.07.030     Document Type: Review

References (164)

1. Asklund C., Jorgensen N., and Jensen T.K. Biology and epidemiology of testicular dysgenesis syndrome BJU Int 93 Suppl 3 2004 6 11
2. Skakkebaek N.E., Rajpert De- Meyts E., and Main K.M. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects Hum Reprod 16 2001 972 978
3. Sharpe R.M., and Skakkebaek N.E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341 1993 1392 1393
4. Toppari J., Larsen J.C., and Christiansen P. Male reproductive health and environmental xenoestrogens Environ Health Perspect 104 1996 741 803
5. Sharpe R.M. The 'oestrogen hypothesis'-where do we stand now? Int J Androl 26 2003 2 15
6. Fisher J.S., Macpherson S., and Marchetti N. Human 'testicular dysgenesis syndrome': a possible model using in utero exposure of the rat to dibutyl phthalate Hum Reprod 18 2003 1383 1394
7. J Main K.M., Kiviranta H., and Virtanen H.E. Toppari. Flame retardants in placenta and breast milk and cryptorchidism in newborn boys Environ Health Perspect 115 2007 1519 1526
8. Kelce W.R., and Wilson E.M. Environmental antiandrogens: developmental effects, molecular mechanisms, and clinical implications J Mol Med 75 1997 198 207
9. Viguier-Martinez M.C., Hochereau de Reviers M.T., and Barenton B. Effect of a non-steroidal antiandrogen, Flutamide, on the hypothalamo-pituitary axis, genital tract and testis in growing male rats: endocrinological and histological data Acta Endocrinol 102 1983 299 306
10. Newbold R.R., Bullock B.C., and McLachlan J.A. Lesions of the rete testis in mice exposed prenatally to diethylstilbestrol Cancer Res 45 1985 5145 5150
11. Yasuda Y., Kihara T., and Tanimura T. Effect of ethinyl estradiol on the differentiation of mouse fetal testis Teratology 32 1985 113 118
12. Walker A.H., Bernstein L., and Warren D.W. The effect of in utero ethinyl oestradiol exposure on the risk of cryptorchid testis and testicular teratoma in mice Br J Cancer 62 1990 599 602
13. Shono T., Kai H., and Suita S. Time-specific effects of mono-n-butyl phthalate on the transabdominal descent of the testis in rat fetuses BJU Int 86 2000 121 125
14. Ming-Hsien W., and Bsaskin L.S. Endocrine disruptors, genital review development, and hypospadias J Androl 29 2008 499 505
15. Fredell L., Kockum I., and Hansson E. Heredity of hypospadias and the significance of low birth weight J Urol 167 2002 1423 1427
16. Calzolari E., Contiero M.R., and Roncarati E. Aetiological factors in hypospadias J Med Genet 23 1986 333 336
17. Chen Y.C., and Woolley P.V. Genetic studies on hypospadias in males J Med Genet 8 1971 153 156
18. Akre O., Lipworth L., and Cnattingius S. Risk factor patterns for cryptorchidism and hypospadias Epidemiology 10 1999 364 369
19. Weidner I.S., Moller H., and Jensen T.K. Risk factors for cryptorchidism and hypospadias J Urol 161 1999 1606 1609
20. Fredell L., Lichtenstein P., and Pedersen N.L. Hypospadias is related to birth weight in discordant monozygotic twins J Urol 160 1998 2197 2201
21. Smith G.C., Smith M.F., and McNay M.B. First-trimester growth and the risk of low birth weight N Engl J Med 339 1998 1817 1820
22. Breddam M.K., Cortes D., and Thorup J. Incidence rates of hypospadias in Denmark Pediatric Nephrology 23 2008 1671
23. Stoll C., Alembik Y., and Roth M.P. Genetic and environmental factors in hypospadias J Med Genet 27 1990 559 562
24. Källen B. Case control study of hypospadias, based on registry information Teratology 38 1988 45 49
25. Fisch H., Golden R.J., and Libersen G.L. Maternal age as a risk factor for hypospadias J Urol 165 2001 934 939
26. Bauer S.B., Retik A.B., and Colodny A.H. Genetic aspects of hypospadias Urol Clin North Am 8 1981 559 562
27. Bauer S.B., Bull M.J., and Retik A.B. Hypospadias: a familial study J Urol 121 1979 474 479
28. Czeizel A., Toth J., and Erodi E. Aetiological studies of hypospadias in Hungary Hum Hered 29 1979 166 170
29. Monteleone Neto R., Castilla E.E., and Paz J.E. Hypospadias: an epidemiological study in Latin America Am J Med Genet 10 1981 5 10
30. Sweet R.A., Schrott H.G., and Kurland R. Study of the incidence of hypospadias in Rochester, Minnesota, 1940-1970, and a case-control comparison of possible etiological factors Mayo Clin Proc 49 1974 52 56
31. Paulozzi L.J. International trends in rates of hypospadias and cryptorchidism Environ Health Perspect 107 1999 297 302
32. Sorensen H.R. Hypospadias, with special reference to aetiology. Thesis, University of Copenhagen. Munksgaard, Copenhagen 1953
33. Boisen K.A., Chellakooty M., and Schmidt I.M. Hypospadias in a cohort of 1072 Danish newborn boys; prevalence and relationship to placental weight, anthropometrical measurements at birth and reproductive hormone levels at three months of age J Clin Endocrinol Metab 90 2005 4041 4046
34. Fisch H., Lambert S.M., and Hensle T.W. Hypospadias rates in New York State are not increasing J Urol 181 2009 2291 2294
35. Fisch H., Hyun G., and Hensle T.W. Rising hypospadias rates: disproving a myth J Ped Urol 6 2010 37 39
36. Aschim E.L., Haugen T.B., and Tretli S. Risk factors for hypospadias in Norwegian boys-association with testicular dysgenesis syndrome? Int J Androl 27 2004 213 221
37. Asklund C., Jensen T.K., and Main K.M. Semen quality, reproductive hormones and fertility of men operated for hypospadias Int J Androl 33 2010 80 87
38. Bracka A. A long term view of hypospadias Br J Plastic Surg 42 1989 251 255
39. Cortes D. Cryptorchidism-aspects of pathogenesis, histology and treatment Scand J Urol Nephrol Suppl 196 1998 1 54
40. Jorgensen N., Meyts E.R., and Main K.M. Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis Int J Androl 33 2010 298 303
41. Hutson J.M., and Hasthorpe S. Testicular descent and cryptorchidism: the state of the art in 2004 J Pediatr Surg 40 2005 297 302
42. Hadziselimovic F., and Herzog B. Hodendystopie J.W. Thüroff, H. Schulte-Wissermann, Kinderurologie in Klinik und Praxis 2nd ed. 2000 Thieme Stuttgart 484 500
43. Virtanen H.E., Cortes D., and Rajpert-De Meyts E. Development and descent of the testis in relation to cryptorchidism Acta Paediatr 96 2007 622 627
44. Hutson J.M., Hasthorpe S., and Heyns C.F. Anatomical and functional aspects of testicular descent and cryptorchidism Endocr Rev 18 1997 259 280
45. Hutson J.M. Testicular feminization: a model for testicular descent in mice and men J Pediatr Surg 21 1986 195 198
46. Adham I.M., and Agoulnik A.I. Insulin-like 3 signalling in testicular descent Int J Androl 27 2004 257 265
47. Agoulnik A.I. Relaxin and related peptides in male reproduction Adv Exp Med Biol 612 2007 49 64
48. Trem blay J.J., and Robert N.M. Role of nuclear receptors in INSL3 gene transcription in Leydig cells Ann N Y Acad Sci 1061 2005 183 189
49. Nef S., and Parada L.F. Cryptorchidism in mice mutant for Insl3 Nat Genet 22 1999 295 299
50. Yamazawa K., Wada Y., and Sasagawa I. Mutation and polymorphism analyses of INSL3 and LGR8/GREAT in 62 Japanese patients with cryptorchidism Horm Res 67 2007 73 76
51. Ferlin A., Bogatcheva N.V., and Gianeselto L. Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization Mol Hum Reprod 12 2006 401 406
52. Roh J., Virtanen H., and Kumagai J. Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism Reprod Biomed Online 7 2003 400 406
53. Thorup J., Kvist N., and Larsen P. Clinical results of early and late correction of undescended testes Br J Urol 56 1984 322 325
54. Baker L.A., Docimo S.G., and Surer I. A multi-institutional analysis of laparoscopic orchiopexy BJU Int 87 2001 484 489
55. Hay S.A., Soliman H.A., and Rahman A.H.A. Laparoscopic classification and treatment of the impalpable testis Ped Surg Int 15 1999 570 572
56. El Gohary M.A. Non-descent of the testis: an overlooked laparoscopic finding J Ped Urol 4 2008 364 366
57. Samadi A.A., Palmer L.S., and Franco I. Laparoscopic orchiopexy: report of 203 cases with review of diagnosis, operative technique, and lessons learned Journal of Endourology 17 6 2003 365 368
58. Cortes D., and Thorup J. Pathoanatomic and histopathological findings in intra-abdominal testes Personal communication. 3rd workshop-Paediatric Andrology, Liestal 2009
59. Damgaard I.N., Jensen T.K., and Petersen J.H. Risk factors for congenital cryptorchidism in a prospective birth cohort study PLoS One 3 2008 3051
60. Cortes D., Thorup J., and Frisch M. Examination for intratubular germ cell neoplasia at operation for undescended testis in boys J Urol 151 1994 722 725
61. Harnaen E.J., Na A.F., and Shenker N.S. The anatomy of the cremaster muscle during inguinoscrotal testicular descent in the rat J Pediatr Surg 42 2007 1982 1987
62. Husmann D.A., and Levy J.B. Current concepts in the pathophysiology of testicular undescend Urology 46 1995 267 276
63. Huynh J., Shenker N.S., and Nightingale S. Signalling molecules: clues from development of the limb bud for cryptorchidism? Pediatr Surg Int 23 2007 617 624
64. Cohn M.J., and Tickle C. Limbs: a model for pattern formation within the vertebrate body plan Trends Genet 12 1996 253 257
65. Wang Y., Barthold J., and Kanetsky P.A. Allelic variants in HOX genes in cryptorchidfsm Birth Defects Res Clin Mol Teratol 79 2007 269 275
66. Rijli F.M., Matyas R., and Pellegrini M. Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice Proc Natl Acad Sci U S A 92 1995 8185 8189
67. Hsieh-Li H.M., Witte D.P., and Weinstein M. Hoxa11 structure, extensive antisense transcription, and function in male and female fertility Development 121 1995 1373 1385
68. Nation T.R., Balic A., and Southwell B.R. The hormonal control of testicular descent Ped Endocrinol Rev 7 2009 22 31
69. Heyns C.F. The gubernaculum during testicular descent in the human fetus J Anat 153 1987 93 112
70. Kaplan S.L., Grumbach M.M., and Aubert M.L. The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function Recent Prog Horm Res 32 1976 161 243
71. Gendrel D., Roger M., and Chaussain J.L. Correlation of pituitary and testicular responses to stimulation tests in cryptorchid children Acta Endosc 86 1977 641 650
72. McGlynn K.A., Graubard B.I., and Nam J.M. Maternal hormone levels and risk of cryptorchism among populations at high and low risk of testicular germ cell tumors Cancer Epidemiol Biomarkers Prev 14 2005 1732 1737
73. Sherma L.S., Potter S.S., and Scott W.J. W.J. Larsen, Human embryology 3rd ed. 2001 Churchill Livingstone Philadelphia 1 548
74. Cortes D., Thorup J., and Beck B.L. Cryptorchidism as a caudal developmental field defect APMIS 106 1998 953 958
75. Cortes D., Thorup J., and Beck B.L. Quantitative histology of germ cells in the undescended testes of human fetuses, neonates and infants J Urol 154 1995 1188 1192
76. Campbell M.F. Anomalies of the testicle M.F. Campbell, Urology 1963 WB Saunders Philadelphia 1769 1791
77. Cortes D., Thorup J., and Nielsen O.H. Cryptorchidism in boys with imperforate anus J Ped Surg 30 1995 631 635
78. Stevenson R.E., Jones K.L., and Phelan M.C. The pathogenetic mechanism producing sirenomelia and associated defects of the viscera and soft tissues Pediatrics 78 1986 451 457
79. Jensen M.S., Toft G., and Thulstrup A.M. Cryptorchidism concordance in monozygotic and dizygotic twin brothers, full brothers, and half-brothers Fertil Steril 93 2010 124 129
80. Boisen K.A., Kaleva M., and Main K.M. Differences in prevalence of congenital cryptorchidism in infants between two Nordic countries Lancet 363 2004 1264 1269
81. Thonneau P.F., Candia P., and Mieusset R. Cryptorchidism: incidence, risk factors, and potential role of environment. An update J Androl 24 2003 155
82. Toppari J., Kaleva M., and Virtanen H.E. Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data Hum Reprod Update 7 2001 282
83. Barthold J.S., and Gonzalez R. The epidemiology of congenital cryptorchidism, testicular ascent and orchiopexy J Urol 170 2003 2396 2401
84. Meyers N.A. Undescended testis: congenital or acquired Aust Paediatr J 11 1975 76 79
85. Villumsen A.L., and Zachau-Christiansen B. Spontaneous alterations in position of the testes Arch Dis Child 41 1966 198 200
86. John Radciffe Hospital Cryptorchidism Study Group Cryptorchidism: a prospective study of 7500 consecutive male births, 1984-8 Arch Dis Child 67 1992 892
87. Berkowitz G.S., Lapinski R.H., and Dolgin S.E. Prevalence and natural history of cryptorchidism Pediatrics 92 1993 44 49
88. Buemann B., Henriksen H., and Villumsen A.L. Incidence of undescended testis in the newborn Acta Chir Scan Suppl 283 1961 289 293
89. Thorup J., Cortes D., and Petersen B.L. The incidence of bilateral cryptorchidism is increased and the fertility potential is reduced in sons born to mothers who have smoked during pregnancy J Urol 176 2006 734 737
90. Biggs L.M., Baer A., and Critchlow C.W. Maternal, delivery, and perinatal characteristics associated with cryptorchidism: a population-based case-control study among birth in Washington state Epidemiol 13 2002 197 204
91. Cortes D., Kjellberg E.M., and Breddam M. The true incidence of cryptorchidism in Denmark J Urol 179 2008 314 318
92. Scorer C.G. The descent of the testis Arch Dis Child 39 1964 605
93. Hirasing R.A., Grimberg R., and Hirasing H.D. Incidence of undescended testes in young children Nedrlands Tijdschrift voor Geneeskunde 126 1982 2294 2296
94. Thong M.K., Lim C.T., and Fatimah H. Undescended testes: incidence in 1002 consecutive male infants and outcome at 1 year of age Pediatr Surg In 13 1998 37 41
95. Ghirri P., Ciulli C., and Vuerich M. Incidence at birth and natural history of cryptorchidism: a study of 10730 consecutive male infants J Endocrnol Invest 25 2002 709 715
96. Preiksa R.T., Zilaitiene B., and Matulivesius V. Higher than expected prevalence of congenital cryptorchidism in Lithuania: a study of 1204 boys at birth and 1-year follow up Hum Reprod 20 2005 1928 1932
97. Thorup J., and Cortes D. Surgical treatment and follow up on undescended testes Pediatr Endocrinol Rev 7 2009 38 43
98. Algarwal P.K., Diaz M., and Elder J.S. Retractile testis-is it really a normal variant J Urol 175 2006 1496 1499
99. Thorup J., and Cortes D. The incidence of maldescended testes in Denmark Pediatr Surg Int 5 1990 2 5
100. Ward B., and Hunter W.M. The absent testicle. A report on a survey carried out among schoolboys in Nottingham Br Med J 9 1960 1110 1111
101. Blom K. Undescended testis and the time of spontaneous descent in 2516 Schoolboys Ugeskr Laeger 146 1984 616 617
102. Han S.W., Lee T., and Kim J.H. Pathological differences between retractile and cryptorchid testes J URol 162 1999 878 891
103. Rusnack S.L., Wu S.Y., and Huff D.S. The ascending testis and the testis undescended since birth share the same histopathology J Urol 168 2002 2590 2594
104. Bremholm Rasmussen T., Ingerslev H.J., and Hostrup H. Bilateral spontaneous descent after the age of 10: subsequent effects on fertility Br J Surg 75 1988 820 823
105. Rabinowitz R., and Hulbert W.C. Late presentation of cryptorchidism: the etiology of testicular re-ascent J Urol 157 1997 1892 1894
106. Mayr j., Rune G.M., and Holas A. Ascent of the testis in children Eur J Pediatr 154 1995 893 895
107. Dahl H.M., Nerhus T.K., and Haga O.S. Ascent of the testis Tidsskr Nor Laegeforen 115 1995 598 600
108. Hack W.W., Meijer R.W., and Van Der L.M. Previous testicular position in boys referred for an undescended testis: further explanation of the late orchidopexy enigma? BJU Int 92 2003 293 296
109. Hutson J.M., and Hasthorpe S. Abnormalities of testicular descent Cell Tissue Res 322 2005 155 158
110. Clarnette T.D., Rowe D., and Hasthorpe S. Incomplete disappearance of the processus vaginalis as a cause of ascending testis J Urol 157 1997 1889 1891
111. Chilvers C., Oike M.C., and Forman D. Apparent doubling of frequency of undescended testes in England and Wales in 1962-81 Lancet 2 1984 330 333
112. Campbell D.M., Webb J.A., and Hargreave T.B. Cryptorchidism in Scotland Br Med J 295 1987 1235 1239
113. Tamhne R.C., Jarvis S.N., and Waterston A.J. Auditing community screening for undescended testes Arch Dis Child 65 1990 888 891
114. Jones M.E., Swerdlow A.J., and Griffith M. Prenatal risk factors for cryptorchidism: a record linkage study Paediatr Perinat Epidemiol 12 1998 383 386
115. Fenton E.J.M., Woodward A.A., and Hudson I.L. The ascending testis Ped Surg Int 5 1990 6 9
116. Toledano M.B., Hansell A.L., and Jarup L. Temporal trends in orchidopexy, great Britain, 1992-1998 Environ Health Perspect 111 2003 129 132
117. Capello S.A., Giorgi L.J., and Kogan B.A. Orchiopexy practice patterns in New York State from 1984 to 2002 J Urol 176 2006 1180 1183
118. Bonney T., Southwell B., and Donnath S. Orchidopexy trends in the paediatric population of Victoria, 1999-2006 J Ped Surg 44 2009 427 431
119. Hadziselimovic F., and Hoecht B. Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism Klin Pädiatr 220 2008 302 307
120. Hadziselimovic F., and Herzog B. The importance of both an early orchidopexy and germ cell maturation for fertility Lancet 358 2001 1156 1157 (Pubitemid 32971852)
121. Cortes D., Petersen B.L., and Thorup J. Testicular histology in cryptorchid boys-aspects of fertility J Pediatr Surg Specialities 1 2007 34 38
122. Hadziselimovic F., Hecker E., and Herzog B. The value of testicular biopsy in cryptorchidism Urol Res. 12 3 1984 171 174
123. Cortes D., Thorup J., and Visfeldt J. Cryptorchidism: aspects of fertility and neoplasms Horm Res 55 2001 21
124. Taran I., and Elder J.S. Results of orchiopexy for the undescended testis World J Urol 24 2006 231 239
125. Thorup J., Cortes D., and Petersen B.L. Histopathology of the intra-abdominal testis J Ped Urol 3 Suppl. 1 2007 39 40
126. Lee P.A., and Coughlin M.T. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone and semen data Horm Res 55 2001 28 32
127. Taskinen S., Hovatta O., and Wikstrom S. Early treatment of cryptorchidism, semen quality and testicular endocrinology J Urol 156 1996 82 84
128. Engeler D.S., Hosli P.O., and John H. Early orchiopexy: prepubertal intratubular germ cell neoplasia and fertility outcome Urology 56 2000 144 148
129. Lee P.A., O'Leary L.A., and Songer N.J. Paternity after unilateral cryptorchidism: a controlled study Pediatrics 98 1996 676 679
130. Hadziselimovic F., Hadziselimovic N.O., and Demougin P. EGR4 is a master gene responsible for fertility in cryptorchidism Sex Dev 3 2009 253 263
131. Carlsen E., Giwercman A., and Keiding N. Declining semen quality and increasing incidence of testicular cancer: is there a common cause? Environ Health Perspect 103 1995 137 139
132. Swan S.H., Elkin E.P., and Fenster L. Have sperm densities declined? A reanalysis of global trend data Environ Health Perspect 105 1997 1228 1232
133. Auger J., Kunstmann J.M., and Czyglik F. Decline in semen quality among fertile men in Paris during the past 20 years N Engl J Med 332 1995 281 285
134. Irvine S., Cawood E., and Richardson D. Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years Br Med J 312 1996 467 471
135. Fisch H., Goluboff E.T., and Olson J.H. Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality Fertil Steril 65 1996 1009 1014
136. Handelsman D.J. Sperm output of healthy men in Australia: magnitude of bias due to self-selected volunteers Hum Reprod 12 1997 2701 2705
137. Vierula M., Niemi M., and Keiski A. High and unchanged sperm counts of Finnish men Int J Androl 19 1996 11 17
138. Fisch H. Declining worldwide sperm counts: disproving a myth Urol Clin North Am 35 2008 137 139
139. Saidi J.A., Chang D.T., and Goluboff E.T. Declining sperm counts in the United States? A critical review J Urol 161 1999 460 464
140. Storgaard L. L. Storgaard, Genetical and prenatal determinants for semen quality: an epidemiological twin study 2003 Faculty of Health Sciences, University of Aarhus, Aarhus; Epidemiology and Social Medicine press 1 71
141. Storgaard L., Bonde J.P., and Ernst E. Does smoking during pregnancy affect sons sperm counts? Epidemiology 14 2003 278 286 [With comment in: Epidemiology 2003 May; 14: 261-2]
142. Jensen T.K., Jorgensen N., and Punab M. Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood: a cross-sectional study of 1770 young men from general population in five European countries Am J Epidemiol 159 2004 49 58
143. Collodel G., Capitani S., and Pammolli A. Semen quality of male idiopathic infertile smokers and non-smokers: an ultrastructural study J Androl 31 2010 108 113
144. Kort H.I., Massey J.B., and Elsner C.W. Impact of body mass index values on sperm quantity and quality J Androl 27 2006 450 452
145. Andersen H.R., Schmidt I.M., and Grandjean P. Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy Environ Health Perspect 116 2008 566 572
146. Moller H., and Skakkebaek N.E. Risk of testicular cancer in subfertile men: case-control study BMJ 318 1999 559 562
147. Moller H. Epidemiological studies of testicular germ cell cancer 2001 Thames Cancer Registry, Kings College London
148. Manecksha R.P., and Fitzpatrick J.M. Epidemiology of testicular cancer BJUI 104 2009 1329 1333
149. Petersen P.M., Giwercman A., and Hansen S.W. Impaired testicular function in patients with carcinoma-in-situ of the testis J Clin Oncol 17 1999 173 179
150. Pettersson A., Richiardi L., and Nordenskjold A. Age at surgery for undescended testis and risk of testicular cancer N Eng J Med 356 2007 1835 1841
151. Walsh T.J., Dall'Era M.A., and Croughan M.S. Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer J Urol 178 2007 1440 1446
152. Swerdlow A.J., Higgins C.D., and Pike M.C. Risk of testicular cancer in cohort of boys with cryptorchidism BMJ 314 1997 1507 1509
153. Parkin D.M., Whelan S.L., and Ferlay J. Cancer incidence in five continents, Vol I to VIII. IARC Cancer Base No. 7 2005 ICancer Mondial Web site Lyon 1 1286
154. M.P. Curado, B. Edwards, H.R. Shin, Cancer incidence in five continents, Vol. IX. IARC Scientific Publications no. 160 2007 IARC Cancer Mondial Web site Lyon 1 897
155. Huyghe E., Matsuda T., and Thonneau P. Increasing incidence of testicular cancer worldwide: a review J Urol 170 2003 5 11
156. Purdue M.P., Devesa S.S., and Sigurdson A.J. International patterns and trends in testis cancer incidence Int J Cancer 115 2005 822 827
157. Schwartz G.G. Hypothesis: does ochratoxin A cause testicular cancer? Cancer Causes Control 13 2002 91 100
158. Westergaard T., Olsen J.H., and Frisch M. Cancer risk in fathers and brothers of testicular cancer patients in Denmark. A population-based study Int J Cancer 66 1996 627 631
159. Sonneveld D.J.A., Sleijfer D.T.h., and Schraffordt Koops H. Familial testicular cancer in a single-centre population Eur J Cancer 35 1999 1368 1373
160. Hemminki K., and Chen B. Familial risks in testicular cancer as aetiological clues Int J Androl 29 2006 205 210
161. Ekbom A., Richiardi L., and Akre O. Age at immigration and duration of stay in relation to risk for testicular cancer among Finnish immigrants in Sweden J Nat Cancer Inst 95 2003 1238 1240
162. Hemminki K., and Li X. Cancer risks in Nordic immigrants and their offspring in Sweden Eur J Cancer 38 2002 2428 2434 (Pubitemid 35387496)
163. Rapley E.A., Crockford G.P., and Teare D. Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours Nat Genet 24 2000 197 200
164. Rapley E.A., Crockford G.P., and Easton D.F. International testicular cancer linkage consortium. Localisation of susceptibility genes for familial testicular germ cell tumour APMIS 111 2003 128 133