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Volumn 5, Issue 8, 2010, Pages

The effect of leflunomide on cycling and activation of t-cells in HIV-1-infected participants

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; COLESTYRAMINE; HLA DR ANTIGEN; KI 67 ANTIGEN; LEFLUNOMIDE; PLACEBO; IMMUNOLOGIC FACTOR; ISOXAZOLE DERIVATIVE; VIRUS RNA;

EID: 77957777997     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011937     Document Type: Article
Times cited : (41)

References (36)
  • 1
    • 0032146161 scopus 로고    scopus 로고
    • CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency
    • Liu Z, Cumberland WG, Hultin LE, Kaplan AH, Detels R, et al. (1998) CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiency. J Acquir Immune Defic Syndr Hum Retrovirol 18: 332-340.
    • (1998) J Acquir Immune Defic Syndr Hum Retrovirol , vol.18 , pp. 332-340
    • Liu, Z.1    Cumberland, W.G.2    Hultin, L.E.3    Kaplan, A.H.4    Detels, R.5
  • 2
    • 0030668834 scopus 로고    scopus 로고
    • Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression
    • Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, et al. (1997) Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 16: 83-92.
    • (1997) J Acquir Immune Defic Syndr Hum Retrovirol , vol.16 , pp. 83-92
    • Liu, Z.1    Cumberland, W.G.2    Hultin, L.E.3    Prince, H.E.4    Detels, R.5
  • 3
    • 0041327667 scopus 로고    scopus 로고
    • Persistent immune activation in HIV-1 infection is associated with progression to AIDS
    • Hazenberg MD, Otto SA, van Benthem BH, Roos MT, Coutinho RA, et al. (2003) Persistent immune activation in HIV-1 infection is associated with progression to AIDS. Aids 17: 1881-1888.
    • (2003) Aids , vol.17 , pp. 1881-1888
    • Hazenberg, M.D.1    Otto, S.A.2    van Benthem, B.H.3    Roos, M.T.4    Coutinho, R.A.5
  • 4
    • 0038417311 scopus 로고    scopus 로고
    • Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover
    • Anthony KB, Yoder C, Metcalf JA, DerSimonian R, Orenstein JM, et al. (2003) Incomplete CD4 T cell recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell activation and turnover. J Acquir Immune Defic Syndr 33: 125-133.
    • (2003) J Acquir Immune Defic Syndr , vol.33 , pp. 125-133
    • Anthony, K.B.1    Yoder, C.2    Metcalf, J.A.3    Dersimonian, R.4    Orenstein, J.M.5
  • 5
    • 0037343278 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
    • Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP, et al. (2003) Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 18: 441-452.
    • (2003) Immunity , vol.18 , pp. 441-452
    • Silvestri, G.1    Sodora, D.L.2    Koup, R.A.3    Paiardini, M.4    O'Neil, S.P.5
  • 6
    • 34147190899 scopus 로고    scopus 로고
    • Role of immune activation in HIV pathogenesis
    • Hunt PW (2007) Role of immune activation in HIV pathogenesis. Curr HIV/AIDS Rep 4: 42-47.
    • (2007) Curr HIV/AIDS Rep , vol.4 , pp. 42-47
    • Hunt, P.W.1
  • 7
    • 27644513772 scopus 로고    scopus 로고
    • Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions
    • Beignon AS, McKenna K, Skoberne M, Manches O, DaSilva I, et al. (2005) Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest 115: 3265-3275.
    • (2005) J Clin Invest , vol.115 , pp. 3265-3275
    • Beignon, A.S.1    McKenna, K.2    Skoberne, M.3    Manches, O.4    Dasilva, I.5
  • 8
    • 34247602007 scopus 로고    scopus 로고
    • Human immunodeficiency virus-like particles activate multiple types of immune cells
    • Sailaja G, Skountzou I, Quan FS, Compans RW, Kang SM (2007) Human immunodeficiency virus-like particles activate multiple types of immune cells. Virology 362: 331-341.
    • (2007) Virology , vol.362 , pp. 331-341
    • Sailaja, G.1    Skountzou, I.2    Quan, F.S.3    Compans, R.W.4    Kang, S.M.5
  • 9
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, et al. (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12: 1365-1371.
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3    Asher, T.E.4    Silvestri, G.5
  • 10
    • 0029882175 scopus 로고    scopus 로고
    • Programmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression
    • Gougeon ML, Lecoeur H, Dulioust A, Enouf MG, Crouvoiser M, et al. (1996) Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J Immunol 156: 3509-3520.
    • (1996) J Immunol , vol.156 , pp. 3509-3520
    • Gougeon, M.L.1    Lecoeur, H.2    Dulioust, A.3    Enouf, M.G.4    Crouvoiser, M.5
  • 11
    • 25444490409 scopus 로고    scopus 로고
    • Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: Role of type I IFN-producing plasmacytoid dendritic cells
    • Herbeuval JP, Hardy AW, Boasso A, Anderson SA, Dolan MJ, et al. (2005) Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 102: 13974-13979.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13974-13979
    • Herbeuval, J.P.1    Hardy, A.W.2    Boasso, A.3    Anderson, S.A.4    Dolan, M.J.5
  • 12
    • 0034329318 scopus 로고    scopus 로고
    • Mechanisms of HIV-associated lymphocyte apoptosis
    • Badley AD, Pilon AA, Landay A, Lynch DH (2000) Mechanisms of HIV-associated lymphocyte apoptosis. Blood 96: 2951-2964.
    • (2000) Blood , vol.96 , pp. 2951-2964
    • Badley, A.D.1    Pilon, A.A.2    Landay, A.3    Lynch, D.H.4
  • 13
    • 0030987288 scopus 로고    scopus 로고
    • CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro
    • Wu L, Paxton WA, Kassam N, Ruffing N, Rottman JB, et al. (1997) CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med 185: 1681-1691.
    • (1997) J Exp Med , vol.185 , pp. 1681-1691
    • Wu, L.1    Paxton, W.A.2    Kassam, N.3    Ruffing, N.4    Rottman, J.B.5
  • 14
    • 0030055293 scopus 로고    scopus 로고
    • Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway
    • Shattock RJ, Rizzardi GP, Hayes P, Griffin GE (1996) Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway. J Infect Dis 174: 54-62.
    • (1996) J Infect Dis , vol.174 , pp. 54-62
    • Shattock, R.J.1    Rizzardi, G.P.2    Hayes, P.3    Griffin, G.E.4
  • 16
    • 33646689587 scopus 로고    scopus 로고
    • Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection
    • Schacker TW, Brenchley JM, Beilman GJ, Reilly C, Pambuccian SE, et al. (2006) Lymphatic tissue fibrosis is associated with reduced numbers of naive CD4+ T cells in human immunodeficiency virus type 1 infection. Clin Vaccine Immunol 13: 556-560.
    • (2006) Clin Vaccine Immunol , vol.13 , pp. 556-560
    • Schacker, T.W.1    Brenchley, J.M.2    Beilman, G.J.3    Reilly, C.4    Pambuccian, S.E.5
  • 17
    • 27944487152 scopus 로고    scopus 로고
    • Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count
    • Schacker TW, Reilly C, Beilman GJ, Taylor J, Skarda D, et al. (2005) Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. Aids 19: 2169-2171.
    • (2005) Aids , vol.19 , pp. 2169-2171
    • Schacker, T.W.1    Reilly, C.2    Beilman, G.J.3    Taylor, J.4    Skarda, D.5
  • 18
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    • Kuller LH, Tracy R, Belloso W, De Wit S, Drummond F, et al. (2008) Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 5: e203.
    • (2008) PLoS Med , vol.e203 , pp. 5
    • Kuller, L.H.1    Tracy, R.2    Belloso, W.3    de Wit, S.4    Drummond, F.5
  • 21
    • 0035870543 scopus 로고    scopus 로고
    • A pilot study of the use of mycophenolate mofetil as a component of therapy for multidrug-resistant HIV-1 infection
    • Coull JJ, Turner D, Melby T, Betts MR, Lanier R, et al. (2001) A pilot study of the use of mycophenolate mofetil as a component of therapy for multidrug-resistant HIV-1 infection. J Acquir Immune Defic Syndr 26: 423-434.
    • (2001) J Acquir Immune Defic Syndr , vol.26 , pp. 423-434
    • Coull, J.J.1    Turner, D.2    Melby, T.3    Betts, M.R.4    Lanier, R.5
  • 22
    • 0036738830 scopus 로고    scopus 로고
    • The addition of mycophenolate mofetil to antiretroviral therapy including abacavir is associated with depletion of intracellular deoxyguanosine triphosphate and a decrease in plasma HIV-1 RNA
    • Margolis DM, Kewn S, Coull JJ, Ylisastigui L, Turner D, et al. (2002) The addition of mycophenolate mofetil to antiretroviral therapy including abacavir is associated with depletion of intracellular deoxyguanosine triphosphate and a decrease in plasma HIV-1 RNA. J Acquir Immune Defic Syndr 31: 45-49.
    • (2002) J Acquir Immune Defic Syndr , vol.31 , pp. 45-49
    • Margolis, D.M.1    Kewn, S.2    Coull, J.J.3    Ylisastigui, L.4    Turner, D.5
  • 23
    • 33845429615 scopus 로고    scopus 로고
    • Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: Results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138
    • Lederman MM, Smeaton L, Smith KY, Rodriguez B, Pu M, et al. (2006) Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138. J Infect Dis 194: 1677-1685.
    • (2006) J Infect Dis , vol.194 , pp. 1677-1685
    • Lederman, M.M.1    Smeaton, L.2    Smith, K.Y.3    Rodriguez, B.4    Pu, M.5
  • 24
    • 0031865023 scopus 로고    scopus 로고
    • Mechanism of action of leflunomide in rheumatoid arthritis
    • Fox RI (1998) Mechanism of action of leflunomide in rheumatoid arthritis. J Rheumatol Suppl 53: 20-26.
    • (1998) J Rheumatol Suppl , vol.53 , pp. 20-26
    • Fox, R.I.1
  • 25
    • 0029591467 scopus 로고
    • The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
    • Cherwinski HM, Cohn RG, Cheung P, Webster DJ, Xu YZ, et al. (1995) The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 275: 1043-1049.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1043-1049
    • Cherwinski, H.M.1    Cohn, R.G.2    Cheung, P.3    Webster, D.J.4    Xu, Y.Z.5
  • 26
    • 0038326642 scopus 로고    scopus 로고
    • Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides
    • Quemeneur L, Gerland LM, Flacher M, Ffrench M, Revillard JP, et al. (2003) Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides. J Immunol 170: 4986-4995.
    • (2003) J Immunol , vol.170 , pp. 4986-4995
    • Quemeneur, L.1    Gerland, L.M.2    Flacher, M.3    Ffrench, M.4    Revillard, J.P.5
  • 27
    • 29544450244 scopus 로고    scopus 로고
    • A prospective evaluation of leflunomide therapy for cytomegalovirus disease in renal transplant recipients
    • John GT, Manivannan J, Chandy S, Peter S, Fleming DH, et al. (2005) A prospective evaluation of leflunomide therapy for cytomegalovirus disease in renal transplant recipients. Transplant Proc 37: 4303-4305.
    • (2005) Transplant Proc , vol.37 , pp. 4303-4305
    • John, G.T.1    Manivannan, J.2    Chandy, S.3    Peter, S.4    Fleming, D.H.5
  • 28
    • 33645067944 scopus 로고    scopus 로고
    • Treatment of renal allograft polyoma BK virus infection with leflunomide
    • Josephson MA, Gillen D, Javaid B, Kadambi P, Meehan S, et al. (2006) Treatment of renal allograft polyoma BK virus infection with leflunomide. Transplantation 81: 704-710.
    • (2006) Transplantation , vol.81 , pp. 704-710
    • Josephson, M.A.1    Gillen, D.2    Javaid, B.3    Kadambi, P.4    Meehan, S.5
  • 29
    • 0035477184 scopus 로고    scopus 로고
    • Inhibition of HIV replication by A77 1726, the active metabolite of leflunomide, in combination with pyrimidine nucleoside reverse transcriptase inhibitors
    • Hossain MM, Margolis DM (2001) Inhibition of HIV replication by A77 1726, the active metabolite of leflunomide, in combination with pyrimidine nucleoside reverse transcriptase inhibitors. J Acquir Immune Defic Syndr 28: 199-201.
    • (2001) J Acquir Immune Defic Syndr , vol.28 , pp. 199-201
    • Hossain, M.M.1    Margolis, D.M.2
  • 30
    • 0042128295 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of leflunomide: A comparison with mycophenolic acid and hydroxyurea
    • Schlapfer E, Fischer M, Ott P, Speck RF (2003) Anti-HIV-1 activity of leflunomide: a comparison with mycophenolic acid and hydroxyurea. Aids 17: 1613-1620.
    • (2003) Aids , vol.17 , pp. 1613-1620
    • Schlapfer, E.1    Fischer, M.2    Ott, P.3    Speck, R.F.4
  • 31
    • 0035964685 scopus 로고    scopus 로고
    • CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV infected patients
    • Sereti I, Herpin B, Metcalf JA, Stevens R, Baseler MW, et al. (2001) CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV infected patients. Aids 15: 1765-1775.
    • (2001) Aids , vol.15 , pp. 1765-1775
    • Sereti, I.1    Herpin, B.2    Metcalf, J.A.3    Stevens, R.4    Baseler, M.W.5
  • 32
    • 12944331410 scopus 로고    scopus 로고
    • Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients
    • Lempicki RA, Kovacs JA, Baseler MW, Adelsberger JW, Dewar RL, et al. (2000) Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients. Proc Natl Acad Sci U S A 97: 13778-13783.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13778-13783
    • Lempicki, R.A.1    Kovacs, J.A.2    Baseler, M.W.3    Adelsberger, J.W.4    Dewar, R.L.5
  • 33
    • 0038580791 scopus 로고    scopus 로고
    • A real-time TaqMan PCR for routine quantitation of cytomegalovirus DNA in crude leukocyte lysates from stem cell transplant patients
    • Yun Z, Lewensohn-Fuchs I, Ljungman P, Ringholm L, Jonsson J, et al. (2003) A real-time TaqMan PCR for routine quantitation of cytomegalovirus DNA in crude leukocyte lysates from stem cell transplant patients. J Virol Methods 110: 73-79.
    • (2003) J Virol Methods , vol.110 , pp. 73-79
    • Yun, Z.1    Lewensohn-Fuchs, I.2    Ljungman, P.3    Ringholm, L.4    Jonsson, J.5
  • 34
    • 67650711146 scopus 로고    scopus 로고
    • Lessons learned from the natural hosts of HIV-related viruses
    • Paiardini M, Pandrea I, Apetrei C, Silvestri G (2009) Lessons learned from the natural hosts of HIV-related viruses. Annu Rev Med 60: 485-495.
    • (2009) Annu Rev Med , vol.60 , pp. 485-495
    • Paiardini, M.1    Pandrea, I.2    Apetrei, C.3    Silvestri, G.4
  • 35
    • 24044446145 scopus 로고    scopus 로고
    • Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis
    • Chan V, Charles BG, Tett SE (2005) Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis. Br J Clin Pharmacol 60: 257-264.
    • (2005) Br J Clin Pharmacol , vol.60 , pp. 257-264
    • Chan, V.1    Charles, B.G.2    Tett, S.E.3
  • 36
    • 16344379725 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: Serum concentrations predict response to treatment in patients with rheumatoid arthritis
    • van Roon EN, Jansen TL, van de Laar MA, Janssen M, Yska JP, et al. (2005) Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis 64: 569-574.
    • (2005) Ann Rheum Dis , vol.64 , pp. 569-574
    • van Roon, E.N.1    Jansen, T.L.2    van de Laar, M.A.3    Janssen, M.4    Yska, J.P.5


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