Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

Journal of Ethnopharmacology

Volumn 132, Issue 1, 2010, Pages 200-205

  Esmaeili Mahani, Saeed ^a   Rezaeezadeh Roukerd, Maryam ^a   Esmaeilpour, Khadije ^a   Abbasnejad, Mehdi ^a   Rasoulian, Bahram ^b   Sheibani, Vahid ^c   Kaeidi, Ayat ^a,b   Hajializadeh, Zahra ^c  

^a SHAHID BAHONAR UNIVERSITY OF KERMAN   (Iran)

^b LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antinociception; Formalin test; Hot plate; Olive leaf extract; Rats; Tail flick

Indexed keywords

ANTINOCICEPTIVE AGENT; MORPHINE; OLEA EUROPAEA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG ISOLATION; DRUG POTENTIATION; HOT PLATE TEST; HYPERALGESIA; LOW DRUG DOSE; MALE; NONHUMAN; OLIVE TREE; OPEN FIELD BEHAVIOR; PAIN; PAIN THRESHOLD; PLANT LEAF; RAT; TAIL FLICK TEST;

ANALGESIA; ANALGESICS; ANIMALS; HYPERALGESIA; MALE; MORPHINE; OLEA; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR;

OLEA EUROPAEA; RATTUS; RATTUS NORVEGICUS;

EID: 77957789946     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.08.013     Document Type: Article

References (30)

1. Beaudry F., Ross A., Lema P.P., Vachon P. Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain. Phytotherapy Research 2010, 24:525-530.
2. Briante R., Patumi M., Terenziani S., Bismuto E., Febbraio F., Nucci R. Olea europaea L. leaf extract and derivatives: antioxidant properties. Journal of Agricultural and Food Chemistry 2002, 50:4934-4940.
3. Bianco A., Uccella N. Biophenolic components of olives. Food Research International 2000, 33:475-485.
4. Cherif S., Rahal N., Haouala M., Hizaoui B., Dargouth F., Gueddiche M., et al. A clinical trial of a titrated Olea extract in the treatment of essential arterial hypertension. Journal de Pharmacie de Belgique 1996, 51:69-71.
5. D'Amour F.E., Smith D.L. A method of determining loss of pain sensation. Journal Pharmacology and Experimental Therapeutic 1941, 27:74-79.
6. de Campos Buzzi F., Franzoi C.L., Antonini G., Fracasso M., Filho V.C., Yunes R.A., et al. Antinociceptive properties of caffeic acid derivatives in mice. European Journal of Medicinal Chemistry 2009, 44:4596-4602.
7. Del Pozo E., Rouiz Garcia C., Bayens J.M. Analgesic effect of diltiazem and verapamil after central and peripheral administration in the hot-plate test. General Pharmacology 1990, 21:681-685.
8. Dolatshahi-Somehsofla M., Esmaeili-Mahani S., Motamedi F., Haeri A., Ahmadiani A. Adrenalectomy potentiates the antinociceptive effects of calcium channel blockers. Pharmacology Biochemistry and Behavior 2009, 92:327-334.
9. Dubuisson D., Dennis S.G. The formalin test: a quantitative study of the analgesic effect of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977, 4:161-174.
10. El Beyrouthy M., Arnold N., Delelis-Dusollier A., Dupont F. Plants used as remedies antirheumatic and antineuralgic in the traditional medicine of Lebanon. Journal of Ethnopharmacology 2008, 120:315-334.
11. Esmaeili-Mahani S., Vahedi S., Motamedi F., Pourshanazari A., Khaksari M., Ahmadiani A. Nifedipine potentiates antinociceptive effects of morphine in rats by decreasing hypothalamic pituitary adrenal axis activity. Pharmacology Biochemistry and Behavior 2005, 82:17-23.
12. Esmaeili-Mahani S., Motamedi F., Ahmadiani A. Involvement of hypothalamic pituitary adrenal axis on the nifedipine-induced antinociception and tolerance in rats. Pharmacology Biochemistry and Behavior 2006, 85:422-427.
13. Esmaeili-Mahani S., Fereidoni F., Javan M., Maghsoudi N., Motamedi F., Ahmadiani A. Nifedipine suppresses morphine-induced thermal hyperalgesia: evidence for the role of corticosterone. European Journal of Pharmacology 2007, 567:95-101.
14. +2 channels in rats. Journal of Neuroscience Research. 2008, 86:471-479.
15. 2+-channel blockers potentiate morphine analgesia in mice. Life Sciences 2003, 73:2873-2881.
16. Galeotti N., Bartolini A., Ghelardini C. Role of intracellular calcium in acute thermal pain perception. Neuropharmacology 2004, 47:935-944.
17. Gilani A.H., Khan A., Shah A.J., Connor J., Jabeen Q. Blood pressure lowering effect of olive is mediated through calcium channel blockade. International Journal of Food Sciences and Nutrition 2005, 56:613-620.
18. Gong D., Geng C., Jiang L., Cao J., Yoshimura H., Zhong L. Effects of Hydroxytyrosol-20 on carrageenan-induced acute inflammation and hyperalgesia in rats. Phytotherapy Research 2009, 23:646-650.
19. Hashemi P., Delfan B., Ghiasvand A.R., Alborzi M., Raeisi F. A study of the effects of cultivation variety, collection time and climate on the level of oleuropein in olive leaves. Acta Chromatographica 2010, 22:131-138.
20. Maione S., Starowicz K., Cristino L., Guida F., Palazzo E., Luongo L., Rossi F., Marabese I., de Novellis V., Di Marzo V. Functional interaction between TRPV1 and micro-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia. Journal of Neurophysiology 2009, 101:2411-2422.
21. Miranda H.F., Pelissier T., Sierralta F. Analgesic effect of intracerebroventricular administration of calcium channel blockers in mice. General Pharmacology 1993, 24:201-204.
22. Mohagheghi F., Bigdeli M.R., Rasoulian B., Hashemi P., Rashidi Pour M. The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine 2010, 10.1016/j.phymed.2010.06.007.
23. Nagy I., Santha P., Jancso G., Urban L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. European Journal of Pharmacology 2004, 500:351-369.
24. Pathak D., Pathak K., Singla A.K. Flavonoids as medicinal agents. Recent advances. Fitoterapia 1991, 62:371-389.
25. Ryan D., Antolovich M., Prenzler P., Robards K., Lavee S. Biotransformations of phenolic compounds in Olea europaea L. Scientia Horticulturae 2002, 92:147-176.
26. 2+ channel antagonistic effects. Journal of Ethnopharmacology 2008, 120:233-240.
27. Weiss N., De Waard M. Voltage-dependent calcium channels at the heart of pain perception. Medical Sciences (Paris) 2006, 22:396-404.
28. Wu S.L., Chen J.C., Li C.C., Lo H.Y., Ho T.Y., Hsiang C.Y. Vanillin improves and prevents trinitrobenzene sulfonic acid-induced colitis in mice. Journal of Pharmacology and Experimental Therapeutics 2009, 330:370-376.
29. Yaksh T.L., Rudy T.A. Analgesia mediated by a direct spinal action of narcotics. Science 1976, 192:1357-1358.
30. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.